Prevalence of non-vaccine high-risk HPV cervical infections in vaccinated women: a systematic review and meta-analysis
Abstract Background Human Papillomavirus (HPV) is the most common sexually transmitted lower genital tract infection worldwide and the main etiological factor of cervical cancer (CC). Since 2006, vaccines have been implemented to reduce CC-related morbidity and mortality. This systematic review and...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-025-10520-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832572007924891648 |
|---|---|
| author | Glauciane Resende do Nascimento Ana Carolina da Silva Santos Nayara Nascimento Toledo Silva Nathalia Sernizon Guilmarães Angélica Alves Lima Wendel Coura-Vital |
| author_facet | Glauciane Resende do Nascimento Ana Carolina da Silva Santos Nayara Nascimento Toledo Silva Nathalia Sernizon Guilmarães Angélica Alves Lima Wendel Coura-Vital |
| author_sort | Glauciane Resende do Nascimento |
| collection | DOAJ |
| description | Abstract Background Human Papillomavirus (HPV) is the most common sexually transmitted lower genital tract infection worldwide and the main etiological factor of cervical cancer (CC). Since 2006, vaccines have been implemented to reduce CC-related morbidity and mortality. This systematic review and meta-analysis aimed to evaluate the prevalence of cervical infections by non-vaccine high-risk HPV (HR-HPV) types in women vaccinated against types 16 and 18. Method This systematic review and meta-analysis used independent electronic databases – Lilacs, WHO, BDENF, State Department of Health SP, Health Information Locator, IRIS, Coleciona Sistema Único de Saúde, BINACIS, IBECS, CUMED and SciELO, on July 14, 2023. Observational studies that evaluated vaccinated and unvaccinated women against HR-HPV and the prevalence of cervical infection by types of HR-HPV were included. Intervention effects were expressed as prevalence ratios (PR). Forest plots were used to visualize vaccination effects. The study protocol was previously registered in PROSPERO, under code CRD42023440610. Results Of the 7,051 studies, 31 met the analysis criteria. A total of 59,035 women were eligible for this systematic review. The results showed a high prevalence of non-vaccine HR-HPV types, regardless of vaccination status. For HPV 31/33/45 (PR = 0.60 [0.40–0.91]), HPV31 (PR = 0.47 [0.31–0.72]), and HPV 45 (PR = 0.38 [0.22–0.69]), a positive random effect was found. Conclusion The prevalence of non-vaccine HR-HPV cervical infection was high in women, regardless of vaccination status. For HPV types 31 and 45 and 31/33/45, the prevalence was lower in vaccinated women, suggesting a cross-protective effect of vaccines for these viral types. |
| format | Article |
| id | doaj-art-70e0fa03ba134809b9707fcb4b19e3c1 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-70e0fa03ba134809b9707fcb4b19e3c12025-02-02T12:10:24ZengBMCBMC Infectious Diseases1471-23342025-01-0125111010.1186/s12879-025-10520-6Prevalence of non-vaccine high-risk HPV cervical infections in vaccinated women: a systematic review and meta-analysisGlauciane Resende do Nascimento0Ana Carolina da Silva Santos1Nayara Nascimento Toledo Silva2Nathalia Sernizon Guilmarães3Angélica Alves Lima4Wendel Coura-Vital5Programa de Pós-graduação em Ciências Farmacêuticas, Escola de Farmácia, Universidade Federal de Ouro PretoPrograma de Pós-graduação em Ciências Farmacêuticas, Escola de Farmácia, Universidade Federal de Ouro PretoDepartamento de Análises Clínicas, Escola de Farmácia, Universidade Federal de Ouro PretoDepartamento de Nutrição, Escola de Enfermagem, Universidade Federal de Minas GeraisPrograma de Pós-graduação em Ciências Farmacêuticas, Escola de Farmácia, Universidade Federal de Ouro PretoPrograma de Pós-graduação em Ciências Farmacêuticas, Escola de Farmácia, Universidade Federal de Ouro PretoAbstract Background Human Papillomavirus (HPV) is the most common