Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish

Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish

Abstract The liver’s regenerative ability depends on injury extent. Minor injuries are repaired by hepatocyte self-duplication, while severe damage triggers cholangiocyte involvement in hepatocyte recovery. This paradigm is well-documented for adult animals but is less explored during rapid growth....

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Main Authors: Sema Elif Eski, Jiarui Mi, Macarena Pozo-Morales, Gabriel Garnik Hovhannisyan, Camille Perazzolo, Rita Manco, Imane Ez-Zammoury, Dev Barbhaya, Anne Lefort, Frédérick Libert, Federico Marini, Esteban N. Gurzov, Olov Andersson, Sumeet Pal Singh
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60334-y
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https://doi.org/10.1038/s41467-025-60334-y

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