Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs
The aim of the present study was to evaluate chitosan as a vaginal mucoadhesive gel base for econazole nitrate and miconazole nitrate. To this aim, different types of chitosan with different molecular masses and viscosity properties [low molecular mass chitosan (viscosity: 20,000 mPa s), medium mole...
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| Format: | Article |
| Language: | English |
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Sciendo
2014-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | http://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0013/acph-2014-0013.xml?format=INT |
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| author | Şenyiğit Zeynep Ay Karavana Sinem Yaprak Eraç Bayri Gürsel Özge Limoncu Mine Hoşgör Baloğlu Esra |
| author_facet | Şenyiğit Zeynep Ay Karavana Sinem Yaprak Eraç Bayri Gürsel Özge Limoncu Mine Hoşgör Baloğlu Esra |
| author_sort | Şenyiğit Zeynep Ay |
| collection | DOAJ |
| description | The aim of the present study was to evaluate chitosan as a vaginal mucoadhesive gel base for econazole nitrate and miconazole nitrate. To this aim, different types of chitosan with different molecular masses and viscosity properties [low molecular mass chitosan (viscosity: 20,000 mPa s), medium molecular mass chitosan (viscosity: 200,000 mPa s), high molecular mass chitosan (viscosity: 800,000 mPa s)] have been used. First, rheological studies were conducted on chitosan gels. Mechanical, syringeability and mucoadhesive properties of chitosan gels were determined. Release profiles of econazole nitrate and miconazole nitrate from chitosan gels were obtained and evaluated kinetically. In addition, anticandidal activities of formulations were determined. Finally, vaginal retention of chitosan gels in rats was evaluated by in vivo distribution studies. Based on the results, it can be concluded that gels prepared with medium molecular mass chitosan might be effectively used for different antifungal agents in the treatment of vaginal candidiosis, since it has high mucoadhesiveness, suitable mechanical and release properties with good vaginal retention |
| format | Article |
| id | doaj-art-6feb11ed0ca84b7a8a3f11b048849917 |
| institution | Kabale University |
| issn | 1330-0075 1846-9558 |
| language | English |
| publishDate | 2014-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-6feb11ed0ca84b7a8a3f11b0488499172025-02-02T22:25:39ZengSciendoActa Pharmaceutica1330-00751846-95582014-06-0164213915610.2478/acph-2014-0013acph-2014-0013Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugsŞenyiğit Zeynep Ay0Karavana Sinem Yaprak1Eraç Bayri2Gürsel Özge3Limoncu Mine Hoşgör4Baloğlu Esra5Ege University, Faculty of Pharmacy Department of Pharmaceutical Technology 35100 Bornova, İzmir, TurkeyEge University, Faculty of Pharmacy Department of Pharmaceutical Technology 35100 Bornova, İzmir, TurkeyEge University, Faculty of Pharmacy Department of Microbiology 35100 Bornova, İzmir, TurkeyEge University, Faculty of Pharmacy Department of Pharmaceutical Technology 35100 Bornova, İzmir, TurkeyEge University, Faculty of Pharmacy Department of Microbiology 35100 Bornova, İzmir, TurkeyEge University, Faculty of Pharmacy Department of Pharmaceutical Technology 35100 Bornova, İzmir, TurkeyThe aim of the present study was to evaluate chitosan as a vaginal mucoadhesive gel base for econazole nitrate and miconazole nitrate. To this aim, different types of chitosan with different molecular masses and viscosity properties [low molecular mass chitosan (viscosity: 20,000 mPa s), medium molecular mass chitosan (viscosity: 200,000 mPa s), high molecular mass chitosan (viscosity: 800,000 mPa s)] have been used. First, rheological studies were conducted on chitosan gels. Mechanical, syringeability and mucoadhesive properties of chitosan gels were determined. Release profiles of econazole nitrate and miconazole nitrate from chitosan gels were obtained and evaluated kinetically. In addition, anticandidal activities of formulations were determined. Finally, vaginal retention of chitosan gels in rats was evaluated by in vivo distribution studies. Based on the results, it can be concluded that gels prepared with medium molecular mass chitosan might be effectively used for different antifungal agents in the treatment of vaginal candidiosis, since it has high mucoadhesiveness, suitable mechanical and release properties with good vaginal retentionhttp://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0013/acph-2014-0013.xml?format=INTchitosanvaginal gelmucoadhesioneconazole nitratemiconazole nitratevaginal retention |
| spellingShingle | Şenyiğit Zeynep Ay Karavana Sinem Yaprak Eraç Bayri Gürsel Özge Limoncu Mine Hoşgör Baloğlu Esra Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs Acta Pharmaceutica chitosan vaginal gel mucoadhesion econazole nitrate miconazole nitrate vaginal retention |
| title | Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs |
| title_full | Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs |
| title_fullStr | Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs |
| title_full_unstemmed | Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs |
| title_short | Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs |
| title_sort | evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs |
| topic | chitosan vaginal gel mucoadhesion econazole nitrate miconazole nitrate vaginal retention |
| url | http://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0013/acph-2014-0013.xml?format=INT |
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