Intra-pancreatic release of bradykinin during the course experimental pancreatitis in rat
Kallikrein/Kininogn activation is an important pathophysiological event in acute pancreatitis, leading to microcirculatory changes within the gland. Hitherto, only indirect measurements of pancreatic bradykinin formation have been performed, monitoring the peptide in the circulation and in the perit...
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| Format: | Article |
| Language: | English |
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Wiley
1996-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935196000282 |
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| _version_ | 1832562272293093376 |
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| author | P. Jönsson K. Ohlsson |
| author_facet | P. Jönsson K. Ohlsson |
| author_sort | P. Jönsson |
| collection | DOAJ |
| description | Kallikrein/Kininogn activation is an important pathophysiological event in acute pancreatitis, leading to microcirculatory changes within the gland. Hitherto, only indirect measurements of pancreatic bradykinin formation have been performed, monitoring the peptide in the circulation and in the peritoneal exudate. In the present study, intra-pancreatic bradykinin release was assessed using microdialysis during experimental acute pancreatitis in rat. In mild, oedematous pancreatitis, induced by caerulein hyperstimulation, the levels of bradykinin within the gland were not elevated compared with those of control rats. However, in necrotic pancreatitis, induced by retrograde injection of taurocholate into the pancreatic duct, significantly elevated levels of intraglandular bradykinin were seen. Several rats in this group died whilst in a state of circulatory shock. |
| format | Article |
| id | doaj-art-708f99934b864b0e950c068a526f013b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1996-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-708f99934b864b0e950c068a526f013b2025-02-03T01:23:06ZengWileyMediators of Inflammation0962-93511466-18611996-01-015320220510.1155/S0962935196000282Intra-pancreatic release of bradykinin during the course experimental pancreatitis in ratP. Jönsson0K. Ohlsson1Department of Surgical Pathophysiology, University Hospital MAS, Lund University, Malmö, SwedenDepartment of Surgical Pathophysiology, University Hospital MAS, Lund University, Malmö, SwedenKallikrein/Kininogn activation is an important pathophysiological event in acute pancreatitis, leading to microcirculatory changes within the gland. Hitherto, only indirect measurements of pancreatic bradykinin formation have been performed, monitoring the peptide in the circulation and in the peritoneal exudate. In the present study, intra-pancreatic bradykinin release was assessed using microdialysis during experimental acute pancreatitis in rat. In mild, oedematous pancreatitis, induced by caerulein hyperstimulation, the levels of bradykinin within the gland were not elevated compared with those of control rats. However, in necrotic pancreatitis, induced by retrograde injection of taurocholate into the pancreatic duct, significantly elevated levels of intraglandular bradykinin were seen. Several rats in this group died whilst in a state of circulatory shock.http://dx.doi.org/10.1155/S0962935196000282 |
| spellingShingle | P. Jönsson K. Ohlsson Intra-pancreatic release of bradykinin during the course experimental pancreatitis in rat Mediators of Inflammation |
| title | Intra-pancreatic release of bradykinin during the course experimental pancreatitis in rat |
| title_full | Intra-pancreatic release of bradykinin during the course experimental pancreatitis in rat |
| title_fullStr | Intra-pancreatic release of bradykinin during the course experimental pancreatitis in rat |
| title_full_unstemmed | Intra-pancreatic release of bradykinin during the course experimental pancreatitis in rat |
| title_short | Intra-pancreatic release of bradykinin during the course experimental pancreatitis in rat |
| title_sort | intra pancreatic release of bradykinin during the course experimental pancreatitis in rat |
| url | http://dx.doi.org/10.1155/S0962935196000282 |
| work_keys_str_mv | AT pjonsson intrapancreaticreleaseofbradykininduringthecourseexperimentalpancreatitisinrat AT kohlsson intrapancreaticreleaseofbradykininduringthecourseexperimentalpancreatitisinrat |