Polygala tenuifolia Willd. Extract delays non-alcoholic fatty liver disease progression in rats via the COX2 and PERK-elF2α-ATF4 pathway

Polygala tenuifolia Willd. Extract delays non-alcoholic fatty liver disease progression in rats via the COX2 and PERK-elF2α-ATF4 pathway

BackgroundNon-alcoholic fatty liver disease (NAFLD), a chronic liver disease posing a severe threat to human health, currently lacks specific therapeutic drugs. Our previous studies have demonstrated that Polygala tenuifolia Willd. Extract (EPT) can significantly suppress the PGE2 inflammatory pathw...

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Bibliographic Details
Main Authors: Zhiliang Sun, Zhongshi Zhou, Kezheng Liao, Yanju Liu, Yanyun Liu, Chaoyang Wang, Zhihua Zhang, Li Wen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
Polygala tenuifolia
NAFLD
PERK-ELF2α-ATF4
inflammation
Chinese medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1595752/full
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