Isotretinoin-Induced Delusional Disorder, Somatic Subtype

Isotretinoin, an active form of vitamin A, is the drug of last resort for the treatment of severe acne. Depression, suicidal ideation, and psychosis are among the most well-documented psychiatric side effects. Here, we report a case of isotretinoin-induced psychosis, which was diagnosed as delusiona...

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Main Authors: Katharine V. Jensen, Adam Abba-Aji
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Case Reports in Dermatological Medicine
Online Access:http://dx.doi.org/10.1155/2020/8853167
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author Katharine V. Jensen
Adam Abba-Aji
author_facet Katharine V. Jensen
Adam Abba-Aji
author_sort Katharine V. Jensen
collection DOAJ
description Isotretinoin, an active form of vitamin A, is the drug of last resort for the treatment of severe acne. Depression, suicidal ideation, and psychosis are among the most well-documented psychiatric side effects. Here, we report a case of isotretinoin-induced psychosis, which was diagnosed as delusional disorder somatic subtype, in a young male in the absence of any prodromal symptoms, previous psychiatric history, or family history of mental illness. The onset of psychosis was in the context of a dosage increase from 40 mg/day to 80 mg/day. Isotretinoin was discontinued, and the patient showed improvement on low-dose quetiapine.
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institution Kabale University
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series Case Reports in Dermatological Medicine
spelling doaj-art-6fc204c7f7614a3d8a8853a073210d332025-02-03T06:46:35ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712020-01-01202010.1155/2020/88531678853167Isotretinoin-Induced Delusional Disorder, Somatic SubtypeKatharine V. Jensen0Adam Abba-Aji1Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, CanadaDepartment of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, CanadaIsotretinoin, an active form of vitamin A, is the drug of last resort for the treatment of severe acne. Depression, suicidal ideation, and psychosis are among the most well-documented psychiatric side effects. Here, we report a case of isotretinoin-induced psychosis, which was diagnosed as delusional disorder somatic subtype, in a young male in the absence of any prodromal symptoms, previous psychiatric history, or family history of mental illness. The onset of psychosis was in the context of a dosage increase from 40 mg/day to 80 mg/day. Isotretinoin was discontinued, and the patient showed improvement on low-dose quetiapine.http://dx.doi.org/10.1155/2020/8853167
spellingShingle Katharine V. Jensen
Adam Abba-Aji
Isotretinoin-Induced Delusional Disorder, Somatic Subtype
Case Reports in Dermatological Medicine
title Isotretinoin-Induced Delusional Disorder, Somatic Subtype
title_full Isotretinoin-Induced Delusional Disorder, Somatic Subtype
title_fullStr Isotretinoin-Induced Delusional Disorder, Somatic Subtype
title_full_unstemmed Isotretinoin-Induced Delusional Disorder, Somatic Subtype
title_short Isotretinoin-Induced Delusional Disorder, Somatic Subtype
title_sort isotretinoin induced delusional disorder somatic subtype
url http://dx.doi.org/10.1155/2020/8853167
work_keys_str_mv AT katharinevjensen isotretinoininduceddelusionaldisordersomaticsubtype
AT adamabbaaji isotretinoininduceddelusionaldisordersomaticsubtype