A Pediatric Case of Relapsing-Remitting Multiple Sclerosis Onset following Varicella Zoster Ophthalmicus with Optic Neuritis
Some epidemiological studies have implied a pathogenetic association between varicella zoster virus (VZV) and multiple sclerosis (MS); this, however, remains controversial. The present report describes a case involving an immunocompetent 10-year-old girl who developed relapsing-remitting MS followin...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2018/6931206 |
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| author | Naoko Shiba Yuji Inaba Mitsuo Motobayashi Makoto Nishioka Yoichiro Kawasaki Shunsuke Noda Hiroki Matsuura Norimoto Kobayashi Takafumi Matsuoka Akinori Nakamura Yozo Nakazawa |
| author_facet | Naoko Shiba Yuji Inaba Mitsuo Motobayashi Makoto Nishioka Yoichiro Kawasaki Shunsuke Noda Hiroki Matsuura Norimoto Kobayashi Takafumi Matsuoka Akinori Nakamura Yozo Nakazawa |
| author_sort | Naoko Shiba |
| collection | DOAJ |
| description | Some epidemiological studies have implied a pathogenetic association between varicella zoster virus (VZV) and multiple sclerosis (MS); this, however, remains controversial. The present report describes a case involving an immunocompetent 10-year-old girl who developed relapsing-remitting MS following the prolonged reactivation of VZV inside the first branch of the trigeminal nerve, exhibiting herpes zoster ophthalmicus with severe optic neuritis. Symptoms related to herpes zoster ophthalmicus and MS appeared consecutively in the 10-week period after the appearance of vesicles. This suggests that the onset of MS was triggered by some mechanism involving VZV reactivation in the first branch of the trigeminal nerve. To the best of our knowledge, this report is the first to describe a relationship between the onset of MS and herpes zoster ophthalmicus. Early diagnosis and aggressive antiviral therapy are important in cases of herpes zoster ophthalmicus to prevent the possible development of MS as well as visual impairment as sequela. |
| format | Article |
| id | doaj-art-70a1280db548434788d399f4668e7f56 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-70a1280db548434788d399f4668e7f562025-02-03T05:43:53ZengWileyCase Reports in Pediatrics2090-68032090-68112018-01-01201810.1155/2018/69312066931206A Pediatric Case of Relapsing-Remitting Multiple Sclerosis Onset following Varicella Zoster Ophthalmicus with Optic NeuritisNaoko Shiba0Yuji Inaba1Mitsuo Motobayashi2Makoto Nishioka3Yoichiro Kawasaki4Shunsuke Noda5Hiroki Matsuura6Norimoto Kobayashi7Takafumi Matsuoka8Akinori Nakamura9Yozo Nakazawa10Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanDivision of Neurology, Nagano Children’s Hospital, Azumino, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanMatsuoka Pediatric Clinic, Matsumoto, JapanIntractable Disease Care Center, Shinshu University Hospital, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanSome epidemiological studies have implied a pathogenetic association between varicella zoster virus (VZV) and multiple sclerosis (MS); this, however, remains controversial. The present report describes a case involving an immunocompetent 10-year-old girl who developed relapsing-remitting MS following the prolonged reactivation of VZV inside the first branch of the trigeminal nerve, exhibiting herpes zoster ophthalmicus with severe optic neuritis. Symptoms related to herpes zoster ophthalmicus and MS appeared consecutively in the 10-week period after the appearance of vesicles. This suggests that the onset of MS was triggered by some mechanism involving VZV reactivation in the first branch of the trigeminal nerve. To the best of our knowledge, this report is the first to describe a relationship between the onset of MS and herpes zoster ophthalmicus. Early diagnosis and aggressive antiviral therapy are important in cases of herpes zoster ophthalmicus to prevent the possible development of MS as well as visual impairment as sequela.http://dx.doi.org/10.1155/2018/6931206 |
| spellingShingle | Naoko Shiba Yuji Inaba Mitsuo Motobayashi Makoto Nishioka Yoichiro Kawasaki Shunsuke Noda Hiroki Matsuura Norimoto Kobayashi Takafumi Matsuoka Akinori Nakamura Yozo Nakazawa A Pediatric Case of Relapsing-Remitting Multiple Sclerosis Onset following Varicella Zoster Ophthalmicus with Optic Neuritis Case Reports in Pediatrics |
| title | A Pediatric Case of Relapsing-Remitting Multiple Sclerosis Onset following Varicella Zoster Ophthalmicus with Optic Neuritis |
| title_full | A Pediatric Case of Relapsing-Remitting Multiple Sclerosis Onset following Varicella Zoster Ophthalmicus with Optic Neuritis |
| title_fullStr | A Pediatric Case of Relapsing-Remitting Multiple Sclerosis Onset following Varicella Zoster Ophthalmicus with Optic Neuritis |
| title_full_unstemmed | A Pediatric Case of Relapsing-Remitting Multiple Sclerosis Onset following Varicella Zoster Ophthalmicus with Optic Neuritis |
| title_short | A Pediatric Case of Relapsing-Remitting Multiple Sclerosis Onset following Varicella Zoster Ophthalmicus with Optic Neuritis |
| title_sort | pediatric case of relapsing remitting multiple sclerosis onset following varicella zoster ophthalmicus with optic neuritis |
| url | http://dx.doi.org/10.1155/2018/6931206 |
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