Effect of a Ketogenic Diet on Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) Progression: A Randomized Controlled Trial
ABSTRACT Background Despite the popularity of a ketogenic diet, no randomized, controlled trials have evaluated its efficacy on metabolic dysfunction‐associated steatotic liver disease (MASLD) progression. Methods We conducted an 8‐week, open‐label, randomized controlled trial involving 24 patients...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.70099 |
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| author | Sakkarin Chirapongsathorn Wiwit Rintaravitoon Bhagawat Tangjaturonrasme Samitti Chotsriluecha Yanisa Pumsutas Achariya Kanchanapradith Sombat Treeprasertsuk |
| author_facet | Sakkarin Chirapongsathorn Wiwit Rintaravitoon Bhagawat Tangjaturonrasme Samitti Chotsriluecha Yanisa Pumsutas Achariya Kanchanapradith Sombat Treeprasertsuk |
| author_sort | Sakkarin Chirapongsathorn |
| collection | DOAJ |
| description | ABSTRACT Background Despite the popularity of a ketogenic diet, no randomized, controlled trials have evaluated its efficacy on metabolic dysfunction‐associated steatotic liver disease (MASLD) progression. Methods We conducted an 8‐week, open‐label, randomized controlled trial involving 24 patients with MASLD who were randomly assigned to either the home delivery ketogenic diet or a nutrition education program on adherence to the DASH diet. The primary outcome was a reduction in hepatic steatosis as measured by transient elastography. Results There were no significant differences between groups in liver stiffness and steatosis measurement after interventions. Subjects on a ketogenic diet had lost more weight than subjects in the control group at 8 weeks (mean change [95% CI], −6.16 [−7.22, −5.10] vs. −2.14 [−4.49, 0.21] kg; p = 0.001). The decrease in waist circumference, systolic blood pressure, fat mass, and visceral fat area was significantly greater among subjects on a ketogenic diet than among those in the control group. Laboratory parameters, including AST, triglyceride, and HDL were also significantly decreased among subjects on a ketogenic diet than among those in the control group. Conclusions A ketogenic diet produced a significantly greater weight loss (absolute difference, approximately 4%) than did the general lifestyle advice intervention for the first 8 weeks. A ketogenic diet was associated with a greater improvement in some risk factors for coronary heart disease and MASLD. However, a ketogenic diet did not reduce steatosis nor worsen MASLD progression. Longer and larger studies are required to determine the long‐term safety and efficacy of the ketogenic diet. Trial Registration: TCTR20220426005 |
| format | Article |
| id | doaj-art-7055150ee73242d09f980bdffb0dad10 |
| institution | Kabale University |
| issn | 2397-9070 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj-art-7055150ee73242d09f980bdffb0dad102025-01-28T09:24:32ZengWileyJGH Open2397-90702025-01-0191n/an/a10.1002/jgh3.70099Effect of a Ketogenic Diet on Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) Progression: A Randomized Controlled TrialSakkarin Chirapongsathorn0Wiwit Rintaravitoon1Bhagawat Tangjaturonrasme2Samitti Chotsriluecha3Yanisa Pumsutas4Achariya Kanchanapradith5Sombat Treeprasertsuk6Division of Gastroenterology and Hepatology, Department of Medicine Phramongkutklao Hospital and College of Medicine Bangkok ThailandDivision of Gastroenterology and Hepatology, Department of Medicine Phramongkutklao Hospital and College of Medicine Bangkok ThailandDivision of Clinical Nutrition, Department of Medicine Phramongkutklao Hospital and College of Medicine Bangkok ThailandDivision of Clinical Nutrition, Department of Medicine Phramongkutklao Hospital and College of Medicine Bangkok ThailandDivision of Clinical Nutrition, Department of Medicine Phramongkutklao Hospital and College of Medicine Bangkok ThailandDivision of Gastroenterology and Hepatology, Department of Medicine Phramongkutklao Hospital and College of Medicine Bangkok ThailandDivision of Gastroenterology, Department of Medicine Chulalongkorn University Bangkok ThailandABSTRACT Background Despite the popularity of a ketogenic diet, no randomized, controlled trials have evaluated its efficacy on metabolic dysfunction‐associated steatotic liver disease (MASLD) progression. Methods We conducted an 8‐week, open‐label, randomized controlled trial involving 24 patients with MASLD who were randomly assigned to either the home delivery ketogenic diet or a nutrition education program on adherence to the DASH diet. The primary outcome was a reduction in hepatic steatosis as measured by transient elastography. Results There were no significant differences between groups in liver stiffness and steatosis measurement after interventions. Subjects on a ketogenic diet had lost more weight than subjects in the control group at 8 weeks (mean change [95% CI], −6.16 [−7.22, −5.10] vs. −2.14 [−4.49, 0.21] kg; p = 0.001). The decrease in waist circumference, systolic blood pressure, fat mass, and visceral fat area was significantly greater among subjects on a ketogenic diet than among those in the control group. Laboratory parameters, including AST, triglyceride, and HDL were also significantly decreased among subjects on a ketogenic diet than among those in the control group. Conclusions A ketogenic diet produced a significantly greater weight loss (absolute difference, approximately 4%) than did the general lifestyle advice intervention for the first 8 weeks. A ketogenic diet was associated with a greater improvement in some risk factors for coronary heart disease and MASLD. However, a ketogenic diet did not reduce steatosis nor worsen MASLD progression. Longer and larger studies are required to determine the long‐term safety and efficacy of the ketogenic diet. Trial Registration: TCTR20220426005https://doi.org/10.1002/jgh3.70099ketogenic dietMASLDmetabolic dysfunction‐associated steatotic liver disease |
| spellingShingle | Sakkarin Chirapongsathorn Wiwit Rintaravitoon Bhagawat Tangjaturonrasme Samitti Chotsriluecha Yanisa Pumsutas Achariya Kanchanapradith Sombat Treeprasertsuk Effect of a Ketogenic Diet on Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) Progression: A Randomized Controlled Trial JGH Open ketogenic diet MASLD metabolic dysfunction‐associated steatotic liver disease |
| title | Effect of a Ketogenic Diet on Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) Progression: A Randomized Controlled Trial |
| title_full | Effect of a Ketogenic Diet on Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) Progression: A Randomized Controlled Trial |
| title_fullStr | Effect of a Ketogenic Diet on Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) Progression: A Randomized Controlled Trial |
| title_full_unstemmed | Effect of a Ketogenic Diet on Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) Progression: A Randomized Controlled Trial |
| title_short | Effect of a Ketogenic Diet on Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) Progression: A Randomized Controlled Trial |
| title_sort | effect of a ketogenic diet on metabolic dysfunction associated steatotic liver disease masld progression a randomized controlled trial |
| topic | ketogenic diet MASLD metabolic dysfunction‐associated steatotic liver disease |
| url | https://doi.org/10.1002/jgh3.70099 |
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