The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State
Yellow fever (YF) is a zoonotic arthropod-borne disease that is caused by the yellow fever virus (YFV) and characterized by a sylvatic and urban cycle. Its most severe presentation is manifested as a hemorrhagic disease, and it has been responsible for thousands of deaths in the last decades. This s...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2019/9464768 |
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| author | Márcio Junio Lima Siconelli Danillo Lucas Alves Espósito Nathália Cristina Moraes Julia Maria Ribeiro Lívia Perles Maria Angélica Dias Adolorata Aparecida Bianco Carvalho Karin Werther Natália Coelho Couto de Azevedo Fernandes Silvia D'Andretta Iglezias Karina Paes Bürger Benedito Antonio Lopes da Fonseca |
| author_facet | Márcio Junio Lima Siconelli Danillo Lucas Alves Espósito Nathália Cristina Moraes Julia Maria Ribeiro Lívia Perles Maria Angélica Dias Adolorata Aparecida Bianco Carvalho Karin Werther Natália Coelho Couto de Azevedo Fernandes Silvia D'Andretta Iglezias Karina Paes Bürger Benedito Antonio Lopes da Fonseca |
| author_sort | Márcio Junio Lima Siconelli |
| collection | DOAJ |
| description | Yellow fever (YF) is a zoonotic arthropod-borne disease that is caused by the yellow fever virus (YFV) and characterized by a sylvatic and urban cycle. Its most severe presentation is manifested as a hemorrhagic disease, and it has been responsible for thousands of deaths in the last decades. This study describes the public health approaches taken to control the 2016-2017 YF outbreak in nonhuman primates (NHPs) that took place in the northeastern region of São Paulo state, Brazil. NHPs recovered from the field were necropsied, and YF diagnoses were made at the Laboratory of Molecular Virology, Ribeirão Preto Medical School and the Center of Pathology, Adolfo Lutz Institute of São Paulo. NHP samples were inoculated into Vero cells for YFV isolation. RNA extraction was performed directly from NHP tissues and tested by RT-qPCR. YFV-positive samples were confirmed by sequencing. Based on the rapid RT-qPCR results, surveillance actions were implemented in the entire region. Confirmatory histopathology and immunohistochemistry for YFV were also performed. Among nine NHPs, gross hepatic involvement was observed in six animals, five of which were YFV-RT-qPCR-positive. One YFV was isolated from the serum of an infant NHP. YFV RNA sequences diverged from the virus responsible for the last epizootic that occurred in São Paulo state, but it was similar to the current Brazilian epizootic. Public health actions included dissemination of information on YF transmission, investigation of the probable location of NHP infection, characterization of the environment, and subsequent creation of the blueprint from which prevention and control measures were implemented. The YFV sylvatic cycle occurred in the periurban areas of the northeastern region of São Paulo state, but no human cases were reported during this period, showing that integrated actions between human, animal, and environmental health professionals were critical to restrain the virus to the sylvatic cycle. |
| format | Article |
| id | doaj-art-6ff9905be1de4f869efdb035bfabc774 |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
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| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-6ff9905be1de4f869efdb035bfabc7742025-02-03T05:47:55ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932019-01-01201910.1155/2019/94647689464768The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo StateMárcio Junio Lima Siconelli0Danillo Lucas Alves Espósito1Nathália Cristina Moraes2Julia Maria Ribeiro3Lívia Perles4Maria Angélica Dias5Adolorata Aparecida Bianco Carvalho6Karin Werther7Natália Coelho Couto de Azevedo Fernandes8Silvia D'Andretta Iglezias9Karina Paes Bürger10Benedito Antonio Lopes da Fonseca11Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo FMRP/USP, Av. Bandeirantes, 3900, Vila Monte Alegre, Ribeirão Preto, 14049-900 São Paulo, BrazilDepartment of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo FMRP/USP, Av. Bandeirantes, 3900, Vila Monte Alegre, Ribeirão Preto, 14049-900 São Paulo, BrazilVeterinary Preventive Medicine and Animal Reproduction Department, Faculty of Agricultural and Veterinary Sciences, Universidade Estadual Paulista “Júlio de Mesquita Filho” (FCAV/Unesp), Access Way Prof. Paulo Donato Castellane s/n, Jaboticabal, 14884-900 São Paulo, BrazilAnimal Pathology Department, Faculty of Agricultural and Veterinary Sciences, Universidade Estadual Paulista “Júlio de Mesquita Filho” (FCAV/Unesp), Access Way Prof. Paulo Donato Castellane