Genetic Risk Score Predicts Late-Life Cognitive Impairment
Introduction. A family history of Alzheimer’s disease is a significant risk factor for its onset, but the genetic risk associated with possessing multiple risk alleles is still poorly understood. Methods. In a sample of 95 older adults (Mean age = 75.1, 64.2% female), we constructed a genetic risk s...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2015/267062 |
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| author | Mariegold E. Wollam Andrea M. Weinstein Judith A. Saxton Lisa Morrow Beth Snitz Nicole R. Fowler Barbara L. Suever Erickson Kathryn A. Roecklein Kirk I. Erickson |
| author_facet | Mariegold E. Wollam Andrea M. Weinstein Judith A. Saxton Lisa Morrow Beth Snitz Nicole R. Fowler Barbara L. Suever Erickson Kathryn A. Roecklein Kirk I. Erickson |
| author_sort | Mariegold E. Wollam |
| collection | DOAJ |
| description | Introduction. A family history of Alzheimer’s disease is a significant risk factor for its onset, but the genetic risk associated with possessing multiple risk alleles is still poorly understood. Methods. In a sample of 95 older adults (Mean age = 75.1, 64.2% female), we constructed a genetic risk score based on the accumulation of risk alleles in BDNF, COMT, and APOE. A neuropsychological evaluation and consensus determined cognitive status (44 nonimpaired, 51 impaired). Logistic regression was performed to determine whether the genetic risk score predicted cognitive impairment above and beyond that associated with each gene. Results. An increased genetic risk score was associated with a nearly 4-fold increased risk of cognitive impairment (OR = 3.824, P = .013) when including the individual gene polymorphisms as covariates in the model. Discussion. A risk score combining multiple genetic influences may be more useful in predicting late-life cognitive impairment than individual polymorphisms. |
| format | Article |
| id | doaj-art-701ef8566ac440f99a11e6708dc141ba |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-701ef8566ac440f99a11e6708dc141ba2025-02-03T01:11:00ZengWileyJournal of Aging Research2090-22042090-22122015-01-01201510.1155/2015/267062267062Genetic Risk Score Predicts Late-Life Cognitive ImpairmentMariegold E. Wollam0Andrea M. Weinstein1Judith A. Saxton2Lisa Morrow3Beth Snitz4Nicole R. Fowler5Barbara L. Suever Erickson6Kathryn A. Roecklein7Kirk I. Erickson8Department of Psychology, University of Pittsburgh, Sennott Square, 3rd Floor, 210 South Bouquet Street, Pittsburgh, PA 15260, USADepartment of Psychology, University of Pittsburgh, Sennott Square, 3rd Floor, 210 South Bouquet Street, Pittsburgh, PA 15260, USADepartment of Neurology, University of Pittsburgh, 811 Kaufmann Medical Building, 3471 Fifth Avenue, Pittsburgh, PA 15213, USADepartment of Psychiatry, University of Pittsburgh, Thomas Detre Hall, 3811 O’Hara Street, Pittsburgh, PA 15213, USADepartment of Neurology, University of Pittsburgh, 811 Kaufmann Medical Building, 3471 Fifth Avenue, Pittsburgh, PA 15213, USADivision of General Internal Medicine and Geriatrics, Indiana University, Fifth Third Faculty Building, 720 Eskenazi Avenue, Indianapolis, IN 46202, USADepartment of Psychology, University of Pittsburgh, Sennott Square, 3rd Floor, 210 South Bouquet Street, Pittsburgh, PA 15260, USADepartment of Psychology, University of Pittsburgh, Sennott Square, 3rd Floor, 210 South Bouquet Street, Pittsburgh, PA 15260, USADepartment of Psychology, University of Pittsburgh, Sennott Square, 3rd Floor, 210 South Bouquet Street, Pittsburgh, PA 15260, USAIntroduction. A family history of Alzheimer’s disease is a significant risk factor for its onset, but the genetic risk associated with possessing multiple risk alleles is still poorly understood. Methods. In a sample of 95 older adults (Mean age = 75.1, 64.2% female), we constructed a genetic risk score based on the accumulation of risk alleles in BDNF, COMT, and APOE. A neuropsychological evaluation and consensus determined cognitive status (44 nonimpaired, 51 impaired). Logistic regression was performed to determine whether the genetic risk score predicted cognitive impairment above and beyond that associated with each gene. Results. An increased genetic risk score was associated with a nearly 4-fold increased risk of cognitive impairment (OR = 3.824, P = .013) when including the individual gene polymorphisms as covariates in the model. Discussion. A risk score combining multiple genetic influences may be more useful in predicting late-life cognitive impairment than individual polymorphisms.http://dx.doi.org/10.1155/2015/267062 |
| spellingShingle | Mariegold E. Wollam Andrea M. Weinstein Judith A. Saxton Lisa Morrow Beth Snitz Nicole R. Fowler Barbara L. Suever Erickson Kathryn A. Roecklein Kirk I. Erickson Genetic Risk Score Predicts Late-Life Cognitive Impairment Journal of Aging Research |
| title | Genetic Risk Score Predicts Late-Life Cognitive Impairment |
| title_full | Genetic Risk Score Predicts Late-Life Cognitive Impairment |
| title_fullStr | Genetic Risk Score Predicts Late-Life Cognitive Impairment |
| title_full_unstemmed | Genetic Risk Score Predicts Late-Life Cognitive Impairment |
| title_short | Genetic Risk Score Predicts Late-Life Cognitive Impairment |
| title_sort | genetic risk score predicts late life cognitive impairment |
| url | http://dx.doi.org/10.1155/2015/267062 |
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