Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas

Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas

Abstract Background The insulin-like growth factor 2 (IGF2) is overexpressed in 90% of adrenocortical carcinomas (ACC) and promotes cell proliferation via IGF1R and isoform A of insulin receptor (IRA). However, IGF2 role in ACC tumourigenesis has not been completely understood yet, and the contribut...

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Main Authors: Rosa Catalano, Emma Nozza, Barbara Altieri, Emanuela Esposito, Giorgio A. Croci, Anna Maria Barbieri, Donatella Treppiedi, Sonia Di Bari, Otilia Kimpel, Mario Detomas, Mariangela Tamburello, Marc P. Schauer, Sabine Herterich, Anna Angelousi, Michaela Luconi, Letizia Canu, Gabriella Nesi, Constanze Hantel, Sandra Sigala, Laura-Sophie Landwehr, Guido Di Dalmazi, Elisa Cassinotti, Ludovica Baldari, Serena Palmieri, Alessandra Mangone, Emanuele Ferrante, Cristina L. Ronchi, Giovanna Mantovani, Erika Peverelli
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cell Communication and Signaling
Subjects:
Adrenocortical carcinoma
IGF1R
Insulin receptor
Biomarker
Cellular localisation
Online Access:https://doi.org/10.1186/s12964-025-02115-0
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