Plasma Fatty Acids in Zambian Adults with HIV/AIDS: Relation to Dietary Intake and Cardiovascular Risk Factors
Objective. To determine whether 24 hr dietary recalls (DR) are a good measure of polyunsaturated fatty acid (PUFA) intake when compared to plasma levels, and whether plasma PUFA is associated with markers of HIV/AIDS progression and cardiovascular disease (CVD) risk. Methods. In a cross-sectional st...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2015/635817 |
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| author | Christopher K. Nyirenda Edmond K. Kabagambe John R. Koethe James N. Kiage Benjamin H. Chi Patrick Musonda Meridith Blevins Claire N. Bosire Michael Y. Tsai Douglas C. Heimburger |
| author_facet | Christopher K. Nyirenda Edmond K. Kabagambe John R. Koethe James N. Kiage Benjamin H. Chi Patrick Musonda Meridith Blevins Claire N. Bosire Michael Y. Tsai Douglas C. Heimburger |
| author_sort | Christopher K. Nyirenda |
| collection | DOAJ |
| description | Objective. To determine whether 24 hr dietary recalls (DR) are a good measure of polyunsaturated fatty acid (PUFA) intake when compared to plasma levels, and whether plasma PUFA is associated with markers of HIV/AIDS progression and cardiovascular disease (CVD) risk. Methods. In a cross-sectional study among 210 antiretroviral therapy-naïve HIV-infected adults from Lusaka, Zambia, we collected data on medical history and dietary intake using 24 hr DR. We measured fatty acids and markers of AIDS progression and CVD risk in fasting plasma collected at baseline. Results. PUFA intakes showed modest correlations with corresponding plasma levels; Spearman correlations were 0.36 (p<0.01) for eicosapentaenoic acid and 0.21 (p=0.005) for docosahexaenoic acid. While there were no significant associations (p>0.05) between total plasma PUFA and C-reactive protein (CRP) or lipid levels, plasma arachidonic acid was inversely associated with CRP and triglycerides and positively associated with HDL-C, CD4+ T-cell count, and plasma albumin (p<0.05). Plasma saturated fatty acids (SFA) were positively associated with CRP (β = 0.24; 95% CI: 0.08 to 0.40, p=0.003) and triglycerides (β = 0.08; 95% CI: 0.03 to 0.12, p<0.01). Conclusions. Our data suggest that a single DR is inadequate for assessing PUFA intake and that plasma arachidonic acid levels may modulate HIV/AIDS progression and CVD risk. |
| format | Article |
| id | doaj-art-705205e72a5f48b29bbc55e041ae8c59 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-705205e72a5f48b29bbc55e041ae8c592025-02-03T05:58:05ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322015-01-01201510.1155/2015/635817635817Plasma Fatty Acids in Zambian Adults with HIV/AIDS: Relation to Dietary Intake and Cardiovascular Risk FactorsChristopher K. Nyirenda0Edmond K. Kabagambe1John R. Koethe2James N. Kiage3Benjamin H. Chi4Patrick Musonda5Meridith Blevins6Claire N. Bosire7Michael Y. Tsai8Douglas C. Heimburger9Ndola Central Hospital, School of Medicine, 10101 Ndola, ZambiaVanderbilt Institute for Global Health, Vanderbilt University, Nashville, TN 37203, USAVanderbilt Institute for Global Health, Vanderbilt University, Nashville, TN 37203, USADivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37203, USACentre for Infectious Disease Research in Zambia, 10101 Lusaka, ZambiaCentre for Infectious Disease Research in Zambia, 10101 Lusaka, ZambiaVanderbilt Institute for Global Health, Vanderbilt University, Nashville, TN 37203, USADivision of Cancer Epidemiology and Genetics, National Cancer Institute, Nutritional Epidemiology Branch, Bethesda, MD 20850, USADepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USAVanderbilt Institute for Global Health, Vanderbilt University, Nashville, TN 37203, USAObjective. To determine whether 24 hr dietary recalls (DR) are a good measure of polyunsaturated fatty acid (PUFA) intake when compared to plasma levels, and whether plasma PUFA is associated with markers of HIV/AIDS progression and cardiovascular disease (CVD) risk. Methods. In a cross-sectional study among 210 antiretroviral therapy-naïve HIV-infected adults from Lusaka, Zambia, we collected data on medical history and dietary intake using 24 hr DR. We measured fatty acids and markers of AIDS progression and CVD risk in fasting plasma collected at baseline. Results. PUFA intakes showed modest correlations with corresponding plasma levels; Spearman correlations were 0.36 (p<0.01) for eicosapentaenoic acid and 0.21 (p=0.005) for docosahexaenoic acid. While there were no significant associations (p>0.05) between total plasma PUFA and C-reactive protein (CRP) or lipid levels, plasma arachidonic acid was inversely associated with CRP and triglycerides and positively associated with HDL-C, CD4+ T-cell count, and plasma albumin (p<0.05). Plasma saturated fatty acids (SFA) were positively associated with CRP (β = 0.24; 95% CI: 0.08 to 0.40, p=0.003) and triglycerides (β = 0.08; 95% CI: 0.03 to 0.12, p<0.01). Conclusions. Our data suggest that a single DR is inadequate for assessing PUFA intake and that plasma arachidonic acid levels may modulate HIV/AIDS progression and CVD risk.http://dx.doi.org/10.1155/2015/635817 |
| spellingShingle | Christopher K. Nyirenda Edmond K. Kabagambe John R. Koethe James N. Kiage Benjamin H. Chi Patrick Musonda Meridith Blevins Claire N. Bosire Michael Y. Tsai Douglas C. Heimburger Plasma Fatty Acids in Zambian Adults with HIV/AIDS: Relation to Dietary Intake and Cardiovascular Risk Factors Journal of Nutrition and Metabolism |
| title | Plasma Fatty Acids in Zambian Adults with HIV/AIDS: Relation to Dietary Intake and Cardiovascular Risk Factors |
| title_full | Plasma Fatty Acids in Zambian Adults with HIV/AIDS: Relation to Dietary Intake and Cardiovascular Risk Factors |
| title_fullStr | Plasma Fatty Acids in Zambian Adults with HIV/AIDS: Relation to Dietary Intake and Cardiovascular Risk Factors |
| title_full_unstemmed | Plasma Fatty Acids in Zambian Adults with HIV/AIDS: Relation to Dietary Intake and Cardiovascular Risk Factors |
| title_short | Plasma Fatty Acids in Zambian Adults with HIV/AIDS: Relation to Dietary Intake and Cardiovascular Risk Factors |
| title_sort | plasma fatty acids in zambian adults with hiv aids relation to dietary intake and cardiovascular risk factors |
| url | http://dx.doi.org/10.1155/2015/635817 |
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