Shared diagnostic genes and potential mechanisms between intervertebral disc degeneration and diabetes mellitus revealed by integrated transcriptomic analysis and machine learning

Shared diagnostic genes and potential mechanisms between intervertebral disc degeneration and diabetes mellitus revealed by integrated transcriptomic analysis and machine learning

IntroductionIntervertebral disc degeneration (IDD) and diabetes mellitus (DM) are clinically associated beyond traditional risk factors, yet the shared molecular mechanisms remain unclear.MethodsWe integrated transcriptomic data from IDD and DM cohorts, performed differential expression and protein–...

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Bibliographic Details
Main Authors: Bao Song, Jianmin Wang, Hao Tang, Huadong Li, Wanli Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Endocrinology
Subjects:
intervertebral disc degeneration
diabetes mellitus
PRTN3
diagnostic
immune infiltration
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1576826/full
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