Reactivation of Pulmonary Tuberculosis following Treatment of Myelofibrosis with Ruxolitinib
Ruxolitinib is widely in use for treatment of myeloproliferative disorders. It causes inhibition of the Janus kinase (JAK) signal transducer and activation of transcription (STAT) pathway, which plays a key role in the underlying pathophysiology of myeloproliferative diseases. We describe a case of...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2016/2389038 |
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| author | Maheen Z. Abidi Javeria Haque Parvathi Varma Horatiu Olteanu Guru Subramanian Guru Murthy Binod Dhakal Parameswaran Hari |
| author_facet | Maheen Z. Abidi Javeria Haque Parvathi Varma Horatiu Olteanu Guru Subramanian Guru Murthy Binod Dhakal Parameswaran Hari |
| author_sort | Maheen Z. Abidi |
| collection | DOAJ |
| description | Ruxolitinib is widely in use for treatment of myeloproliferative disorders. It causes inhibition of the Janus kinase (JAK) signal transducer and activation of transcription (STAT) pathway, which plays a key role in the underlying pathophysiology of myeloproliferative diseases. We describe a case of reactivation pulmonary tuberculosis in a retired physician while on treatment with ruxolitinib. We also review the literature on opportunistic infections following use of ruxolitinib. Our case highlights the importance of screening for latent tuberculosis in patients from highly endemic areas prior to start of therapy with ruxolitinib. |
| format | Article |
| id | doaj-art-6fb9c122b64943bc99d3321fc7447a57 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-6fb9c122b64943bc99d3321fc7447a572025-02-03T01:22:28ZengWileyCase Reports in Hematology2090-65602090-65792016-01-01201610.1155/2016/23890382389038Reactivation of Pulmonary Tuberculosis following Treatment of Myelofibrosis with RuxolitinibMaheen Z. Abidi0Javeria Haque1Parvathi Varma2Horatiu Olteanu3Guru Subramanian Guru Murthy4Binod Dhakal5Parameswaran Hari6Division of Infectious Diseases, Department of Medicine, University of Colorado, Denver, CO, USADivision of Infectious Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USAUniversity of Birmingham Medical School, Edgbaston, Birmingham, UKDepartment of Pathology, Medical College of Wisconsin, Milwaukee, WI, USADivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USADivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USADivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USARuxolitinib is widely in use for treatment of myeloproliferative disorders. It causes inhibition of the Janus kinase (JAK) signal transducer and activation of transcription (STAT) pathway, which plays a key role in the underlying pathophysiology of myeloproliferative diseases. We describe a case of reactivation pulmonary tuberculosis in a retired physician while on treatment with ruxolitinib. We also review the literature on opportunistic infections following use of ruxolitinib. Our case highlights the importance of screening for latent tuberculosis in patients from highly endemic areas prior to start of therapy with ruxolitinib.http://dx.doi.org/10.1155/2016/2389038 |
| spellingShingle | Maheen Z. Abidi Javeria Haque Parvathi Varma Horatiu Olteanu Guru Subramanian Guru Murthy Binod Dhakal Parameswaran Hari Reactivation of Pulmonary Tuberculosis following Treatment of Myelofibrosis with Ruxolitinib Case Reports in Hematology |
| title | Reactivation of Pulmonary Tuberculosis following Treatment of Myelofibrosis with Ruxolitinib |
| title_full | Reactivation of Pulmonary Tuberculosis following Treatment of Myelofibrosis with Ruxolitinib |
| title_fullStr | Reactivation of Pulmonary Tuberculosis following Treatment of Myelofibrosis with Ruxolitinib |
| title_full_unstemmed | Reactivation of Pulmonary Tuberculosis following Treatment of Myelofibrosis with Ruxolitinib |
| title_short | Reactivation of Pulmonary Tuberculosis following Treatment of Myelofibrosis with Ruxolitinib |
| title_sort | reactivation of pulmonary tuberculosis following treatment of myelofibrosis with ruxolitinib |
| url | http://dx.doi.org/10.1155/2016/2389038 |
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