Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma
miRNAs are small non-coding RNA molecules that play critical roles in the regulation of gene expression and have been closely associated with various diseases, including cancer. These molecules significantly influence the cell cycle of tumor cells and control programmed cell death (apoptosis). Curre...
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2025-01-01
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| author | Lin Wang Xinyu Liu Haoze Lv Han Zhang Rimei Lin Shan Xu Chaojing Zhang Shilei Lou Zhidong Qiu Cong Sun Ning Cui |
| author_facet | Lin Wang Xinyu Liu Haoze Lv Han Zhang Rimei Lin Shan Xu Chaojing Zhang Shilei Lou Zhidong Qiu Cong Sun Ning Cui |
| author_sort | Lin Wang |
| collection | DOAJ |
| description | miRNAs are small non-coding RNA molecules that play critical roles in the regulation of gene expression and have been closely associated with various diseases, including cancer. These molecules significantly influence the cell cycle of tumor cells and control programmed cell death (apoptosis). Currently, research on miRNAs has become a major focus in developing cancer therapies. Osteosarcoma, a malignant neoplasm predominantly occurring during adolescence and later in life, is characterized by a high propensity for metastasis. This review explores the role of miRNAs in the initiation and progression of cancer, highlighting their potential as predictive biomarkers for disease. It discusses the mechanisms by which natural products modulate miRNA activity to influence apoptosis, ferroptosis, and autophagy in osteosarcoma cells, aiming to identify new strategies for osteosarcoma treatment. Recent studies on how natural products regulate miRNAs to reduce tumor cell resistance to chemotherapy are also reviewed. Furthermore, the review elaborates on how natural products regulate m6A modifications to influence miRNA expression, thereby exerting antitumor effects. In this process, interactions between m6A modifications and miRNAs have been identified, with both jointly influencing tumorigenesis and cancer progression, offering a new perspective in osteosarcoma treatment. These approaches could help uncover novel regulatory mechanisms in osteosarcoma pathways and provide a theoretical foundation for developing new drugs and identifying novel therapeutic targets. |
| format | Article |
| id | doaj-art-70e8471f8dd6462a8d0781502af92857 |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-70e8471f8dd6462a8d0781502af928572025-01-24T13:23:29ZengMDPI AGBiology2079-77372025-01-011416110.3390/biology14010061Research Progress on Natural Products That Regulate miRNAs in the Treatment of OsteosarcomaLin Wang0Xinyu Liu1Haoze Lv2Han Zhang3Rimei Lin4Shan Xu5Chaojing Zhang6Shilei Lou7Zhidong Qiu8Cong Sun9Ning Cui10School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaCollege of Clinical Medicine, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaCollege of Clinical Medicine, Changchun University of Chinese Medicine, Changchun 130117, ChinaNortheast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, ChinamiRNAs are small non-coding RNA molecules that play critical roles in the regulation of gene expression and have been closely associated with various diseases, including cancer. These molecules significantly influence the cell cycle of tumor cells and control programmed cell death (apoptosis). Currently, research on miRNAs has become a major focus in developing cancer therapies. Osteosarcoma, a malignant neoplasm predominantly occurring during adolescence and later in life, is characterized by a high propensity for metastasis. This review explores the role of miRNAs in the initiation and progression of cancer, highlighting their potential as predictive biomarkers for disease. It discusses the mechanisms by which natural products modulate miRNA activity to influence apoptosis, ferroptosis, and autophagy in osteosarcoma cells, aiming to identify new strategies for osteosarcoma treatment. Recent studies on how natural products regulate miRNAs to reduce tumor cell resistance to chemotherapy are also reviewed. Furthermore, the review elaborates on how natural products regulate m6A modifications to influence miRNA expression, thereby exerting antitumor effects. In this process, interactions between m6A modifications and miRNAs have been identified, with both jointly influencing tumorigenesis and cancer progression, offering a new perspective in osteosarcoma treatment. These approaches could help uncover novel regulatory mechanisms in osteosarcoma pathways and provide a theoretical foundation for developing new drugs and identifying novel therapeutic targets.https://www.mdpi.com/2079-7737/14/1/61osteosarcomamiRNAnatural medicinesprogrammed cell deathm6A modification |
| spellingShingle | Lin Wang Xinyu Liu Haoze Lv Han Zhang Rimei Lin Shan Xu Chaojing Zhang Shilei Lou Zhidong Qiu Cong Sun Ning Cui Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma Biology osteosarcoma miRNA natural medicines programmed cell death m6A modification |
| title | Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma |
| title_full | Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma |
| title_fullStr | Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma |
| title_full_unstemmed | Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma |
| title_short | Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma |
| title_sort | research progress on natural products that regulate mirnas in the treatment of osteosarcoma |
| topic | osteosarcoma miRNA natural medicines programmed cell death m6A modification |
| url | https://www.mdpi.com/2079-7737/14/1/61 |
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