Increasing survival time decreases the cost-effectiveness of using "test & treat to eliminate HIV epidemics
Treating HIV-infected individuals reduces their viral load, consequently increasing their survival time and decreasing their infectivity.It has been proposed that universal testing and treatment (i.e., universal ``test & treat'') could lead to HIV elimination and would be extremely...
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| Format: | Article |
| Language: | English |
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AIMS Press
2013-07-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.1673 |
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| author | Bradley G. Wagner Brian J. Coburn Sally Blower |
| author_facet | Bradley G. Wagner Brian J. Coburn Sally Blower |
| author_sort | Bradley G. Wagner |
| collection | DOAJ |
| description | Treating HIV-infected individuals reduces their viral load, consequently increasing their survival time and decreasing their infectivity.It has been proposed that universal testing and treatment (i.e., universal ``test & treat'') could lead to HIV elimination and would be extremely cost-effective.It is now being debated whether to use a universal ``test and treat'' approach in the ``real-world'' as a prevention strategy to control HIV epidemics.However current modeling predictions of the impact, and cost-effectiveness, of universal ``test & treat'' strategies are based on an unrealistically short survival time for treated individuals.Here we use mathematical modeling and a longer, more realistic, survival time.We model the potential impact of a universal ``test & treat'' strategy in South Africa.Our results show that increasing the length of the survival time on treatment, although beneficial to individuals, reduces the probability of eliminating HIV and decreases the cost-effectiveness of using universal ``test & treat'' strategies.Therefore our results show that individual-level benefits and public health benefits will conflict when using ``test & treat'' strategies to reduce HIV transmission. |
| format | Article |
| id | doaj-art-6fd916a95b4547cc98359c50c33e60b3 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2013-07-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-6fd916a95b4547cc98359c50c33e60b32025-01-24T02:26:34ZengAIMS PressMathematical Biosciences and Engineering1551-00182013-07-01105&61673168610.3934/mbe.2013.10.1673Increasing survival time decreases the cost-effectiveness of using "test & treat to eliminate HIV epidemicsBradley G. Wagner0Brian J. Coburn1Sally Blower2Center for Biomedical Modeling, Semel Institute of Neuroscience & Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, 10940 Wilshire Blvd, Suite 1450, Los Angeles, CA 90024Center for Biomedical Modeling, Semel Institute of Neuroscience & Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, 10940 Wilshire Blvd, Suite 1450, Los Angeles, CA 90024Center for Biomedical Modeling, Semel Institute of Neuroscience & Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, 10940 Wilshire Blvd, Suite 1450, Los Angeles, CA 90024Treating HIV-infected individuals reduces their viral load, consequently increasing their survival time and decreasing their infectivity.It has been proposed that universal testing and treatment (i.e., universal ``test & treat'') could lead to HIV elimination and would be extremely cost-effective.It is now being debated whether to use a universal ``test and treat'' approach in the ``real-world'' as a prevention strategy to control HIV epidemics.However current modeling predictions of the impact, and cost-effectiveness, of universal ``test & treat'' strategies are based on an unrealistically short survival time for treated individuals.Here we use mathematical modeling and a longer, more realistic, survival time.We model the potential impact of a universal ``test & treat'' strategy in South Africa.Our results show that increasing the length of the survival time on treatment, although beneficial to individuals, reduces the probability of eliminating HIV and decreases the cost-effectiveness of using universal ``test & treat'' strategies.Therefore our results show that individual-level benefits and public health benefits will conflict when using ``test & treat'' strategies to reduce HIV transmission.https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.1673cost-effectiveness.hiv epidemicstransmission model |
| spellingShingle | Bradley G. Wagner Brian J. Coburn Sally Blower Increasing survival time decreases the cost-effectiveness of using "test & treat to eliminate HIV epidemics Mathematical Biosciences and Engineering cost-effectiveness. hiv epidemics transmission model |
| title | Increasing survival time decreases the cost-effectiveness of using "test & treat to eliminate HIV epidemics |
| title_full | Increasing survival time decreases the cost-effectiveness of using "test & treat to eliminate HIV epidemics |
| title_fullStr | Increasing survival time decreases the cost-effectiveness of using "test & treat to eliminate HIV epidemics |
| title_full_unstemmed | Increasing survival time decreases the cost-effectiveness of using "test & treat to eliminate HIV epidemics |
| title_short | Increasing survival time decreases the cost-effectiveness of using "test & treat to eliminate HIV epidemics |
| title_sort | increasing survival time decreases the cost effectiveness of using quot test amp treat to eliminate hiv epidemics |
| topic | cost-effectiveness. hiv epidemics transmission model |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.1673 |
| work_keys_str_mv | AT bradleygwagner increasingsurvivaltimedecreasesthecosteffectivenessofusingquottestamptreattoeliminatehivepidemics AT brianjcoburn increasingsurvivaltimedecreasesthecosteffectivenessofusingquottestamptreattoeliminatehivepidemics AT sallyblower increasingsurvivaltimedecreasesthecosteffectivenessofusingquottestamptreattoeliminatehivepidemics |