Examining endothelial function and carotid artery disease in patients with inflammatory bowel disease: a systematic review protocol
Introduction Patients with inflammatory bowel disease (IBD) might be at an increased risk for the development of cardiovascular disease (CVD). The present protocol is developed to review and analyse published data to determine if patients with IBD have an increased CVD burden.Methods and analysis We...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e059785.full |
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| author | Hao Wu Zhenguo Liu Tingzi Hu Meihua Xu Hong Hao Michael A Hill Canxia Xu |
| author_facet | Hao Wu Zhenguo Liu Tingzi Hu Meihua Xu Hong Hao Michael A Hill Canxia Xu |
| author_sort | Hao Wu |
| collection | DOAJ |
| description | Introduction Patients with inflammatory bowel disease (IBD) might be at an increased risk for the development of cardiovascular disease (CVD). The present protocol is developed to review and analyse published data to determine if patients with IBD have an increased CVD burden.Methods and analysis We will conduct a systematic review of all observational studies that examine endothelial function, arterial stiffness and carotid intima-media thickness in patients with IBD. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and study quality will be assessed using the Newcastle-Ottawa Scale. If sufficient data are available, a meta-analysis will be conducted. The overall effect sizes will be estimated using both fixed effects models and random effects models. Statistical heterogeneity will be calculated using Higgin’s (I2) tests. Subgroup analyses, conditional number of studies retrieved and their sample size, will be stratified according to participant disease category or gender or disease activity.Ethics and dissemination Formal ethics approval is not required as individual data will not be collected. The results will be disseminated through peer-reviewed publications, conference presentations and scientific news releases.PROSPERO registration number CRD42021274093. |
| format | Article |
| id | doaj-art-6ffc8f54bb6a4c5981cdce9b99b60adf |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-6ffc8f54bb6a4c5981cdce9b99b60adf2025-01-27T14:30:15ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-059785Examining endothelial function and carotid artery disease in patients with inflammatory bowel disease: a systematic review protocolHao Wu0Zhenguo Liu1Tingzi Hu2Meihua Xu3Hong Hao4Michael A Hill5Canxia Xu6State Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China1 Department of Pharmacy, Northwest Women`s and Children`s Hospital, Xi`an, Shaanxi, ChinaSchool of Medicine, University of Missouri, Columbia, Missouri, USADepartment of Gastroenterology, Xiangya Hospital Central South University, Changsha, ChinaSchool of Medicine, University of Missouri, Columbia, Missouri, USADalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USADepartment of Gastroenterology, Central South University Third Xiangya Hospital, Changsha, ChinaIntroduction Patients with inflammatory bowel disease (IBD) might be at an increased risk for the development of cardiovascular disease (CVD). The present protocol is developed to review and analyse published data to determine if patients with IBD have an increased CVD burden.Methods and analysis We will conduct a systematic review of all observational studies that examine endothelial function, arterial stiffness and carotid intima-media thickness in patients with IBD. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and study quality will be assessed using the Newcastle-Ottawa Scale. If sufficient data are available, a meta-analysis will be conducted. The overall effect sizes will be estimated using both fixed effects models and random effects models. Statistical heterogeneity will be calculated using Higgin’s (I2) tests. Subgroup analyses, conditional number of studies retrieved and their sample size, will be stratified according to participant disease category or gender or disease activity.Ethics and dissemination Formal ethics approval is not required as individual data will not be collected. The results will be disseminated through peer-reviewed publications, conference presentations and scientific news releases.PROSPERO registration number CRD42021274093.https://bmjopen.bmj.com/content/12/6/e059785.full |
| spellingShingle | Hao Wu Zhenguo Liu Tingzi Hu Meihua Xu Hong Hao Michael A Hill Canxia Xu Examining endothelial function and carotid artery disease in patients with inflammatory bowel disease: a systematic review protocol BMJ Open |
| title | Examining endothelial function and carotid artery disease in patients with inflammatory bowel disease: a systematic review protocol |
| title_full | Examining endothelial function and carotid artery disease in patients with inflammatory bowel disease: a systematic review protocol |
| title_fullStr | Examining endothelial function and carotid artery disease in patients with inflammatory bowel disease: a systematic review protocol |
| title_full_unstemmed | Examining endothelial function and carotid artery disease in patients with inflammatory bowel disease: a systematic review protocol |
| title_short | Examining endothelial function and carotid artery disease in patients with inflammatory bowel disease: a systematic review protocol |
| title_sort | examining endothelial function and carotid artery disease in patients with inflammatory bowel disease a systematic review protocol |
| url | https://bmjopen.bmj.com/content/12/6/e059785.full |
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