sexually transmitted lower genital tract infection worldwide and the main etiological factor of cervical cancer (CC). Since 2006, vaccines have been implemented to reduce CC-related morbidity and mortality. This systematic review and meta-analysis aimed to evaluate the prevalence of cervical infections by non-vaccine high-risk HPV (HR-HPV) types in women vaccinated against types 16 and 18. Method This systematic review and meta-analysis used independent electronic databases – Lilacs, WHO, BDENF, State Department of Health SP, Health Information Locator, IRIS, Coleciona Sistema Único de Saúde, BINACIS, IBECS, CUMED and SciELO, on July 14, 2023. Observational studies that evaluated vaccinated and unvaccinated women against HR-HPV and the prevalence of cervical infection by types of HR-HPV were included. Intervention effects were expressed as prevalence ratios (PR). Forest plots were used to visualize vaccination effects. The study protocol was previously registered in PROSPERO, under code CRD42023440610. Results Of the 7,051 studies, 31 met the analysis criteria. A total of 59,035 women were eligible for this systematic review. The results showed a high prevalence of non-vaccine HR-HPV types, regardless of vaccination status. For HPV 31/33/45 (PR = 0.60 [0.40–0.91]), HPV31 (PR = 0.47 [0.31–0.72]), and HPV 45 (PR = 0.38 [0.22–0.69]), a positive random effect was found. Conclusion The prevalence of non-vaccine HR-HPV cervical infection was high in women, regardless of vaccination status. For HPV types 31 and 45 and 31/33/45, the prevalence was lower in vaccinated women, suggesting a cross-protective effect of vaccines for these viral types.https://doi.org/10.1186/s12879-025-10520-6Human papillomavirusVaccineHigh-risk HPVSystematic ReviewMeta-analysisPrevalence |
| spellingShingle | Glauciane Resende do Nascimento Ana Carolina da Silva Santos Nayara Nascimento Toledo Silva Nathalia Sernizon Guilmarães Angélica Alves Lima Wendel Coura-Vital Prevalence of non-vaccine high-risk HPV cervical infections in vaccinated women: a systematic review and meta-analysis BMC Infectious Diseases Human papillomavirus Vaccine High-risk HPV Systematic Review Meta-analysis Prevalence |
| title | Prevalence of non-vaccine high-risk HPV cervical infections in vaccinated women: a systematic review and meta-analysis |
| title_full | Prevalence of non-vaccine high-risk HPV cervical infections in vaccinated women: a systematic review and meta-analysis |
| title_fullStr | Prevalence of non-vaccine high-risk HPV cervical infections in vaccinated women: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of non-vaccine high-risk HPV cervical infections in vaccinated women: a systematic review and meta-analysis |
| title_short | Prevalence of non-vaccine high-risk HPV cervical infections in vaccinated women: a systematic review and meta-analysis |
| title_sort | prevalence of non vaccine high risk hpv cervical infections in vaccinated women a systematic review and meta analysis |
| topic | Human papillomavirus Vaccine High-risk HPV Systematic Review Meta-analysis Prevalence |
| url | https://doi.org/10.1186/s12879-025-10520-6 |
| work_keys_str_mv | AT glaucianeresendedonascimento prevalenceofnonvaccinehighriskhpvcervicalinfectionsinvaccinatedwomenasystematicreviewandmetaanalysis AT anacarolinadasilvasantos prevalenceofnonvaccinehighriskhpvcervicalinfectionsinvaccinatedwomenasystematicreviewandmetaanalysis AT nayaranascimentotoledosilva prevalenceofnonvaccinehighriskhpvcervicalinfectionsinvaccinatedwomenasystematicreviewandmetaanalysis AT nathaliasernizonguilmaraes prevalenceofnonvaccinehighriskhpvcervicalinfectionsinvaccinatedwomenasystematicreviewandmetaanalysis AT angelicaalveslima prevalenceofnonvaccinehighriskhpvcervicalinfectionsinvaccinatedwomenasystematicreviewandmetaanalysis AT wendelcouravital prevalenceofnonvaccinehighriskhpvcervicalinfectionsinvaccinatedwomenasystematicreviewandmetaanalysis |