Molecular Epidemiology of Enteric Adenovirus Gastroenteritis in under-Five-Year-Old Children in Iran
Background. Acute gastroenteritis is one of the major sources of morbidity and mortality among young children in developed and developing countries. The aim of this study was to determine the prevalence of human adenovirus- (HAdV-) 40 and HAdV-41 in children hospitalized with gastroenteritis in five...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/2045697 |
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| author | Anahita Sanaei Dashti Pedram Ghahremani Tayebeh Hashempoor Abdollah Karimi |
| author_facet | Anahita Sanaei Dashti Pedram Ghahremani Tayebeh Hashempoor Abdollah Karimi |
| author_sort | Anahita Sanaei Dashti |
| collection | DOAJ |
| description | Background. Acute gastroenteritis is one of the major sources of morbidity and mortality among young children in developed and developing countries. The aim of this study was to determine the prevalence of human adenovirus- (HAdV-) 40 and HAdV-41 in children hospitalized with gastroenteritis in five different health centers of Iran. Methods. In a cross-sectional epidemiological study, we studied 2682 fecal specimens that were collected from children under the age of 5 years in five educational and therapeutic pediatric centers in Iran from February 2012 to February 2013. Samples were tested for HAdV-40 and HAdV-41, using a specific pair of primers in polymerase chain reaction (PCR) method. Results. HAdV-40 and HAdV-41 were detected in 132 (5.18%) of the patients with diarrhea. A significantly higher prevalence of HAdV-40 and HAdV-41 (58.3%) was observed in children under 12 months of age, compared to other age groups. The male to female ratio was 1.7. Conclusion. The results of this study demonstrated that HAdV-40 and HAdV-41 could be considered etiological agents for acute gastroenteritis among children in Iran. The PCR as a rapid test may increase the chance for a relatively mild course of the disease followed by a complete recovery and avoiding administration of unnecessary antibiotics. |
| format | Article |
| id | doaj-art-703240cf0daf4d489b6c2478a3aff983 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-703240cf0daf4d489b6c2478a3aff9832025-02-03T01:11:18ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/20456972045697Molecular Epidemiology of Enteric Adenovirus Gastroenteritis in under-Five-Year-Old Children in IranAnahita Sanaei Dashti0Pedram Ghahremani1Tayebeh Hashempoor2Abdollah Karimi3Shiraz HIV/AIDS Research Center, Shiraz University of Medical Sciences, Shiraz 7193613311, IranPediatric Infectious Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranProfessor Alborzi Clinical Microbiology Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz 7193613311, IranPediatric Infectious Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranBackground. Acute gastroenteritis is one of the major sources of morbidity and mortality among young children in developed and developing countries. The aim of this study was to determine the prevalence of human adenovirus- (HAdV-) 40 and HAdV-41 in children hospitalized with gastroenteritis in five different health centers of Iran. Methods. In a cross-sectional epidemiological study, we studied 2682 fecal specimens that were collected from children under the age of 5 years in five educational and therapeutic pediatric centers in Iran from February 2012 to February 2013. Samples were tested for HAdV-40 and HAdV-41, using a specific pair of primers in polymerase chain reaction (PCR) method. Results. HAdV-40 and HAdV-41 were detected in 132 (5.18%) of the patients with diarrhea. A significantly higher prevalence of HAdV-40 and HAdV-41 (58.3%) was observed in children under 12 months of age, compared to other age groups. The male to female ratio was 1.7. Conclusion. The results of this study demonstrated that HAdV-40 and HAdV-41 could be considered etiological agents for acute gastroenteritis among children in Iran. The PCR as a rapid test may increase the chance for a relatively mild course of the disease followed by a complete recovery and avoiding administration of unnecessary antibiotics.http://dx.doi.org/10.1155/2016/2045697 |
| spellingShingle | Anahita Sanaei Dashti Pedram Ghahremani Tayebeh Hashempoor Abdollah Karimi Molecular Epidemiology of Enteric Adenovirus Gastroenteritis in under-Five-Year-Old Children in Iran Gastroenterology Research and Practice |
| title | Molecular Epidemiology of Enteric Adenovirus Gastroenteritis in under-Five-Year-Old Children in Iran |
| title_full | Molecular Epidemiology of Enteric Adenovirus Gastroenteritis in under-Five-Year-Old Children in Iran |
| title_fullStr | Molecular Epidemiology of Enteric Adenovirus Gastroenteritis in under-Five-Year-Old Children in Iran |
| title_full_unstemmed | Molecular Epidemiology of Enteric Adenovirus Gastroenteritis in under-Five-Year-Old Children in Iran |
| title_short | Molecular Epidemiology of Enteric Adenovirus Gastroenteritis in under-Five-Year-Old Children in Iran |
| title_sort | molecular epidemiology of enteric adenovirus gastroenteritis in under five year old children in iran |
| url | http://dx.doi.org/10.1155/2016/2045697 |
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