Fluoride exposure, personal susceptibility and osteoarticular degeneration: Evidence from farmers in the Yellow River Basin of Henan Province
Osteoarticular degeneration (OAD) is an important issue. Excessive fluoride can damage osteoarticular health. Besides, personal susceptibility (including genetic factors, physiological characteristics, and lifestyle) also contributes to osteoarticular development significantly. However, little evide...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324015112 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591034877476864 |
|---|---|
| author | Zichen Feng Long Sun Shu Niu Bin Liu Ruijie Ba Guoqing Wang Qing Sun Chunxiang Li Yan Wang Fangfang Yu Guoyu Zhou Yue Ba |
| author_facet | Zichen Feng Long Sun Shu Niu Bin Liu Ruijie Ba Guoqing Wang Qing Sun Chunxiang Li Yan Wang Fangfang Yu Guoyu Zhou Yue Ba |
| author_sort | Zichen Feng |
| collection | DOAJ |
| description | Osteoarticular degeneration (OAD) is an important issue. Excessive fluoride can damage osteoarticular health. Besides, personal susceptibility (including genetic factors, physiological characteristics, and lifestyle) also contributes to osteoarticular development significantly. However, little evidence focused on the comprehensive modification of fluoride exposure and personal susceptibility on osteoarticular health. Thus, this study explored the relationships among fluoride exposure, genetic factors, physiological characteristics, lifestyle, and OAD risk, as well as the potential interactions among contributors in 593 adults from a cross-sectional study conducted in 2017. We observed that the OAD (n = 175) risk was increased with increasing urinary fluoride (UF) levels (OR=1.484; 95 %CI: 1.043, 2.111), age (OR=1.065; 95 %CI: 1.033, 1.098), and hip circumference (OR=1.069; 95 %CI: 1.014, 1.127), as well as a poor night sleep quality (OR=1.818; 95 %CI: 1.072, 3.084). More fruit consumption (>350 g/d) was beneficial to OAD prevention (OR=0.102; 95 %CI: 0.012, 0.850). Genetic susceptibility analysis showed that the CG genotype of calcitonin related polypeptide alpha (CALCA) rs1553005 loci was related to higher OAD risk (OR=1.959; 95 %CI: 1.003, 3.825), whereas higher methylation status of GNAS complex locus (GNAS) (OR=0.617; 95 %CI: 0.410, 0.929) and TC genotype of rs7121 loci (OR=0.569; 95 %CI: 0.371, 0.871) showed protective effect on OAD. Additionally, OAD risk was related to the interaction of fluoride-rs1553005 polymorphism-rs7121 polymorphism-GNAS methylation, fluoride-age-fruits, age-fruits, and rs1553005 polymorphism-GNAS methylation-rs7121 polymorphism-age-hip circumference-fruits-UF. Findings suggested that the OAD susceptibility might be modified by the interactions between fluoride and personal susceptibility. |
| format | Article |
| id | doaj-art-70a57bf9da274f87a94d0278bc6e350e |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-70a57bf9da274f87a94d0278bc6e350e2025-01-23T05:25:32ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117435Fluoride exposure, personal susceptibility and osteoarticular degeneration: Evidence from farmers in the Yellow River Basin of Henan ProvinceZichen Feng0Long Sun1Shu Niu2Bin Liu3Ruijie Ba4Guoqing Wang5Qing Sun6Chunxiang Li7Yan Wang8Fangfang Yu9Guoyu Zhou10Yue Ba11Department of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, ChinaDepartment of Endemic Disease, Kaifeng Center for Disease Control and Prevention, Kaifeng, Henan 475000, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, China; Corresponding author.Osteoarticular degeneration (OAD) is an important issue. Excessive fluoride can damage osteoarticular health. Besides, personal susceptibility (including genetic factors, physiological characteristics, and lifestyle) also contributes to osteoarticular development significantly. However, little evidence focused on the comprehensive modification of fluoride exposure and personal susceptibility on osteoarticular health. Thus, this study explored the relationships among fluoride exposure, genetic factors, physiological characteristics, lifestyle, and OAD risk, as well as the potential interactions among contributors in 593 adults from a cross-sectional study conducted in 2017. We observed that the OAD (n = 175) risk was increased with increasing urinary fluoride (UF) levels (OR=1.484; 95 %CI: 1.043, 2.111), age (OR=1.065; 95 %CI: 1.033, 1.098), and hip circumference (OR=1.069; 95 %CI: 1.014, 1.127), as well as a poor night sleep quality (OR=1.818; 95 %CI: 1.072, 3.084). More fruit consumption (>350 g/d) was beneficial to OAD prevention (OR=0.102; 95 %CI: 0.012, 0.850). Genetic susceptibility analysis showed that the CG genotype of calcitonin related polypeptide alpha (CALCA) rs1553005 loci was related to higher OAD risk (OR=1.959; 95 %CI: 1.003, 3.825), whereas higher methylation status of GNAS complex locus (GNAS) (OR=0.617; 95 %CI: 0.410, 0.929) and TC genotype of rs7121 loci (OR=0.569; 95 %CI: 0.371, 0.871) showed protective effect on OAD. Additionally, OAD risk was related to the interaction of fluoride-rs1553005 polymorphism-rs7121 polymorphism-GNAS methylation, fluoride-age-fruits, age-fruits, and rs1553005 polymorphism-GNAS methylation-rs7121 polymorphism-age-hip circumference-fruits-UF. Findings suggested that the OAD susceptibility might be modified by the interactions between fluoride and personal susceptibility.http://www.sciencedirect.com/science/article/pii/S0147651324015112FluoridePersonal susceptibilityCALCAGNASOsteoarticular degeneration |
| spellingShingle | Zichen Feng Long Sun Shu Niu Bin Liu Ruijie Ba Guoqing Wang Qing Sun Chunxiang Li Yan Wang Fangfang Yu Guoyu Zhou Yue Ba Fluoride exposure, personal susceptibility and osteoarticular degeneration: Evidence from farmers in the Yellow River Basin of Henan Province Ecotoxicology and Environmental Safety Fluoride Personal susceptibility CALCA GNAS Osteoarticular degeneration |
| title | Fluoride exposure, personal susceptibility and osteoarticular degeneration: Evidence from farmers in the Yellow River Basin of Henan Province |
| title_full | Fluoride exposure, personal susceptibility and osteoarticular degeneration: Evidence from farmers in the Yellow River Basin of Henan Province |
| title_fullStr | Fluoride exposure, personal susceptibility and osteoarticular degeneration: Evidence from farmers in the Yellow River Basin of Henan Province |
| title_full_unstemmed | Fluoride exposure, personal susceptibility and osteoarticular degeneration: Evidence from farmers in the Yellow River Basin of Henan Province |
| title_short | Fluoride exposure, personal susceptibility and osteoarticular degeneration: Evidence from farmers in the Yellow River Basin of Henan Province |
| title_sort | fluoride exposure personal susceptibility and osteoarticular degeneration evidence from farmers in the yellow river basin of henan province |
| topic | Fluoride Personal susceptibility CALCA GNAS Osteoarticular degeneration |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324015112 |
| work_keys_str_mv | AT zichenfeng fluorideexposurepersonalsusceptibilityandosteoarticulardegenerationevidencefromfarmersintheyellowriverbasinofhenanprovince AT longsun fluorideexposurepersonalsusceptibilityandosteoarticulardegenerationevidencefromfarmersintheyellowriverbasinofhenanprovince AT shuniu fluorideexposurepersonalsusceptibilityandosteoarticulardegenerationevidencefromfarmersintheyellowriverbasinofhenanprovince AT binliu fluorideexposurepersonalsusceptibilityandosteoarticulardegenerationevidencefromfarmersintheyellowriverbasinofhenanprovince AT ruijieba fluorideexposurepersonalsusceptibilityandosteoarticulardegenerationevidencefromfarmersintheyellowriverbasinofhenanprovince AT guoqingwang fluorideexposurepersonalsusceptibilityandosteoarticulardegenerationevidencefromfarmersintheyellowriverbasinofhenanprovince AT qingsun fluorideexposurepersonalsusceptibilityandosteoarticulardegenerationevidencefromfarmersintheyellowriverbasinofhenanprovince AT chunxiangli fluorideexposurepersonalsusceptibilityandosteoarticulardegenerationevidencefromfarmersintheyellowriverbasinofhenanprovince AT yanwang fluorideexposurepersonalsusceptibilityandosteoarticulardegenerationevidencefromfarmersintheyellowriverbasinofhenanprovince AT fangfangyu fluorideexposurepersonalsusceptibilityandosteoarticulardegenerationevidencefromfarmersintheyellowriverbasinofhenanprovince AT guoyuzhou fluorideexposurepersonalsusceptibilityandosteoarticulardegenerationevidencefromfarmersintheyellowriverbasinofhenanprovince AT yueba fluorideexposurepersonalsusceptibilityandosteoarticulardegenerationevidencefromfarmersintheyellowriverbasinofhenanprovince |