Effect of amniotic fluid on hair follicle growth
Purpose: Human amniotic fluid stem cells (hAFSCs) have shown significant regenerative potential in treating hair loss, wound healing, and tissue repair. This study aims to evaluate the effects of human amniotic fluid (hAF) on hair follicle (HF) regeneration and immune system modulation.Materials and...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2025.2451389 |
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| author | Gamze Tumentemur Elif Ganime Aygun Bulut Yurtsever Didem Cakirsoy Ercument Ovali |
| author_facet | Gamze Tumentemur Elif Ganime Aygun Bulut Yurtsever Didem Cakirsoy Ercument Ovali |
| author_sort | Gamze Tumentemur |
| collection | DOAJ |
| description | Purpose: Human amniotic fluid stem cells (hAFSCs) have shown significant regenerative potential in treating hair loss, wound healing, and tissue repair. This study aims to evaluate the effects of human amniotic fluid (hAF) on hair follicle (HF) regeneration and immune system modulation.Materials and Methods: The hAF used was pooled, acellular, and gamma-irradiated to standardize its contents and enhance its stability. Both irradiated (FAFI) and non-irradiated (FAF) hAF were assessed for their efficacy and safety in promoting hair growth and modulating immune responses in a rat model of hair loss. The study examined HF regeneration, transition to the anagen phase, and macrophage polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype.Results: Both FAF and FAFI treatments significantly increased HF density, with FAFI exhibiting enhanced effects. Histological analysis demonstrated improved HF regeneration, increased M2 macrophages, and reduced collagen fiber deposition in treated areas. Gamma irradiation likely improved the efficacy of FAFI by stabilizing active components and inhibiting protease activity.Conclusions: Irradiated hAF is a safe and effective therapeutic candidate for alopecia and HF growth disorders. These findings support further evaluation of hAF in clinical trials to validate its potential for hair regeneration therapies. |
| format | Article |
| id | doaj-art-6fedf7dee3e44143865355240353ca89 |
| institution | Kabale University |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-6fedf7dee3e44143865355240353ca892025-01-19T23:58:13ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532025-12-0136110.1080/09546634.2025.2451389Effect of amniotic fluid on hair follicle growthGamze Tumentemur0Elif Ganime Aygun1Bulut Yurtsever2Didem Cakirsoy3Ercument Ovali4Vocational School of Health Services, Acibadem Mehmet Ali Aydinlar University, Istanbul, TurkeyDepartment of Obstetrics and Gynecology, Acibadem Mehmet Ali Aydinlar University Atakent Hospital, Istanbul, TurkeyAcibadem Labcell Cellular Therapy Laboratory, Istanbul, TurkeyAcibadem Labcell Cellular Therapy Laboratory, Istanbul, TurkeyAcibadem Labcell Cellular Therapy Laboratory, Istanbul, TurkeyPurpose: Human amniotic fluid stem cells (hAFSCs) have shown significant regenerative potential in treating hair loss, wound healing, and tissue repair. This study aims to evaluate the effects of human amniotic fluid (hAF) on hair follicle (HF) regeneration and immune system modulation.Materials and Methods: The hAF used was pooled, acellular, and gamma-irradiated to standardize its contents and enhance its stability. Both irradiated (FAFI) and non-irradiated (FAF) hAF were assessed for their efficacy and safety in promoting hair growth and modulating immune responses in a rat model of hair loss. The study examined HF regeneration, transition to the anagen phase, and macrophage polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype.Results: Both FAF and FAFI treatments significantly increased HF density, with FAFI exhibiting enhanced effects. Histological analysis demonstrated improved HF regeneration, increased M2 macrophages, and reduced collagen fiber deposition in treated areas. Gamma irradiation likely improved the efficacy of FAFI by stabilizing active components and inhibiting protease activity.Conclusions: Irradiated hAF is a safe and effective therapeutic candidate for alopecia and HF growth disorders. These findings support further evaluation of hAF in clinical trials to validate its potential for hair regeneration therapies.https://www.tandfonline.com/doi/10.1080/09546634.2025.2451389Amniotic fluidfreezingpoolinggamma irradiationhair folliclemacrophage |
| spellingShingle | Gamze Tumentemur Elif Ganime Aygun Bulut Yurtsever Didem Cakirsoy Ercument Ovali Effect of amniotic fluid on hair follicle growth Journal of Dermatological Treatment Amniotic fluid freezing pooling gamma irradiation hair follicle macrophage |
| title | Effect of amniotic fluid on hair follicle growth |
| title_full | Effect of amniotic fluid on hair follicle growth |
| title_fullStr | Effect of amniotic fluid on hair follicle growth |
| title_full_unstemmed | Effect of amniotic fluid on hair follicle growth |
| title_short | Effect of amniotic fluid on hair follicle growth |
| title_sort | effect of amniotic fluid on hair follicle growth |
| topic | Amniotic fluid freezing pooling gamma irradiation hair follicle macrophage |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2025.2451389 |
| work_keys_str_mv | AT gamzetumentemur effectofamnioticfluidonhairfolliclegrowth AT elifganimeaygun effectofamnioticfluidonhairfolliclegrowth AT bulutyurtsever effectofamnioticfluidonhairfolliclegrowth AT didemcakirsoy effectofamnioticfluidonhairfolliclegrowth AT ercumentovali effectofamnioticfluidonhairfolliclegrowth |