Molecular mechanisms of photosensitization induced by drugs XIV: Two different behaviours in the photochemistry and photosensitization of antibacterials containing a fluoroquinolone like chromophore
This paper deals with the photosensitizing activity of FLQs towards two different biosubstrates, membrane and DNA. The in vitro phototoxic activity of these drugs vs. DNA presents peculiar features with respect to that vs. membranes, probably due to a specific binding of the drugs to the double heli...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1999-01-01
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| Series: | International Journal of Photoenergy |
| Online Access: | http://dx.doi.org/10.1155/S1110662X99000033 |
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| author | G. De Guidi S. Giuffrida S. Monti P. S. Pisu S. Sortino L. L. Costanzo |
| author_facet | G. De Guidi S. Giuffrida S. Monti P. S. Pisu S. Sortino L. L. Costanzo |
| author_sort | G. De Guidi |
| collection | DOAJ |
| description | This paper deals with the photosensitizing activity of FLQs towards two different biosubstrates,
membrane and DNA. The in vitro phototoxic activity of these drugs vs. DNA presents peculiar features
with respect to that vs. membranes, probably due to a specific binding of the drugs to the double helix
and to the operativeness of different photosensitization mechanisms with the two types of biosubstrates.
A description of the UVA photochemistry and the photosensitizing properties of two significant examples
in the FLQ family is reported. The investigated compounds are Enoxacin, 1-ethyl-6-fluoro-1,4-dihydro-4-
oxo-7-[1-piperazinyl]-1,8-naphtyridine-3-carboxilic acid and Rufloxacin, 9-fluoro-2,3-dihydro-10-4´-methyl-
1´-piperazinyl-7-oxo-7H-pyrido[1,2,3−de]-1,4-benzothiazine-6-carboxylic acid. |
| format | Article |
| id | doaj-art-6fdd12fa166846ee8de6a09a32a62739 |
| institution | Kabale University |
| issn | 1110-662X |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Photoenergy |
| spelling | doaj-art-6fdd12fa166846ee8de6a09a32a627392025-02-03T01:32:01ZengWileyInternational Journal of Photoenergy1110-662X1999-01-0111131810.1155/S1110662X99000033Molecular mechanisms of photosensitization induced by drugs XIV: Two different behaviours in the photochemistry and photosensitization of antibacterials containing a fluoroquinolone like chromophoreG. De Guidi0S. Giuffrida1S. Monti2P. S. Pisu3S. Sortino4L. L. Costanzo5Dipartimento di Scienze Chimiche, Università di Catania, Viale A.Doria 8, Catania 95125, ItalyDipartimento di Scienze Chimiche, Università di Catania, Viale A.Doria 8, Catania 95125, ItalyIstituto di Fotochimica e Radiazioni d'Alta Energia del CNR, Area della Ricerca, Via P.Gobetti 101, Bologna 40129, ItalyDipartimento di Scienze Chimiche, Università di Catania, Viale A.Doria 8, Catania 95125, ItalyDipartimento di Scienze Chimiche, Università di Catania, Viale A.Doria 8, Catania 95125, ItalyDipartimento di Scienze Chimiche, Università di Catania, Viale A.Doria 8, Catania 95125, ItalyThis paper deals with the photosensitizing activity of FLQs towards two different biosubstrates, membrane and DNA. The in vitro phototoxic activity of these drugs vs. DNA presents peculiar features with respect to that vs. membranes, probably due to a specific binding of the drugs to the double helix and to the operativeness of different photosensitization mechanisms with the two types of biosubstrates. A description of the UVA photochemistry and the photosensitizing properties of two significant examples in the FLQ family is reported. The investigated compounds are Enoxacin, 1-ethyl-6-fluoro-1,4-dihydro-4- oxo-7-[1-piperazinyl]-1,8-naphtyridine-3-carboxilic acid and Rufloxacin, 9-fluoro-2,3-dihydro-10-4´-methyl- 1´-piperazinyl-7-oxo-7H-pyrido[1,2,3−de]-1,4-benzothiazine-6-carboxylic acid.http://dx.doi.org/10.1155/S1110662X99000033 |
| spellingShingle | G. De Guidi S. Giuffrida S. Monti P. S. Pisu S. Sortino L. L. Costanzo Molecular mechanisms of photosensitization induced by drugs XIV: Two different behaviours in the photochemistry and photosensitization of antibacterials containing a fluoroquinolone like chromophore International Journal of Photoenergy |
| title | Molecular mechanisms of photosensitization induced by drugs XIV: Two different behaviours in the photochemistry and photosensitization of antibacterials containing a fluoroquinolone like chromophore |
| title_full | Molecular mechanisms of photosensitization induced by drugs XIV: Two different behaviours in the photochemistry and photosensitization of antibacterials containing a fluoroquinolone like chromophore |
| title_fullStr | Molecular mechanisms of photosensitization induced by drugs XIV: Two different behaviours in the photochemistry and photosensitization of antibacterials containing a fluoroquinolone like chromophore |
| title_full_unstemmed | Molecular mechanisms of photosensitization induced by drugs XIV: Two different behaviours in the photochemistry and photosensitization of antibacterials containing a fluoroquinolone like chromophore |
| title_short | Molecular mechanisms of photosensitization induced by drugs XIV: Two different behaviours in the photochemistry and photosensitization of antibacterials containing a fluoroquinolone like chromophore |
| title_sort | molecular mechanisms of photosensitization induced by drugs xiv two different behaviours in the photochemistry and photosensitization of antibacterials containing a fluoroquinolone like chromophore |
| url | http://dx.doi.org/10.1155/S1110662X99000033 |
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