Association between dietary inflammatory index and osteoporosis in the US population: evidence from NHANES 2003–2010
ObjectiveThis study aimed to explore the association between the Dietary Inflammatory Index (DII) and the prevalence of osteoporosis in the U.S. population, using data from the National Health and Nutrition Examination Survey (NHANES) 2003–2010.MethodsData from 7,290 participants in the NHANES 2003–...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1508127/full |
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| author | Zhiwen Liu Huanling Jian Zijing Peng Sicheng Xiong Zhihai Zhang |
| author_facet | Zhiwen Liu Huanling Jian Zijing Peng Sicheng Xiong Zhihai Zhang |
| author_sort | Zhiwen Liu |
| collection | DOAJ |
| description | ObjectiveThis study aimed to explore the association between the Dietary Inflammatory Index (DII) and the prevalence of osteoporosis in the U.S. population, using data from the National Health and Nutrition Examination Survey (NHANES) 2003–2010.MethodsData from 7,290 participants in the NHANES 2003–2010 survey were analyzed. The relationship between the DII and osteoporosis was evaluated using weighted multivariate logistic regression, and potential non-linear associations were explored through restricted cubic spline (RCS) regression. Subgroup analyses were conducted with stratified models, and the findings were depicted in a forest plot. To pinpoint key dietary factors associated with osteoporosis, we applied least absolute shrinkage and selection operator (LASSO) regression. These factors were integrated into a nomogram for risk prediction, with the model’s discriminative ability assessed via the receiver operating characteristic (ROC) curve.ResultsOsteoporosis patients had higher DII scores than those without the condition (1.61 vs. 1.18, p < 0.001). After adjusting for covariates, participants in the highest DII quartile had an 88% greater risk of osteoporosis (OR: 1.88, 95% CI: 1.41–2.52, P for trend <0.001). Restricted cubic spline analysis confirmed a linear relationship between DII and osteoporosis risk. Subgroup analyses showed similar patterns across different groups, as illustrated by the forest plot. LASSO regression identified key dietary factors, which were used to build a nomogram with an AUC of 83.6%, indicating strong predictive accuracy.ConclusionA higher DII is strongly linked to increased osteoporosis risk, underscoring the importance of reducing dietary inflammation to help prevent osteoporosis. |
| format | Article |
| id | doaj-art-70ef2faf1769449aa157f21fefce4897 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-70ef2faf1769449aa157f21fefce48972025-01-29T15:21:58ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.15081271508127Association between dietary inflammatory index and osteoporosis in the US population: evidence from NHANES 2003–2010Zhiwen Liu0Huanling Jian1Zijing Peng2Sicheng Xiong3Zhihai Zhang4The Third Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Third Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Third Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaObjectiveThis study aimed to explore the association between the Dietary Inflammatory Index (DII) and the prevalence of osteoporosis in the U.S. population, using data from the National Health and Nutrition Examination Survey (NHANES) 2003–2010.MethodsData from 7,290 participants in the NHANES 2003–2010 survey were analyzed. The relationship between the DII and osteoporosis was evaluated using weighted multivariate logistic regression, and potential non-linear associations were explored through restricted cubic spline (RCS) regression. Subgroup analyses were conducted with stratified models, and the findings were depicted in a forest plot. To pinpoint key dietary factors associated with osteoporosis, we applied least absolute shrinkage and selection operator (LASSO) regression. These factors were integrated into a nomogram for risk prediction, with the model’s discriminative ability assessed via the receiver operating characteristic (ROC) curve.ResultsOsteoporosis patients had higher DII scores than those without the condition (1.61 vs. 1.18, p < 0.001). After adjusting for covariates, participants in the highest DII quartile had an 88% greater risk of osteoporosis (OR: 1.88, 95% CI: 1.41–2.52, P for trend <0.001). Restricted cubic spline analysis confirmed a linear relationship between DII and osteoporosis risk. Subgroup analyses showed similar patterns across different groups, as illustrated by the forest plot. LASSO regression identified key dietary factors, which were used to build a nomogram with an AUC of 83.6%, indicating strong predictive accuracy.ConclusionA higher DII is strongly linked to increased osteoporosis risk, underscoring the importance of reducing dietary inflammation to help prevent osteoporosis.https://www.frontiersin.org/articles/10.3389/fnut.2025.1508127/fullNHANESDIIosteoporosiscross-sectional studyLASSO |
| spellingShingle | Zhiwen Liu Huanling Jian Zijing Peng Sicheng Xiong Zhihai Zhang Association between dietary inflammatory index and osteoporosis in the US population: evidence from NHANES 2003–2010 Frontiers in Nutrition NHANES DII osteoporosis cross-sectional study LASSO |
| title | Association between dietary inflammatory index and osteoporosis in the US population: evidence from NHANES 2003–2010 |
| title_full | Association between dietary inflammatory index and osteoporosis in the US population: evidence from NHANES 2003–2010 |
| title_fullStr | Association between dietary inflammatory index and osteoporosis in the US population: evidence from NHANES 2003–2010 |
| title_full_unstemmed | Association between dietary inflammatory index and osteoporosis in the US population: evidence from NHANES 2003–2010 |
| title_short | Association between dietary inflammatory index and osteoporosis in the US population: evidence from NHANES 2003–2010 |
| title_sort | association between dietary inflammatory index and osteoporosis in the us population evidence from nhanes 2003 2010 |
| topic | NHANES DII osteoporosis cross-sectional study LASSO |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1508127/full |
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