Association of homoarginine with arginine and disease severity in COVID-19 patients
Abstract This study explored the relationship between the concentrations of homoarginine and arginine and between homoarginine concentration and laboratory parameters in coronavirus disease 2019 (COVID-19) patients with different severity to demonstrate the role of homoarginine in the progress of CO...
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| Format: | Article |
| Language: | English |
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Springer
2025-05-01
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| Series: | Amino Acids |
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| Online Access: | https://doi.org/10.1007/s00726-025-03453-6 |
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| author | Zhiling Zhao Ting-Ting Wei Wan-Xue Zhang Shan-Shan Zhang Rui Wu Fei Li Han Yang Qiang Zhang Jingjing Xi Yiguo Zhou Tiehua Wang Juan Du Qing-Bin Lu Qinggang Ge |
| author_facet | Zhiling Zhao Ting-Ting Wei Wan-Xue Zhang Shan-Shan Zhang Rui Wu Fei Li Han Yang Qiang Zhang Jingjing Xi Yiguo Zhou Tiehua Wang Juan Du Qing-Bin Lu Qinggang Ge |
| author_sort | Zhiling Zhao |
| collection | DOAJ |
| description | Abstract This study explored the relationship between the concentrations of homoarginine and arginine and between homoarginine concentration and laboratory parameters in coronavirus disease 2019 (COVID-19) patients with different severity to demonstrate the role of homoarginine in the progress of COVID-19. The laboratory-confirmed COVID-19 patients were included from Peking University Third Hospital during December 2022 to January 2023. Serum, urine, and stool samples were collected from the patients and detected by liquid chromatography-mass spectrometry. Totally 46 patients were recruited, including 18 in the mild group, 19 in the severe group, and 9 fatal. The concentration of homoarginine was positively correlated with the concentration of arginine in serum (r = 0.50), urine (r = 0.55), and stool samples (r = 0.39), respectively (all P < 0.001). The serum concentration and urine concentration of homoarginine were lower in severe patients than in mild patients (both P < 0.05). 13 indicators reflecting immunity and coagulation, including but not limited to T cell, white blood cell, natural killer cell, interleukin 6 (IL-6), and IL-8, had statistically significant correlations with both disease severity and the homoarginine concentration. Patients with hypertension were significantly associated with the decreased serum homoarginine (odds ratio 10.905, 95% confidence interval 1.454 − 137.144). Our results suggest that the homoarginine plays a role in the progress of COVID-19, which may be achieved by influencing arginine metabolism. |
| format | Article |
| id | doaj-art-710ad1a00b2c4489a2f4e3cdc4e11af0 |
| institution | OA Journals |
| issn | 1438-2199 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Amino Acids |
| spelling | doaj-art-710ad1a00b2c4489a2f4e3cdc4e11af02025-08-20T02:15:28ZengSpringerAmino Acids1438-21992025-05-0157111210.1007/s00726-025-03453-6Association of homoarginine with arginine and disease severity in COVID-19 patientsZhiling Zhao0Ting-Ting Wei1Wan-Xue Zhang2Shan-Shan Zhang3Rui Wu4Fei Li5Han Yang6Qiang Zhang7Jingjing Xi8Yiguo Zhou9Tiehua Wang10Juan Du11Qing-Bin Lu12Qinggang Ge13Department of Intensive Care Medicine, Peking University Third HospitalDepartment of Laboratorial Science and Technology and Vaccine Research Center, School of Public Health, Peking UniversityCenter for Infectious Disease and Policy Research and Global Health and Infectious Diseases Group, Peking UniversityDepartment of Laboratorial Science and Technology and Vaccine Research Center, School of Public Health, Peking UniversityPulmonary and Critical Care Medicine, Peking University Third HospitalDepartment of General Surgery, Peking University Third HospitalCenter for Infectious Disease and Policy Research and Global Health and Infectious Diseases Group, Peking UniversityDepartment of Intensive Care Medicine, Peking University Third HospitalDepartment of Intensive Care Medicine, Peking University Third HospitalCenter for Infectious Disease and Policy Research and Global Health and Infectious Diseases Group, Peking UniversityDepartment of Intensive Care Medicine, Peking University Third HospitalDepartment of Laboratorial Science and Technology and Vaccine Research Center, School of Public Health, Peking UniversityDepartment of Laboratorial Science and Technology and Vaccine Research Center, School of Public Health, Peking UniversityDepartment of Intensive Care Medicine, Peking University Third HospitalAbstract This study explored the relationship between the concentrations of homoarginine and arginine and between homoarginine concentration and laboratory parameters in coronavirus disease 2019 (COVID-19) patients with different severity to demonstrate the role of homoarginine in the progress of COVID-19. The laboratory-confirmed COVID-19 patients were included from Peking University Third Hospital during December 2022 to January 2023. Serum, urine, and stool samples were collected from the patients and detected by liquid chromatography-mass spectrometry. Totally 46 patients were recruited, including 18 in the mild group, 19 in the severe group, and 9 fatal. The concentration of homoarginine was positively correlated with the concentration of arginine in serum (r = 0.50), urine (r = 0.55), and stool samples (r = 0.39), respectively (all P < 0.001). The serum concentration and urine concentration of homoarginine were lower in severe patients than in mild patients (both P < 0.05). 13 indicators reflecting immunity and coagulation, including but not limited to T cell, white blood cell, natural killer cell, interleukin 6 (IL-6), and IL-8, had statistically significant correlations with both disease severity and the homoarginine concentration. Patients with hypertension were significantly associated with the decreased serum homoarginine (odds ratio 10.905, 95% confidence interval 1.454 − 137.144). Our results suggest that the homoarginine plays a role in the progress of COVID-19, which may be achieved by influencing arginine metabolism.https://doi.org/10.1007/s00726-025-03453-6HomoarginineArginineCytokineCOVID-19Disease severity |
| spellingShingle | Zhiling Zhao Ting-Ting Wei Wan-Xue Zhang Shan-Shan Zhang Rui Wu Fei Li Han Yang Qiang Zhang Jingjing Xi Yiguo Zhou Tiehua Wang Juan Du Qing-Bin Lu Qinggang Ge Association of homoarginine with arginine and disease severity in COVID-19 patients Amino Acids Homoarginine Arginine Cytokine COVID-19 Disease severity |
| title | Association of homoarginine with arginine and disease severity in COVID-19 patients |
| title_full | Association of homoarginine with arginine and disease severity in COVID-19 patients |
| title_fullStr | Association of homoarginine with arginine and disease severity in COVID-19 patients |
| title_full_unstemmed | Association of homoarginine with arginine and disease severity in COVID-19 patients |
| title_short | Association of homoarginine with arginine and disease severity in COVID-19 patients |
| title_sort | association of homoarginine with arginine and disease severity in covid 19 patients |
| topic | Homoarginine Arginine Cytokine COVID-19 Disease severity |
| url | https://doi.org/10.1007/s00726-025-03453-6 |
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