Investigation of Galectin-3 and Cardiotrophin-1 Concentrations as Biomarkers in Dogs with Neurological Distemper
Canine distemper, caused by <i>Morbillivirus canis</i>, is a highly morbid and lethal disease characterized by multiple systemic and neurological signs. In recent years, biomarkers, such as Galectin-3 and Cardiotrophin-1, have been investigated in inflammatory and degenerative diseases....
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MDPI AG
2025-05-01
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| author | Alper Erturk Aliye Sagkan Ozturk Atakan Ozturk |
| author_facet | Alper Erturk Aliye Sagkan Ozturk Atakan Ozturk |
| author_sort | Alper Erturk |
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| description | Canine distemper, caused by <i>Morbillivirus canis</i>, is a highly morbid and lethal disease characterized by multiple systemic and neurological signs. In recent years, biomarkers, such as Galectin-3 and Cardiotrophin-1, have been investigated in inflammatory and degenerative diseases. However, the role of these biomarkers in neurological distemper has not been investigated. The aim of this study is to compare blood serum Galectin-3 and Cardiotrophin-1 concentrations between the neurological distemper and control group, and to evaluate the correlations of these biomarkers with hematobiochemical parameters in dogs with neurological distemper. Nineteen owned dogs (13 diagnosed with neurological distemper and 6 controls) were included in the study. Hematobiochemical analyses were performed in all dogs, and Galectin-3 and Cardiotrophin-1 concentrations were measured using ELISA. Serum concentrations of Galectin-3 and Cardiotrophin-1 were markedly elevated in dogs with neurological distemper compared to the control group (<i>p</i> < 0.05). A negative correlation between Galectin-3 and monocytes (<i>p</i> < 0.05) and a positive correlation between Galectin-3 and platelet and platelecrit levels (<i>p</i> < 0.05) were observed. There was negative correlation with Cardiotrophin-1 and lymphocyte percentage (<i>p</i> < 0.01) and a positive correlation with Cardiotrophin-1 and granulocyte percentage (<i>p</i> < 0.01). Galectin-3 and Cardiotrophin-1 may serve as biomarkers for the diagnosis and understanding of neurological distemper pathogenesis. Elevated serum concentrations of these biomarkers may indicate underlying neuroinflammation. This may contribute to the pathogenesis of neurological distemper. |
| format | Article |
| id | doaj-art-6fd2c03faeeb49a3a5fb9cc0f736d50a |
| institution | DOAJ |
| issn | 2306-7381 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Veterinary Sciences |
| spelling | doaj-art-6fd2c03faeeb49a3a5fb9cc0f736d50a2025-08-20T03:12:07ZengMDPI AGVeterinary Sciences2306-73812025-05-0112549910.3390/vetsci12050499Investigation of Galectin-3 and Cardiotrophin-1 Concentrations as Biomarkers in Dogs with Neurological DistemperAlper Erturk0Aliye Sagkan Ozturk1Atakan Ozturk2Department of Internal Medicine, Veterinary Faculty, Hatay Mustafa Kemal University, Antakya 31040, Hatay, TürkiyeDepartment of Internal Medicine, Veterinary Faculty, Hatay Mustafa Kemal University, Antakya 31040, Hatay, TürkiyeDepartment of Physiology, Medicine Faculty, Gaziantep Islam Science and Technology University, Gaziantep 27010, Gaziantep, TürkiyeCanine distemper, caused by <i>Morbillivirus canis</i>, is a highly morbid and lethal disease characterized by multiple systemic and neurological signs. In recent years, biomarkers, such as Galectin-3 and Cardiotrophin-1, have been investigated in inflammatory and degenerative diseases. However, the role of these biomarkers in neurological distemper has not been investigated. The aim of this study is to compare blood serum Galectin-3 and Cardiotrophin-1 concentrations between the neurological distemper and control group, and to evaluate the correlations of these biomarkers with hematobiochemical parameters in dogs with neurological distemper. Nineteen owned dogs (13 diagnosed with neurological distemper and 6 controls) were included in the study. Hematobiochemical analyses were performed in all dogs, and Galectin-3 and Cardiotrophin-1 concentrations were measured using ELISA. Serum concentrations of Galectin-3 and Cardiotrophin-1 were markedly elevated in dogs with neurological distemper compared to the control group (<i>p</i> < 0.05). A negative correlation between Galectin-3 and monocytes (<i>p</i> < 0.05) and a positive correlation between Galectin-3 and platelet and platelecrit levels (<i>p</i> < 0.05) were observed. There was negative correlation with Cardiotrophin-1 and lymphocyte percentage (<i>p</i> < 0.01) and a positive correlation with Cardiotrophin-1 and granulocyte percentage (<i>p</i> < 0.01). Galectin-3 and Cardiotrophin-1 may serve as biomarkers for the diagnosis and understanding of neurological distemper pathogenesis. Elevated serum concentrations of these biomarkers may indicate underlying neuroinflammation. This may contribute to the pathogenesis of neurological distemper.https://www.mdpi.com/2306-7381/12/5/499canine distemper virusgalectin-3cardiotrophin-1neurological distemperbiomarkers |
| spellingShingle | Alper Erturk Aliye Sagkan Ozturk Atakan Ozturk Investigation of Galectin-3 and Cardiotrophin-1 Concentrations as Biomarkers in Dogs with Neurological Distemper Veterinary Sciences canine distemper virus galectin-3 cardiotrophin-1 neurological distemper biomarkers |
| title | Investigation of Galectin-3 and Cardiotrophin-1 Concentrations as Biomarkers in Dogs with Neurological Distemper |
| title_full | Investigation of Galectin-3 and Cardiotrophin-1 Concentrations as Biomarkers in Dogs with Neurological Distemper |
| title_fullStr | Investigation of Galectin-3 and Cardiotrophin-1 Concentrations as Biomarkers in Dogs with Neurological Distemper |
| title_full_unstemmed | Investigation of Galectin-3 and Cardiotrophin-1 Concentrations as Biomarkers in Dogs with Neurological Distemper |
| title_short | Investigation of Galectin-3 and Cardiotrophin-1 Concentrations as Biomarkers in Dogs with Neurological Distemper |
| title_sort | investigation of galectin 3 and cardiotrophin 1 concentrations as biomarkers in dogs with neurological distemper |
| topic | canine distemper virus galectin-3 cardiotrophin-1 neurological distemper biomarkers |
| url | https://www.mdpi.com/2306-7381/12/5/499 |
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