Kounis Syndrome as First Manifestation of Allergic Sensitization
Mast cells are abundant in the heart, among myocardial fibers, around coronary arteries, within arterial intima and intramural vessels, and in atherosclerotic plaques. Their mediators can be released during anaphylaxis and be responsible for acute coronary syndrome. This condition has been described...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/6317956 |
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| author | D. Forlani G. Scarano A. D’Alleva M. Di Marco L. Paloscia A. Gatta L. Della Valle A. Farinelli A. Lumaca C. Petrarca R. Paganelli L. Di Giampaolo M. Di Gioacchino |
| author_facet | D. Forlani G. Scarano A. D’Alleva M. Di Marco L. Paloscia A. Gatta L. Della Valle A. Farinelli A. Lumaca C. Petrarca R. Paganelli L. Di Giampaolo M. Di Gioacchino |
| author_sort | D. Forlani |
| collection | DOAJ |
| description | Mast cells are abundant in the heart, among myocardial fibers, around coronary arteries, within arterial intima and intramural vessels, and in atherosclerotic plaques. Their mediators can be released during anaphylaxis and be responsible for acute coronary syndrome. This condition has been described as Kounis syndrome (KS). We report three cases of acute myocardial ischemia, which fulfill the definition for KS. In Cases 1 and 2, the association of intense chest pain with acute urticaria after an allergenic contact (wasp sting and betalactam antibiotic administration, respectively) was suspected to be an attack of angina related to an allergic reaction. No signs of an allergic reaction were observed in Case 3, but only the history of a wasp sting suggested its relationship to loss of consciousness and heart ischemia when hypersensitivity to venom was ascertained. These cases strongly recommend measurement of anaphylactic biomarkers, such as tryptase, during acute coronary syndromes to detect the possible involvement of an allergic reaction. Conversely, measurement of cardiac biomarkers during anaphylaxis, even without obvious signs of myocardial ischemia, might identify patients at risk of myocardial injury. |
| format | Article |
| id | doaj-art-70247effb1384f27bbb2f5e4b09c551e |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-70247effb1384f27bbb2f5e4b09c551e2025-02-03T06:13:41ZengWileyCase Reports in Medicine1687-96271687-96352019-01-01201910.1155/2019/63179566317956Kounis Syndrome as First Manifestation of Allergic SensitizationD. Forlani0G. Scarano1A. D’Alleva2M. Di Marco3L. Paloscia4A. Gatta5L. Della Valle6A. Farinelli7A. Lumaca8C. Petrarca9R. Paganelli10L. Di Giampaolo11M. Di Gioacchino12Intensive Coronary Unit and Interventional Cardiology, “Spirito Santo” Hospital, Pescara, ItalyImmunotoxicology and Allergy Unit, CeSI-Met, G. d’Annunzio University, Chieti, ItalyIntensive Coronary Unit and Interventional Cardiology, “Spirito Santo” Hospital, Pescara, ItalyIntensive Coronary Unit and Interventional Cardiology, “Spirito Santo” Hospital, Pescara, ItalyIntensive Coronary Unit and Interventional Cardiology, “Spirito Santo” Hospital, Pescara, ItalyImmunotoxicology and Allergy Unit, CeSI-Met, G. d’Annunzio University, Chieti, ItalyImmunotoxicology and Allergy Unit, CeSI-Met, G. d’Annunzio University, Chieti, ItalyImmunotoxicology and Allergy Unit, CeSI-Met, G. d’Annunzio University, Chieti, ItalyImmunotoxicology and Allergy Unit, CeSI-Met, G. d’Annunzio University, Chieti, ItalyImmunotoxicology and Allergy Unit, CeSI-Met, G. d’Annunzio University, Chieti, ItalyImmunotoxicology and Allergy Unit, CeSI-Met, G. d’Annunzio University, Chieti, ItalyImmunotoxicology and Allergy Unit, CeSI-Met, G. d’Annunzio University, Chieti, ItalyImmunotoxicology and Allergy Unit, CeSI-Met, G. d’Annunzio University, Chieti, ItalyMast cells are abundant in the heart, among myocardial fibers, around coronary arteries, within arterial intima and intramural vessels, and in atherosclerotic plaques. Their mediators can be released during anaphylaxis and be responsible for acute coronary syndrome. This condition has been described as Kounis syndrome (KS). We report three cases of acute myocardial ischemia, which fulfill the definition for KS. In Cases 1 and 2, the association of intense chest pain with acute urticaria after an allergenic contact (wasp sting and betalactam antibiotic administration, respectively) was suspected to be an attack of angina related to an allergic reaction. No signs of an allergic reaction were observed in Case 3, but only the history of a wasp sting suggested its relationship to loss of consciousness and heart ischemia when hypersensitivity to venom was ascertained. These cases strongly recommend measurement of anaphylactic biomarkers, such as tryptase, during acute coronary syndromes to detect the possible involvement of an allergic reaction. Conversely, measurement of cardiac biomarkers during anaphylaxis, even without obvious signs of myocardial ischemia, might identify patients at risk of myocardial injury.http://dx.doi.org/10.1155/2019/6317956 |
| spellingShingle | D. Forlani G. Scarano A. D’Alleva M. Di Marco L. Paloscia A. Gatta L. Della Valle A. Farinelli A. Lumaca C. Petrarca R. Paganelli L. Di Giampaolo M. Di Gioacchino Kounis Syndrome as First Manifestation of Allergic Sensitization Case Reports in Medicine |
| title | Kounis Syndrome as First Manifestation of Allergic Sensitization |
| title_full | Kounis Syndrome as First Manifestation of Allergic Sensitization |
| title_fullStr | Kounis Syndrome as First Manifestation of Allergic Sensitization |
| title_full_unstemmed | Kounis Syndrome as First Manifestation of Allergic Sensitization |
| title_short | Kounis Syndrome as First Manifestation of Allergic Sensitization |
| title_sort | kounis syndrome as first manifestation of allergic sensitization |
| url | http://dx.doi.org/10.1155/2019/6317956 |
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