Anticardiolipin Autoantibodies as Useful Biomarkers for the Prediction of Mortality in Septic Patients
Background. The detection of antiphospholipid antibodies (aPL) is of interest because of their importance in the pathogenesis of arterial or venous thrombosis. They could be a “second hit” of an inflammatory event such as infection. The aim of our study was to assess the performance of antiphospholi...
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| Format: | Article |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/9775111 |
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| author | Amal Abouda Z. Hajjej A. Mansart W. Kaabechi D. Elhaj Mahmoud O. Lamine E. Ghazouani M. Ferjani I. Labbene |
| author_facet | Amal Abouda Z. Hajjej A. Mansart W. Kaabechi D. Elhaj Mahmoud O. Lamine E. Ghazouani M. Ferjani I. Labbene |
| author_sort | Amal Abouda |
| collection | DOAJ |
| description | Background. The detection of antiphospholipid antibodies (aPL) is of interest because of their importance in the pathogenesis of arterial or venous thrombosis. They could be a “second hit” of an inflammatory event such as infection. The aim of our study was to assess the performance of antiphospholipid antibody biomarker to predict in-hospital mortality in intensive care unit (ICU) septic patients. Methods. We conducted a prospective single-center observational study including consecutive critically ill septic adults admitted to the intensive care unit. Clinical and laboratory data including enzyme-linked immunosorbent assay for antiphospholipid antibodies (anticardiolipin (aCL), antiphosphatidylserine (aPS)) were obtained. Blood samples were collected on days 1, 3, 5, 8, and 10 of hospitalization. The primary study endpoint was ICU mortality defined as death before ICU discharge. Secondary end points included correlation between SOFA score and biological parameters. Results. A total of 53 patients were enrolled. 18.8% of patients were aPL positive. In-hospital mortality rate was 60%. Multivariate analysis showed that age and aCL at days 3 and 5 along with SOFA at day 3 were independent outcome predictors. A significant positive correlation existed between SOFA at days 3, 5, and 8 and antiphospholipid antibody concentrations. Conclusions. Our data showed that antiphospholipid was useful biomarkers for the prediction of mortality in critically ill septic patients. We found a positive correlation between SOFA score and antiphospholipid antibodies. |
| format | Article |
| id | doaj-art-70faa5b3c1a144f19b13ac2a8e8de67d |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-70faa5b3c1a144f19b13ac2a8e8de67d2025-02-03T01:06:38ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/9775111Anticardiolipin Autoantibodies as Useful Biomarkers for the Prediction of Mortality in Septic PatientsAmal Abouda0Z. Hajjej1A. Mansart2W. Kaabechi3D. Elhaj Mahmoud4O. Lamine5E. Ghazouani6M. Ferjani7I. Labbene8Intensive Care UnitIntensive Care UnitUniversity of Paris-SaclayMedicine Faculty of TunisImmuno-Rheumatology Research LaboratoryDepartment of BiochemistryLaboratory of ImmunologyIntensive Care UnitIntensive Care UnitBackground. The detection of antiphospholipid antibodies (aPL) is of interest because of their importance in the pathogenesis of arterial or venous thrombosis. They could be a “second hit” of an inflammatory event such as infection. The aim of our study was to assess the performance of antiphospholipid antibody biomarker to predict in-hospital mortality in intensive care unit (ICU) septic patients. Methods. We conducted a prospective single-center observational study including consecutive critically ill septic adults admitted to the intensive care unit. Clinical and laboratory data including enzyme-linked immunosorbent assay for antiphospholipid antibodies (anticardiolipin (aCL), antiphosphatidylserine (aPS)) were obtained. Blood samples were collected on days 1, 3, 5, 8, and 10 of hospitalization. The primary study endpoint was ICU mortality defined as death before ICU discharge. Secondary end points included correlation between SOFA score and biological parameters. Results. A total of 53 patients were enrolled. 18.8% of patients were aPL positive. In-hospital mortality rate was 60%. Multivariate analysis showed that age and aCL at days 3 and 5 along with SOFA at day 3 were independent outcome predictors. A significant positive correlation existed between SOFA at days 3, 5, and 8 and antiphospholipid antibody concentrations. Conclusions. Our data showed that antiphospholipid was useful biomarkers for the prediction of mortality in critically ill septic patients. We found a positive correlation between SOFA score and antiphospholipid antibodies.http://dx.doi.org/10.1155/2022/9775111 |
| spellingShingle | Amal Abouda Z. Hajjej A. Mansart W. Kaabechi D. Elhaj Mahmoud O. Lamine E. Ghazouani M. Ferjani I. Labbene Anticardiolipin Autoantibodies as Useful Biomarkers for the Prediction of Mortality in Septic Patients Journal of Immunology Research |
| title | Anticardiolipin Autoantibodies as Useful Biomarkers for the Prediction of Mortality in Septic Patients |
| title_full | Anticardiolipin Autoantibodies as Useful Biomarkers for the Prediction of Mortality in Septic Patients |
| title_fullStr | Anticardiolipin Autoantibodies as Useful Biomarkers for the Prediction of Mortality in Septic Patients |
| title_full_unstemmed | Anticardiolipin Autoantibodies as Useful Biomarkers for the Prediction of Mortality in Septic Patients |
| title_short | Anticardiolipin Autoantibodies as Useful Biomarkers for the Prediction of Mortality in Septic Patients |
| title_sort | anticardiolipin autoantibodies as useful biomarkers for the prediction of mortality in septic patients |
| url | http://dx.doi.org/10.1155/2022/9775111 |
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