The association between oxidative balance score with constipation and diarrhea in US adults: a cross-sectional analysis of NHANES 2007–2010
Abstract Background Oxidative stress is associated with functional bowel disorders. The Oxidative Balance Score (OBS) is used to represent the overall level of oxidative stress experienced by an individual. Sex differences are exhibited in the occurrence of constipation and diarrhea. This population...
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2025-01-01
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| author | Yaoling Cao Zhihao Yang Qinqing Tang |
| author_facet | Yaoling Cao Zhihao Yang Qinqing Tang |
| author_sort | Yaoling Cao |
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| description | Abstract Background Oxidative stress is associated with functional bowel disorders. The Oxidative Balance Score (OBS) is used to represent the overall level of oxidative stress experienced by an individual. Sex differences are exhibited in the occurrence of constipation and diarrhea. This population-based study aimed to examine the association between the OBS, constipation, and diarrhea, among adults in the United States (US), stratified by sex. Methods Using data from the National Health and Nutrition Examination Survey (NHANES) database spanning from 2007 to 2010, a cross-sectional study including 4,462 participants (2,386 males and 2,076 females) was performed to assess the relationship between the OBS, constipation, and diarrhea, among adult men and women in the US. Constipation and diarrhea were identified according to bowel frequency and stool type, as outlined in the Bowel Health Questionnaire. The independent variable was the OBS based on 20 types of dietary and lifestyle components. We conducted a binary logistic regression subgroup analysis by sex, and a univariate subgroup analysis; and used a restricted cubic spline (RCS) to illustrate the relationship between the OBS and abnormal bowel health. Results After adjusting for all covariates, a multivariate binary logistic regression analysis revealed that the OBS was negatively correlated with constipation in males [odds ratios (OR) (95% confidence intervals (CI)): 0.937 (0.888, 0.988), P = 0.017], and diarrhea in females [OR (95%CI): 0.951 (0.916, 0.987), P = 0.009]. RCS analysis identified a negative linear trend between OBS and constipation in males (P for non-linearity = 0.63), as well as between OBS and diarrhea in females (P for non-linearity > 0.05). Conclusion The current study found a negative correlation between the OBS and the risk of constipation in males, along with diarrhea in females. Oxidative stress, gut microbiota, and sex differences may be associated with intestinal dysfunction. These findings suggest that antioxidant-rich dietary modifications may be an effective strategy for preventing constipation in males and diarrhea in females. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| series | BMC Gastroenterology |
| spelling | doaj-art-6fb9bfad862548ba827b179e25a3891d2025-01-26T12:36:19ZengBMCBMC Gastroenterology1471-230X2025-01-0125111710.1186/s12876-025-03597-5The association between oxidative balance score with constipation and diarrhea in US adults: a cross-sectional analysis of NHANES 2007–2010Yaoling Cao0Zhihao Yang1Qinqing Tang2Department of General Medicine, the First Affiliated Hospital of Anhui Medical UniversityDepartment of General Surgery, the First Affiliated Hospital of Anhui Medical UniversityDepartment of General Surgery, the First Affiliated Hospital of Anhui Medical UniversityAbstract Background Oxidative stress is associated with functional bowel disorders. The Oxidative Balance Score (OBS) is used to represent the overall level of oxidative stress experienced by an individual. Sex differences are exhibited in the occurrence of constipation and diarrhea. This population-based study aimed to examine the association between the OBS, constipation, and diarrhea, among adults in the United States (US), stratified by sex. Methods Using data from the National Health and Nutrition Examination Survey (NHANES) database spanning from 2007 to 2010, a cross-sectional study including 4,462 participants (2,386 males and 2,076 females) was performed to assess the relationship between the OBS, constipation, and diarrhea, among adult men and women in the US. Constipation and diarrhea were identified according to bowel frequency and stool type, as outlined in the Bowel Health Questionnaire. The independent variable was the OBS based on 20 types of dietary and lifestyle components. We conducted a binary logistic regression subgroup analysis by sex, and a univariate subgroup analysis; and used a restricted cubic spline (RCS) to illustrate the relationship between the OBS and abnormal bowel health. Results After adjusting for all covariates, a multivariate binary logistic regression analysis revealed that the OBS was negatively correlated with constipation in males [odds ratios (OR) (95% confidence intervals (CI)): 0.937 (0.888, 0.988), P = 0.017], and diarrhea in females [OR (95%CI): 0.951 (0.916, 0.987), P = 0.009]. RCS analysis identified a negative linear trend between OBS and constipation in males (P for non-linearity = 0.63), as well as between OBS and diarrhea in females (P for non-linearity > 0.05). Conclusion The current study found a negative correlation between the OBS and the risk of constipation in males, along with diarrhea in females. Oxidative stress, gut microbiota, and sex differences may be associated with intestinal dysfunction. These findings suggest that antioxidant-rich dietary modifications may be an effective strategy for preventing constipation in males and diarrhea in females.https://doi.org/10.1186/s12876-025-03597-5ConstipationDiarrheaCross-sectional studyOxidative balance scoreNHANES |
| spellingShingle | Yaoling Cao Zhihao Yang Qinqing Tang The association between oxidative balance score with constipation and diarrhea in US adults: a cross-sectional analysis of NHANES 2007–2010 BMC Gastroenterology Constipation Diarrhea Cross-sectional study Oxidative balance score NHANES |
| title | The association between oxidative balance score with constipation and diarrhea in US adults: a cross-sectional analysis of NHANES 2007–2010 |
| title_full | The association between oxidative balance score with constipation and diarrhea in US adults: a cross-sectional analysis of NHANES 2007–2010 |
| title_fullStr | The association between oxidative balance score with constipation and diarrhea in US adults: a cross-sectional analysis of NHANES 2007–2010 |
| title_full_unstemmed | The association between oxidative balance score with constipation and diarrhea in US adults: a cross-sectional analysis of NHANES 2007–2010 |
| title_short | The association between oxidative balance score with constipation and diarrhea in US adults: a cross-sectional analysis of NHANES 2007–2010 |
| title_sort | association between oxidative balance score with constipation and diarrhea in us adults a cross sectional analysis of nhanes 2007 2010 |
| topic | Constipation Diarrhea Cross-sectional study Oxidative balance score NHANES |
| url | https://doi.org/10.1186/s12876-025-03597-5 |
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