Viral Interference and Persistence in Mosquito-Borne Flaviviruses
Mosquito-borne flaviviruses are important pathogens for humans, and the detection of two or more flaviviruses cocirculating in the same geographic area has often been reported. However, the epidemiological impact remains to be determined. Mosquito-borne flaviviruses are primarily transmitted through...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/873404 |
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| author | Juan Santiago Salas-Benito Mónica De Nova-Ocampo |
| author_facet | Juan Santiago Salas-Benito Mónica De Nova-Ocampo |
| author_sort | Juan Santiago Salas-Benito |
| collection | DOAJ |
| description | Mosquito-borne flaviviruses are important pathogens for humans, and the detection of two or more flaviviruses cocirculating in the same geographic area has often been reported. However, the epidemiological impact remains to be determined. Mosquito-borne flaviviruses are primarily transmitted through Aedes and Culex mosquitoes; these viruses establish a life-long or persistent infection without apparent pathological effects. This establishment requires a balance between virus replication and the antiviral host response. Viral interference is a phenomenon whereby one virus inhibits the replication of other viruses, and this condition is frequently associated with persistent infections. Viral interference and persistent infection are determined by several factors, such as defective interfering particles, competition for cellular factors required for translation/replication, and the host antiviral response. The interaction between two flaviviruses typically results in viral interference, indicating that these viruses share common features during the replicative cycle in the vector. The potential mechanisms involved in these processes are reviewed here. |
| format | Article |
| id | doaj-art-6fb986a1d82d4fccb6357f4624868905 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-6fb986a1d82d4fccb6357f46248689052025-02-03T06:01:13ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/873404873404Viral Interference and Persistence in Mosquito-Borne FlavivirusesJuan Santiago Salas-Benito0Mónica De Nova-Ocampo1Programa Institucional de Biomedicina Molecular, Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, 07320 Mexico, DF, MexicoPrograma Institucional de Biomedicina Molecular, Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, 07320 Mexico, DF, MexicoMosquito-borne flaviviruses are important pathogens for humans, and the detection of two or more flaviviruses cocirculating in the same geographic area has often been reported. However, the epidemiological impact remains to be determined. Mosquito-borne flaviviruses are primarily transmitted through Aedes and Culex mosquitoes; these viruses establish a life-long or persistent infection without apparent pathological effects. This establishment requires a balance between virus replication and the antiviral host response. Viral interference is a phenomenon whereby one virus inhibits the replication of other viruses, and this condition is frequently associated with persistent infections. Viral interference and persistent infection are determined by several factors, such as defective interfering particles, competition for cellular factors required for translation/replication, and the host antiviral response. The interaction between two flaviviruses typically results in viral interference, indicating that these viruses share common features during the replicative cycle in the vector. The potential mechanisms involved in these processes are reviewed here.http://dx.doi.org/10.1155/2015/873404 |
| spellingShingle | Juan Santiago Salas-Benito Mónica De Nova-Ocampo Viral Interference and Persistence in Mosquito-Borne Flaviviruses Journal of Immunology Research |
| title | Viral Interference and Persistence in Mosquito-Borne Flaviviruses |
| title_full | Viral Interference and Persistence in Mosquito-Borne Flaviviruses |
| title_fullStr | Viral Interference and Persistence in Mosquito-Borne Flaviviruses |
| title_full_unstemmed | Viral Interference and Persistence in Mosquito-Borne Flaviviruses |
| title_short | Viral Interference and Persistence in Mosquito-Borne Flaviviruses |
| title_sort | viral interference and persistence in mosquito borne flaviviruses |
| url | http://dx.doi.org/10.1155/2015/873404 |
| work_keys_str_mv | AT juansantiagosalasbenito viralinterferenceandpersistenceinmosquitoborneflaviviruses AT monicadenovaocampo viralinterferenceandpersistenceinmosquitoborneflaviviruses |