Diet-Induced Swine Model with Obesity/Leptin Resistance for the Study of Metabolic Syndrome and Type 2 Diabetes
The objective of the present study was to determine the suitability of a swine breed with leptin resistance and predisposition to obesity (the Iberian pig) as model for studies on metabolic syndrome and type 2 diabetes. Thus, six Iberian sows had ad libitum access to food enriched with saturated fat...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/510149 |
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| author | L. Torres-Rovira S. Astiz A. Caro C. Lopez-Bote C. Ovilo P. Pallares M. L. Perez-Solana R. Sanchez-Sanchez A. Gonzalez-Bulnes |
| author_facet | L. Torres-Rovira S. Astiz A. Caro C. Lopez-Bote C. Ovilo P. Pallares M. L. Perez-Solana R. Sanchez-Sanchez A. Gonzalez-Bulnes |
| author_sort | L. Torres-Rovira |
| collection | DOAJ |
| description | The objective of the present study was to determine the suitability of a swine breed with leptin resistance and predisposition to obesity (the Iberian pig) as model for studies on metabolic syndrome and type 2 diabetes. Thus, six Iberian sows had ad libitum access to food enriched with saturated fat (SFAD group; food consumption was estimated to be 4.5 kg/animal/day) whilst four females acted as controls and were fed with 2 kg/animal/day of a commercial maintenance diet. After three months of differential feeding, SFAD animals developed central obesity, dyslipidemia, insulin resistance and impaired glucose tolerance, and elevated blood pressure; the five parameters associated with the metabolic syndrome. Thus, the current study characterizes the Iberian pig as a robust, amenable, and reliable translational model for studies on nutrition-associated diseases. |
| format | Article |
| id | doaj-art-7032f26d309a4253810955ec6eafe50a |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7032f26d309a4253810955ec6eafe50a2025-02-03T01:24:03ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/510149510149Diet-Induced Swine Model with Obesity/Leptin Resistance for the Study of Metabolic Syndrome and Type 2 DiabetesL. Torres-Rovira0S. Astiz1A. Caro2C. Lopez-Bote3C. Ovilo4P. Pallares5M. L. Perez-Solana6R. Sanchez-Sanchez7A. Gonzalez-Bulnes8Departamento de Reproducción Animal, INIA, 28040 Madrid, SpainDepartamento de Reproducción Animal, INIA, 28040 Madrid, SpainDepartamento de Medicina y Cirugía Animal, Facultad de Veterinaria, UCM, 28040 Madrid, SpainDepartamento de Producción Animal, Facultad de Veterinaria, UCM, 28040 Madrid, SpainDepartamento de Mejora Genetica Animal, INIA, 28040 Madrid, SpainDepartamento de Reproducción Animal, INIA, 28040 Madrid, SpainDepartamento de Reproducción Animal, INIA, 28040 Madrid, SpainDepartamento de Reproducción Animal, INIA, 28040 Madrid, SpainDepartamento de Reproducción Animal, INIA, 28040 Madrid, SpainThe objective of the present study was to determine the suitability of a swine breed with leptin resistance and predisposition to obesity (the Iberian pig) as model for studies on metabolic syndrome and type 2 diabetes. Thus, six Iberian sows had ad libitum access to food enriched with saturated fat (SFAD group; food consumption was estimated to be 4.5 kg/animal/day) whilst four females acted as controls and were fed with 2 kg/animal/day of a commercial maintenance diet. After three months of differential feeding, SFAD animals developed central obesity, dyslipidemia, insulin resistance and impaired glucose tolerance, and elevated blood pressure; the five parameters associated with the metabolic syndrome. Thus, the current study characterizes the Iberian pig as a robust, amenable, and reliable translational model for studies on nutrition-associated diseases.http://dx.doi.org/10.1100/2012/510149 |
| spellingShingle | L. Torres-Rovira S. Astiz A. Caro C. Lopez-Bote C. Ovilo P. Pallares M. L. Perez-Solana R. Sanchez-Sanchez A. Gonzalez-Bulnes Diet-Induced Swine Model with Obesity/Leptin Resistance for the Study of Metabolic Syndrome and Type 2 Diabetes The Scientific World Journal |
| title | Diet-Induced Swine Model with Obesity/Leptin Resistance for the Study of Metabolic Syndrome and Type 2 Diabetes |
| title_full | Diet-Induced Swine Model with Obesity/Leptin Resistance for the Study of Metabolic Syndrome and Type 2 Diabetes |
| title_fullStr | Diet-Induced Swine Model with Obesity/Leptin Resistance for the Study of Metabolic Syndrome and Type 2 Diabetes |
| title_full_unstemmed | Diet-Induced Swine Model with Obesity/Leptin Resistance for the Study of Metabolic Syndrome and Type 2 Diabetes |
| title_short | Diet-Induced Swine Model with Obesity/Leptin Resistance for the Study of Metabolic Syndrome and Type 2 Diabetes |
| title_sort | diet induced swine model with obesity leptin resistance for the study of metabolic syndrome and type 2 diabetes |
| url | http://dx.doi.org/10.1100/2012/510149 |
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