Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives
Four new 1,2,3-triazole phthalimide derivatives with a potent anti-inflammatory activity have been synthesized in the good yields by the 1,3-dipolar cycloaddition reaction from N-(azido-alkyl)phthalimides and terminal alkynes. The anti-inflammatory activity was determined by injecting carrageenan th...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/925925 |
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| author | Shalom Pôrto de Oliveira Assis Moara Targino da Silva Ronaldo Nascimento de Oliveira Vera Lúcia de Menezes Lima |
| author_facet | Shalom Pôrto de Oliveira Assis Moara Targino da Silva Ronaldo Nascimento de Oliveira Vera Lúcia de Menezes Lima |
| author_sort | Shalom Pôrto de Oliveira Assis |
| collection | DOAJ |
| description | Four new 1,2,3-triazole phthalimide derivatives with a potent anti-inflammatory activity have been synthesized in the good yields by the 1,3-dipolar cycloaddition reaction from N-(azido-alkyl)phthalimides and terminal alkynes. The anti-inflammatory activity was determined by injecting carrageenan through the plantar tissue of the right hind paw of Swiss white mice to produce inflammation. All the compounds 3a–c and 5a–c exhibited an important anti-inflammatory activity; the best activity was found for the compounds 3b and 5c, which showed to be able to decrease by 69% and 56.2% carrageenan-induced edema in mice. These compounds may also offer a future promise as a new anti-inflammatory agent. |
| format | Article |
| id | doaj-art-6fbcbe160a894f7dbf4787d8d6860478 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-6fbcbe160a894f7dbf4787d8d68604782025-02-03T05:50:16ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/925925925925Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole DerivativesShalom Pôrto de Oliveira Assis0Moara Targino da Silva1Ronaldo Nascimento de Oliveira2Vera Lúcia de Menezes Lima3Laboratório de Química e Metabolismo de Lipídeos e Lipoproteínas, Departamento de Bioquímica, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego s/n, 50670-420 Recife, PE, BrazilLaboratório de Síntese de Compostos Bioativos (LSCB), Departamento de Ciências Moleculares, Universidade Federal Rural de Pernambuco (UFRPE), Rua Dom Manoel de Medeiros s/n, Dois Irmãos, 52171-900 Recife, PE, BrazilLaboratório de Síntese de Compostos Bioativos (LSCB), Departamento de Ciências Moleculares, Universidade Federal Rural de Pernambuco (UFRPE), Rua Dom Manoel de Medeiros s/n, Dois Irmãos, 52171-900 Recife, PE, BrazilLaboratório de Química e Metabolismo de Lipídeos e Lipoproteínas, Departamento de Bioquímica, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego s/n, 50670-420 Recife, PE, BrazilFour new 1,2,3-triazole phthalimide derivatives with a potent anti-inflammatory activity have been synthesized in the good yields by the 1,3-dipolar cycloaddition reaction from N-(azido-alkyl)phthalimides and terminal alkynes. The anti-inflammatory activity was determined by injecting carrageenan through the plantar tissue of the right hind paw of Swiss white mice to produce inflammation. All the compounds 3a–c and 5a–c exhibited an important anti-inflammatory activity; the best activity was found for the compounds 3b and 5c, which showed to be able to decrease by 69% and 56.2% carrageenan-induced edema in mice. These compounds may also offer a future promise as a new anti-inflammatory agent.http://dx.doi.org/10.1100/2012/925925 |
| spellingShingle | Shalom Pôrto de Oliveira Assis Moara Targino da Silva Ronaldo Nascimento de Oliveira Vera Lúcia de Menezes Lima Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives The Scientific World Journal |
| title | Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives |
| title_full | Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives |
| title_fullStr | Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives |
| title_full_unstemmed | Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives |
| title_short | Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives |
| title_sort | synthesis and anti inflammatory activity of new alkyl substituted phthalimide 1h 1 2 3 triazole derivatives |
| url | http://dx.doi.org/10.1100/2012/925925 |
| work_keys_str_mv | AT shalomportodeoliveiraassis synthesisandantiinflammatoryactivityofnewalkylsubstitutedphthalimide1h123triazolederivatives AT moaratarginodasilva synthesisandantiinflammatoryactivityofnewalkylsubstitutedphthalimide1h123triazolederivatives AT ronaldonascimentodeoliveira synthesisandantiinflammatoryactivityofnewalkylsubstitutedphthalimide1h123triazolederivatives AT veraluciademenezeslima synthesisandantiinflammatoryactivityofnewalkylsubstitutedphthalimide1h123triazolederivatives |