Airway Remodelling in Asthma and COPD: Findings, Similarities, and Differences Using Quantitative CT
Airway remodelling is a well-established feature in asthma and chronic obstructive lung disease (COPD), secondary to chronic airway inflammation. The structural changes found on pathological examination of remodelled airway wall have been shown to display similarities but also differences. Computed...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/670414 |
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| _version_ | 1832556392150466560 |
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| author | Gaël Dournes François Laurent |
| author_facet | Gaël Dournes François Laurent |
| author_sort | Gaël Dournes |
| collection | DOAJ |
| description | Airway remodelling is a well-established feature in asthma and chronic obstructive lung disease (COPD), secondary to chronic airway inflammation. The structural changes found on pathological examination of remodelled airway wall have been shown to display similarities but also differences. Computed tomography (CT) is today a remarkable tool to assess airway wall morphology in vivo since submillimetric acquisitions over the whole lung volume could be obtained allowing 3D evaluation. Recently, CT-derived indices extracted from CT images have been described and are thought to assess airway remodelling. This may help understand the complex mechanism underlying the remodelling process, which is still not fully understood. This paper summarizes the various methods described to quantify airway remodelling in asthma and COPD using CT, and similarities and differences between both diseases will be emphasized. |
| format | Article |
| id | doaj-art-6fa7ce638c6c4345a6111200dccd350f |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-6fa7ce638c6c4345a6111200dccd350f2025-02-03T05:45:31ZengWileyPulmonary Medicine2090-18362090-18442012-01-01201210.1155/2012/670414670414Airway Remodelling in Asthma and COPD: Findings, Similarities, and Differences Using Quantitative CTGaël Dournes0François Laurent1Department of Thoracic and Cardiovascular Imaging, CHU Bordeaux, avenue de Magellan, 33604 Pessac, FranceDepartment of Thoracic and Cardiovascular Imaging, CHU Bordeaux, avenue de Magellan, 33604 Pessac, FranceAirway remodelling is a well-established feature in asthma and chronic obstructive lung disease (COPD), secondary to chronic airway inflammation. The structural changes found on pathological examination of remodelled airway wall have been shown to display similarities but also differences. Computed tomography (CT) is today a remarkable tool to assess airway wall morphology in vivo since submillimetric acquisitions over the whole lung volume could be obtained allowing 3D evaluation. Recently, CT-derived indices extracted from CT images have been described and are thought to assess airway remodelling. This may help understand the complex mechanism underlying the remodelling process, which is still not fully understood. This paper summarizes the various methods described to quantify airway remodelling in asthma and COPD using CT, and similarities and differences between both diseases will be emphasized.http://dx.doi.org/10.1155/2012/670414 |
| spellingShingle | Gaël Dournes François Laurent Airway Remodelling in Asthma and COPD: Findings, Similarities, and Differences Using Quantitative CT Pulmonary Medicine |
| title | Airway Remodelling in Asthma and COPD: Findings, Similarities, and Differences Using Quantitative CT |
| title_full | Airway Remodelling in Asthma and COPD: Findings, Similarities, and Differences Using Quantitative CT |
| title_fullStr | Airway Remodelling in Asthma and COPD: Findings, Similarities, and Differences Using Quantitative CT |
| title_full_unstemmed | Airway Remodelling in Asthma and COPD: Findings, Similarities, and Differences Using Quantitative CT |
| title_short | Airway Remodelling in Asthma and COPD: Findings, Similarities, and Differences Using Quantitative CT |
| title_sort | airway remodelling in asthma and copd findings similarities and differences using quantitative ct |
| url | http://dx.doi.org/10.1155/2012/670414 |
| work_keys_str_mv | AT gaeldournes airwayremodellinginasthmaandcopdfindingssimilaritiesanddifferencesusingquantitativect AT francoislaurent airwayremodellinginasthmaandcopdfindingssimilaritiesanddifferencesusingquantitativect |