Spindle Bursts in Neonatal Rat Cerebral Cortex
Spontaneous and sensory evoked spindle bursts represent a functional hallmark of the developing cerebral cortex in vitro and in vivo. They have been observed in various neocortical areas of numerous species, including newborn rodents and preterm human infants. Spindle bursts are generated in complex...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/3467832 |
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| author | Jenq-Wei Yang Vicente Reyes-Puerta Werner Kilb Heiko J. Luhmann |
| author_facet | Jenq-Wei Yang Vicente Reyes-Puerta Werner Kilb Heiko J. Luhmann |
| author_sort | Jenq-Wei Yang |
| collection | DOAJ |
| description | Spontaneous and sensory evoked spindle bursts represent a functional hallmark of the developing cerebral cortex in vitro and in vivo. They have been observed in various neocortical areas of numerous species, including newborn rodents and preterm human infants. Spindle bursts are generated in complex neocortical-subcortical circuits involving in many cases the participation of motor brain regions. Together with early gamma oscillations, spindle bursts synchronize the activity of a local neuronal network organized in a cortical column. Disturbances in spindle burst activity during corticogenesis may contribute to disorders in cortical architecture and in the activity-dependent control of programmed cell death. In this review we discuss (i) the functional properties of spindle bursts, (ii) the mechanisms underlying their generation, (iii) the synchronous patterns and cortical networks associated with spindle bursts, and (iv) the physiological and pathophysiological role of spindle bursts during early cortical development. |
| format | Article |
| id | doaj-art-6fa9266dfc284cbbbf27d5488a5ccd58 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-6fa9266dfc284cbbbf27d5488a5ccd582025-02-03T06:11:16ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/34678323467832Spindle Bursts in Neonatal Rat Cerebral CortexJenq-Wei Yang0Vicente Reyes-Puerta1Werner Kilb2Heiko J. Luhmann3Institute of Physiology, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, GermanyInstitute of Physiology, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, GermanyInstitute of Physiology, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, GermanyInstitute of Physiology, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, GermanySpontaneous and sensory evoked spindle bursts represent a functional hallmark of the developing cerebral cortex in vitro and in vivo. They have been observed in various neocortical areas of numerous species, including newborn rodents and preterm human infants. Spindle bursts are generated in complex neocortical-subcortical circuits involving in many cases the participation of motor brain regions. Together with early gamma oscillations, spindle bursts synchronize the activity of a local neuronal network organized in a cortical column. Disturbances in spindle burst activity during corticogenesis may contribute to disorders in cortical architecture and in the activity-dependent control of programmed cell death. In this review we discuss (i) the functional properties of spindle bursts, (ii) the mechanisms underlying their generation, (iii) the synchronous patterns and cortical networks associated with spindle bursts, and (iv) the physiological and pathophysiological role of spindle bursts during early cortical development.http://dx.doi.org/10.1155/2016/3467832 |
| spellingShingle | Jenq-Wei Yang Vicente Reyes-Puerta Werner Kilb Heiko J. Luhmann Spindle Bursts in Neonatal Rat Cerebral Cortex Neural Plasticity |
| title | Spindle Bursts in Neonatal Rat Cerebral Cortex |
| title_full | Spindle Bursts in Neonatal Rat Cerebral Cortex |
| title_fullStr | Spindle Bursts in Neonatal Rat Cerebral Cortex |
| title_full_unstemmed | Spindle Bursts in Neonatal Rat Cerebral Cortex |
| title_short | Spindle Bursts in Neonatal Rat Cerebral Cortex |
| title_sort | spindle bursts in neonatal rat cerebral cortex |
| url | http://dx.doi.org/10.1155/2016/3467832 |
| work_keys_str_mv | AT jenqweiyang spindleburstsinneonatalratcerebralcortex AT vicentereyespuerta spindleburstsinneonatalratcerebralcortex AT wernerkilb spindleburstsinneonatalratcerebralcortex AT heikojluhmann spindleburstsinneonatalratcerebralcortex |