s/n, Jaboticabal, 14884-900 São Paulo, BrazilAnimal Pathology Department, Faculty of Agricultural and Veterinary Sciences, Universidade Estadual Paulista “Júlio de Mesquita Filho” (FCAV/Unesp), Access Way Prof. Paulo Donato Castellane s/n, Jaboticabal, 14884-900 São Paulo, BrazilMunicipal Health Secretary, Av. General Glicério, 569, Center, Jaboticabal, 14870-520 São Paulo, BrazilVeterinary Preventive Medicine and Animal Reproduction Department, Faculty of Agricultural and Veterinary Sciences, Universidade Estadual Paulista “Júlio de Mesquita Filho” (FCAV/Unesp), Access Way Prof. Paulo Donato Castellane s/n, Jaboticabal, 14884-900 São Paulo, BrazilAnimal Pathology Department, Faculty of Agricultural and Veterinary Sciences, Universidade Estadual Paulista “Júlio de Mesquita Filho” (FCAV/Unesp), Access Way Prof. Paulo Donato Castellane s/n, Jaboticabal, 14884-900 São Paulo, BrazilNucleus of Pathological Anatomy, Pathology Center, Adolfo Lutz Institute of São Paulo, State Secretary of Health, Av. Dr. Arnaldo, 351, 7° Floor, 01246-902 São Paulo, BrazilNucleus of Pathological Anatomy, Pathology Center, Adolfo Lutz Institute of São Paulo, State Secretary of Health, Av. Dr. Arnaldo, 351, 7° Floor, 01246-902 São Paulo, BrazilVeterinary Preventive Medicine and Animal Reproduction Department, Faculty of Agricultural and Veterinary Sciences, Universidade Estadual Paulista “Júlio de Mesquita Filho” (FCAV/Unesp), Access Way Prof. Paulo Donato Castellane s/n, Jaboticabal, 14884-900 São Paulo, BrazilDepartment of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo FMRP/USP, Av. Bandeirantes, 3900, Vila Monte Alegre, Ribeirão Preto, 14049-900 São Paulo, BrazilYellow fever (YF) is a zoonotic arthropod-borne disease that is caused by the yellow fever virus (YFV) and characterized by a sylvatic and urban cycle. Its most severe presentation is manifested as a hemorrhagic disease, and it has been responsible for thousands of deaths in the last decades. This study describes the public health approaches taken to control the 2016-2017 YF outbreak in nonhuman primates (NHPs) that took place in the northeastern region of São Paulo state, Brazil. NHPs recovered from the field were necropsied, and YF diagnoses were made at the Laboratory of Molecular Virology, Ribeirão Preto Medical School and the Center of Pathology, Adolfo Lutz Institute of São Paulo. NHP samples were inoculated into Vero cells for YFV isolation. RNA extraction was performed directly from NHP tissues and tested by RT-qPCR. YFV-positive samples were confirmed by sequencing. Based on the rapid RT-qPCR results, surveillance actions were implemented in the entire region. Confirmatory histopathology and immunohistochemistry for YFV were also performed. Among nine NHPs, gross hepatic involvement was observed in six animals, five of which were YFV-RT-qPCR-positive. One YFV was isolated from the serum of an infant NHP. YFV RNA sequences diverged from the virus responsible for the last epizootic that occurred in São Paulo state, but it was similar to the current Brazilian epizootic. Public health actions included dissemination of information on YF transmission, investigation of the probable location of NHP infection, characterization of the environment, and subsequent creation of the blueprint from which prevention and control measures were implemented. The YFV sylvatic cycle occurred in the periurban areas of the northeastern region of São Paulo state, but no human cases were reported during this period, showing that integrated actions between human, animal, and environmental health professionals were critical to restrain the virus to the sylvatic cycle.http://dx.doi.org/10.1155/2019/9464768 |
| spellingShingle | Márcio Junio Lima Siconelli Danillo Lucas Alves Espósito Nathália Cristina Moraes Julia Maria Ribeiro Lívia Perles Maria Angélica Dias Adolorata Aparecida Bianco Carvalho Karin Werther Natália Coelho Couto de Azevedo Fernandes Silvia D'Andretta Iglezias Karina Paes Bürger Benedito Antonio Lopes da Fonseca The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State |
| title_full | The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State |
| title_fullStr | The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State |
| title_full_unstemmed | The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State |
| title_short | The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State |
| title_sort | importance of coordinated actions in preventing the spread of yellow fever to human populations the experience from the 2016 2017 yellow fever outbreak in the northeastern region of sao paulo state |
| url | http://dx.doi.org/10.1155/2019/9464768 |
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