Associations of Serum Urate and Cardiovascular Events in a Clinical Trial of Interleukin-1β Blockade

Associations of Serum Urate and Cardiovascular Events in a Clinical Trial of Interleukin-1β Blockade

Background: Serum urate (SU) associates with cardiovascular (CV) events, mortality, and gout. Objectives: The purpose of this study was to assess whether SU predicts CV risk in a trial of interleukin (IL)-1β inhibition with canakinumab, and whether IL-1β blockade, kidney function, or gout alter thes...

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Main Authors: Nicholas H. Adamstein, MD, Jean G. MacFadyen, BA, Brittany N. Weber, MD, PhD, Peter Libby, MD, Daniel H. Solomon, MD, MPH, Paul M Ridker, MD, MPH
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:JACC: Advances
Subjects:
serum urate
atherosclerosis
major adverse cardiovascular events
inflammation
cytokines
gout
Online Access:http://www.sciencedirect.com/science/article/pii/S2772963X24008640
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