Autoimmune Hemolytic Anemia in a Renal Transplant Patient Following Seasonal Influenza Vaccination
Vaccines aim to prevent disease occurrence, its severity, and resultant complications. Our patient, a 58-year-old male, received seasonal influenza vaccination as part of routine health maintenance. Three days later, he presented with malaise, fever, and yellowish discoloration of eyes. His labs sho...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/3537418 |
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| author | Imran Gani George Hinnant Rajan Kapoor Natasha Savage |
| author_facet | Imran Gani George Hinnant Rajan Kapoor Natasha Savage |
| author_sort | Imran Gani |
| collection | DOAJ |
| description | Vaccines aim to prevent disease occurrence, its severity, and resultant complications. Our patient, a 58-year-old male, received seasonal influenza vaccination as part of routine health maintenance. Three days later, he presented with malaise, fever, and yellowish discoloration of eyes. His labs showed hyperbilirubinemia, anemia, elevated lactate dehydrogenase, and low haptoglobin, consistent with hemolytic anemia. Autoimmune hemolytic anemia has been associated with vaccine use and may result from phenomena of molecular mimicry and cross-reactivity with the possible role of vaccine adjuvants as well. An underlying structural defect of the red blood cell membrane may make them prone to hemolysis. The differential diagnosis and work-up of hemolytic anemia is extensive, as performed in our case. Management strategies for vaccine-induced hemolysis may involve supportive care, red blood cell transfusion, steroids, and intravenous immunoglobulin. |
| format | Article |
| id | doaj-art-6fa64861347244bb83fc6393d2f9595c |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-6fa64861347244bb83fc6393d2f9595c2025-02-03T06:48:38ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/35374183537418Autoimmune Hemolytic Anemia in a Renal Transplant Patient Following Seasonal Influenza VaccinationImran Gani0George Hinnant1Rajan Kapoor2Natasha Savage3Department of Nephrology, Hypertension and Transplant Medicine, Augusta University Health, Augusta, GeorgiaDepartment of Nephrology, Hypertension and Transplant Medicine, Augusta University Health, Augusta, GeorgiaDepartment of Nephrology, Hypertension and Transplant Medicine, Augusta University Health, Augusta, GeorgiaDepartment of Pathology, Augusta University Health, Augusta, GeorgiaVaccines aim to prevent disease occurrence, its severity, and resultant complications. Our patient, a 58-year-old male, received seasonal influenza vaccination as part of routine health maintenance. Three days later, he presented with malaise, fever, and yellowish discoloration of eyes. His labs showed hyperbilirubinemia, anemia, elevated lactate dehydrogenase, and low haptoglobin, consistent with hemolytic anemia. Autoimmune hemolytic anemia has been associated with vaccine use and may result from phenomena of molecular mimicry and cross-reactivity with the possible role of vaccine adjuvants as well. An underlying structural defect of the red blood cell membrane may make them prone to hemolysis. The differential diagnosis and work-up of hemolytic anemia is extensive, as performed in our case. Management strategies for vaccine-induced hemolysis may involve supportive care, red blood cell transfusion, steroids, and intravenous immunoglobulin.http://dx.doi.org/10.1155/2019/3537418 |
| spellingShingle | Imran Gani George Hinnant Rajan Kapoor Natasha Savage Autoimmune Hemolytic Anemia in a Renal Transplant Patient Following Seasonal Influenza Vaccination Case Reports in Hematology |
| title | Autoimmune Hemolytic Anemia in a Renal Transplant Patient Following Seasonal Influenza Vaccination |
| title_full | Autoimmune Hemolytic Anemia in a Renal Transplant Patient Following Seasonal Influenza Vaccination |
| title_fullStr | Autoimmune Hemolytic Anemia in a Renal Transplant Patient Following Seasonal Influenza Vaccination |
| title_full_unstemmed | Autoimmune Hemolytic Anemia in a Renal Transplant Patient Following Seasonal Influenza Vaccination |
| title_short | Autoimmune Hemolytic Anemia in a Renal Transplant Patient Following Seasonal Influenza Vaccination |
| title_sort | autoimmune hemolytic anemia in a renal transplant patient following seasonal influenza vaccination |
| url | http://dx.doi.org/10.1155/2019/3537418 |
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