Light-induced rearrangement from macrocyclic to bicyclic lactam: A case study of N-chlorinated laurolactam

Light-induced rearrangement from macrocyclic to bicyclic lactam: A case study of N-chlorinated laurolactam

Converting macrocycle lactams into bicyclic lactams is proposed as an additional way to further increase the metabolic stability of peptide-based drugs. Unfortunately, the synthesis of bicyclic lactams has to start almost from scratch. This study explores the Hofmann-Löffler-Freytag (HLF) reaction m...

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Bibliographic Details
Main Authors: Zubčić Gabrijel, Pavić Kristina, You Jiangyang, Vrček Valerije, Portada Tomislav, Bešić Erim, Šakić Davor
Format: Article
Language:English
Published: Sciendo 2024-12-01
Series:Acta Pharmaceutica
Subjects:
radical rearrangement
radical thermodynamics
ring-contraction
late-stage functionalisation
synthetic strategy
Online Access:https://doi.org/10.2478/acph-2024-0035
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