Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts
Although vascularized composite allografts (VCAs) have been performed clinically for a variety of indications, potential complications from long-term immunosuppression and graft-versus-host disease remain important barriers to widespread applications. Recently it has been demonstrated that VCAs inco...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/107901 |
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| _version_ | 1832548122912358400 |
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| author | Wei-Chao Huang Jeng-Yee Lin Christopher Glenn Wallace Fu-Chan Wei Shuen-Kuei Liao |
| author_facet | Wei-Chao Huang Jeng-Yee Lin Christopher Glenn Wallace Fu-Chan Wei Shuen-Kuei Liao |
| author_sort | Wei-Chao Huang |
| collection | DOAJ |
| description | Although vascularized composite allografts (VCAs) have been performed clinically for a variety of indications, potential complications from long-term immunosuppression and graft-versus-host disease remain important barriers to widespread applications. Recently it has been demonstrated that VCAs incorporating a vascularized long bone in a rat model provide concurrent vascularized bone marrow transplantation that, itself, functions to establish hematopoietic chimerism and donor-specific tolerance following non-myeloablative conditioning of recipients. Advances such as this, which aim to improve the safety profile of tolerance induction, will help usher in an era of wider clinical VCA application for nonlife-saving reconstructions. |
| format | Article |
| id | doaj-art-70e61f3482c54d49a315f57bd203d076 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-70e61f3482c54d49a315f57bd203d0762025-02-03T06:42:10ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/107901107901Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite AllograftsWei-Chao Huang0Jeng-Yee Lin1Christopher Glenn Wallace2Fu-Chan Wei3Shuen-Kuei Liao4Division of Plastic and Reconstructive Surgery, Tzu Chi General Hospital, New Taipei 231, TaiwanGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDepartment of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanAlthough vascularized composite allografts (VCAs) have been performed clinically for a variety of indications, potential complications from long-term immunosuppression and graft-versus-host disease remain important barriers to widespread applications. Recently it has been demonstrated that VCAs incorporating a vascularized long bone in a rat model provide concurrent vascularized bone marrow transplantation that, itself, functions to establish hematopoietic chimerism and donor-specific tolerance following non-myeloablative conditioning of recipients. Advances such as this, which aim to improve the safety profile of tolerance induction, will help usher in an era of wider clinical VCA application for nonlife-saving reconstructions.http://dx.doi.org/10.1155/2012/107901 |
| spellingShingle | Wei-Chao Huang Jeng-Yee Lin Christopher Glenn Wallace Fu-Chan Wei Shuen-Kuei Liao Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts Clinical and Developmental Immunology |
| title | Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts |
| title_full | Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts |
| title_fullStr | Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts |
| title_full_unstemmed | Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts |
| title_short | Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts |
| title_sort | improving the safety of tolerance induction chimerism and cellular co treatment strategies applied to vascularized composite allografts |
| url | http://dx.doi.org/10.1155/2012/107901 |
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