Cannabis oil in treating Parkinson’s disease: improvement of motor and non-motor symptoms: a case report
Abstract Parkinson’s disease (PD) is characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which leads to a reduction in the production of dopamine. Medication with levodopa becomes less effective as the disease progresses. Despite the excellent results obs...
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Instituto Internacional de Ecologia
2025-01-01
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| Series: | Brazilian Journal of Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842024000101353&lng=en&tlng=en |
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| author | C. T. M. I. Issa R. D. Castro K. L. G. D. Albuquerque |
| author_facet | C. T. M. I. Issa R. D. Castro K. L. G. D. Albuquerque |
| author_sort | C. T. M. I. Issa |
| collection | DOAJ |
| description | Abstract Parkinson’s disease (PD) is characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which leads to a reduction in the production of dopamine. Medication with levodopa becomes less effective as the disease progresses. Despite the excellent results observed in clinical practice with the medicinal use of Cannabis in the treatment of PD, the level of scientific evidence is still limited due to the small number of studies published in this field. We present the case of a 77-year-old man diagnosed 22 years ago with PD in an advanced stage, with significant bradykinesia, tremor, and rigidity along with the inability to maintain an upright position and walk, exacerbated by a femur fracture. He also had advanced dysphagia, resulting in a gastrostomy. Although lucid, he showed no interest in conversation and tended to become depressed and isolated. He used Prolopa® with no satisfactory therapeutic response. After starting treatment with Cannabis sativa oil, he is now able to walk around the house frequently and eat pasty food regularly without choking or broncho-aspiration episodes. There has also been a significant improvement in non-motor symptoms; he is more active, cheerful, communicative, and attentive to his surroundings. Further studies are needed to elucidate these results and the mechanisms of action of cannabinoids through which they exert possible neuroprotective and neuroreparative effects. These compelling results suggest that cannabis oil may offer a valuable and effective therapeutic option for individuals with Parkinson's disease. |
| format | Article |
| id | doaj-art-707b67c818e647448c2e79acffe2e1a6 |
| institution | Kabale University |
| issn | 1678-4375 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Instituto Internacional de Ecologia |
| record_format | Article |
| series | Brazilian Journal of Biology |
| spelling | doaj-art-707b67c818e647448c2e79acffe2e1a62025-01-21T07:42:37ZengInstituto Internacional de EcologiaBrazilian Journal of Biology1678-43752025-01-018410.1590/1519-6984.290305Cannabis oil in treating Parkinson’s disease: improvement of motor and non-motor symptoms: a case reportC. T. M. I. Issahttps://orcid.org/0009-0008-8045-5043R. D. Castrohttps://orcid.org/0000-0001-7986-7376K. L. G. D. Albuquerquehttps://orcid.org/0000-0001-9244-5653Abstract Parkinson’s disease (PD) is characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which leads to a reduction in the production of dopamine. Medication with levodopa becomes less effective as the disease progresses. Despite the excellent results observed in clinical practice with the medicinal use of Cannabis in the treatment of PD, the level of scientific evidence is still limited due to the small number of studies published in this field. We present the case of a 77-year-old man diagnosed 22 years ago with PD in an advanced stage, with significant bradykinesia, tremor, and rigidity along with the inability to maintain an upright position and walk, exacerbated by a femur fracture. He also had advanced dysphagia, resulting in a gastrostomy. Although lucid, he showed no interest in conversation and tended to become depressed and isolated. He used Prolopa® with no satisfactory therapeutic response. After starting treatment with Cannabis sativa oil, he is now able to walk around the house frequently and eat pasty food regularly without choking or broncho-aspiration episodes. There has also been a significant improvement in non-motor symptoms; he is more active, cheerful, communicative, and attentive to his surroundings. Further studies are needed to elucidate these results and the mechanisms of action of cannabinoids through which they exert possible neuroprotective and neuroreparative effects. These compelling results suggest that cannabis oil may offer a valuable and effective therapeutic option for individuals with Parkinson's disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842024000101353&lng=en&tlng=encase reportParkinsonCannabiscannabinoids |
| spellingShingle | C. T. M. I. Issa R. D. Castro K. L. G. D. Albuquerque Cannabis oil in treating Parkinson’s disease: improvement of motor and non-motor symptoms: a case report Brazilian Journal of Biology case report Parkinson Cannabis cannabinoids |
| title | Cannabis oil in treating Parkinson’s disease: improvement of motor and non-motor symptoms: a case report |
| title_full | Cannabis oil in treating Parkinson’s disease: improvement of motor and non-motor symptoms: a case report |
| title_fullStr | Cannabis oil in treating Parkinson’s disease: improvement of motor and non-motor symptoms: a case report |
| title_full_unstemmed | Cannabis oil in treating Parkinson’s disease: improvement of motor and non-motor symptoms: a case report |
| title_short | Cannabis oil in treating Parkinson’s disease: improvement of motor and non-motor symptoms: a case report |
| title_sort | cannabis oil in treating parkinson s disease improvement of motor and non motor symptoms a case report |
| topic | case report Parkinson Cannabis cannabinoids |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842024000101353&lng=en&tlng=en |
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