Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of Psoriasis
Psoriasis is a chronic, recurrent and inflammatory skin disease. Although conventional immunosuppressants can ameliorate psoriatic symptoms, it tends to relapse over time. Previous studies have shown that exosomes from both immune and non-immune cells participate in psoriatic immunopathology. The bi...
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| Format: | Article |
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2025-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/1/51 |
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| author | Yuchao Chen Huazhen Liu Yuming He Bin Yang Weihui Lu Zhenhua Dai |
| author_facet | Yuchao Chen Huazhen Liu Yuming He Bin Yang Weihui Lu Zhenhua Dai |
| author_sort | Yuchao Chen |
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| description | Psoriasis is a chronic, recurrent and inflammatory skin disease. Although conventional immunosuppressants can ameliorate psoriatic symptoms, it tends to relapse over time. Previous studies have shown that exosomes from both immune and non-immune cells participate in psoriatic immunopathology. The biologically active cargoes in exosomes accelerate psoriasis progression by altering gene profiles and signaling pathways of neighboring cells. On the other hand, exosomes can be utilized as drug delivery platforms for psoriasis treatment. Especially, engineered exosomes may serve as drug delivery systems for effective delivery of proteins, nucleic acids or other drugs due to their low immunogenicity, good stability and ability to fuse with target cells. Therefore, investigation into the mechanisms underlying intercellular communications mediated by exosomes in skin lesions likely helps design drugs for therapy of psoriasis. In this review, we have summarized recent advances in the biogenesis of exosomes and their potential roles in the pathogenesis and treatment of psoriasis and further discussed their challenges and future directions in psoriasis treatment. In particular, this review highlights the immunoregulatory function of exosomes derived from immune or non-immune cells and exosome-based therapeutic applications in psoriasis, including their drug delivery systems. Thus, this review may help accelerate applications of exosomes for drug delivery and treatment of psoriasis. |
| format | Article |
| id | doaj-art-704a57cf26d3460cb213ae50d8f55e2f |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-704a57cf26d3460cb213ae50d8f55e2f2025-01-24T13:45:43ZengMDPI AGPharmaceutics1999-49232025-01-011715110.3390/pharmaceutics17010051Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of PsoriasisYuchao Chen0Huazhen Liu1Yuming He2Bin Yang3Weihui Lu4Zhenhua Dai5Section of Immunology, Guangdong Provincial Academy of Chinese Medical Sciences, 55 Nei Huan Xi Lu, College Town, Guangzhou 510006, ChinaSection of Immunology, Guangdong Provincial Academy of Chinese Medical Sciences, 55 Nei Huan Xi Lu, College Town, Guangzhou 510006, ChinaState Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaDepartment of Cardiovascular Sciences, College of Life Sciences, University of Leicester, Leicester LE1 9HN, UKSection of Immunology, Guangdong Provincial Academy of Chinese Medical Sciences, 55 Nei Huan Xi Lu, College Town, Guangzhou 510006, ChinaSection of Immunology, Guangdong Provincial Academy of Chinese Medical Sciences, 55 Nei Huan Xi Lu, College Town, Guangzhou 510006, ChinaPsoriasis is a chronic, recurrent and inflammatory skin disease. Although conventional immunosuppressants can ameliorate psoriatic symptoms, it tends to relapse over time. Previous studies have shown that exosomes from both immune and non-immune cells participate in psoriatic immunopathology. The biologically active cargoes in exosomes accelerate psoriasis progression by altering gene profiles and signaling pathways of neighboring cells. On the other hand, exosomes can be utilized as drug delivery platforms for psoriasis treatment. Especially, engineered exosomes may serve as drug delivery systems for effective delivery of proteins, nucleic acids or other drugs due to their low immunogenicity, good stability and ability to fuse with target cells. Therefore, investigation into the mechanisms underlying intercellular communications mediated by exosomes in skin lesions likely helps design drugs for therapy of psoriasis. In this review, we have summarized recent advances in the biogenesis of exosomes and their potential roles in the pathogenesis and treatment of psoriasis and further discussed their challenges and future directions in psoriasis treatment. In particular, this review highlights the immunoregulatory function of exosomes derived from immune or non-immune cells and exosome-based therapeutic applications in psoriasis, including their drug delivery systems. Thus, this review may help accelerate applications of exosomes for drug delivery and treatment of psoriasis.https://www.mdpi.com/1999-4923/17/1/51drug deliveryexosomespsoriasisimmunoregulationmolecular biology |
| spellingShingle | Yuchao Chen Huazhen Liu Yuming He Bin Yang Weihui Lu Zhenhua Dai Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of Psoriasis Pharmaceutics drug delivery exosomes psoriasis immunoregulation molecular biology |
| title | Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of Psoriasis |
| title_full | Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of Psoriasis |
| title_fullStr | Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of Psoriasis |
| title_full_unstemmed | Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of Psoriasis |
| title_short | Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of Psoriasis |
| title_sort | roles for exosomes in the pathogenesis drug delivery and therapy of psoriasis |
| topic | drug delivery exosomes psoriasis immunoregulation molecular biology |
| url | https://www.mdpi.com/1999-4923/17/1/51 |
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