Assessment of Atrial Conduction Times in Patients with Newly Diagnosed Parkinson’s Disease
Background. An increased risk of ischemic stroke has been reported in patients with Parkinson’s disease (PD). Atrial fibrillation (AF) is strongly associated with ischemic stroke. Prolonged atrial electromechanical delay (EMD) is an independent predictor for the development of AF. Aims. The aim of t...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2018/2916905 |
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| author | Yiğit Çanga Ayşe Emre Gülbün Asuman Yüksel Mehmet Baran Karataş Nizamettin Selçuk Yelgeç Ufuk Gürkan Ali Nazmi Çalık Hülya Tireli Sait Terzi |
| author_facet | Yiğit Çanga Ayşe Emre Gülbün Asuman Yüksel Mehmet Baran Karataş Nizamettin Selçuk Yelgeç Ufuk Gürkan Ali Nazmi Çalık Hülya Tireli Sait Terzi |
| author_sort | Yiğit Çanga |
| collection | DOAJ |
| description | Background. An increased risk of ischemic stroke has been reported in patients with Parkinson’s disease (PD). Atrial fibrillation (AF) is strongly associated with ischemic stroke. Prolonged atrial electromechanical delay (EMD) is an independent predictor for the development of AF. Aims. The aim of the present study was to evaluate the atrial conduction parameters in patients with PD and to assess their relation with the severity of PD. Study design. We prospectively enrolled 51 consecutive patients with newly diagnosed PD and 31 age- and sex-matched non-PD subjects. Methods. To assess atrial electromechanical coupling (PA), the time intervals from the onset of p wave on ECG to the late diastolic wave at the septal (PAs) and lateral (PAl) mitral annulus and lateral tricuspid annulus (PAt) were measured on Tissue Doppler Echocardiography (TDE). The difference between PAs-PAl, PAs-PAt, and PAl-PAt were defined as left intra-atrial, right intra-atrial, and interatrial EMD, respectively. P-wave dispersion (PWD) was calculated from the 12-lead ECG. Results. PWD, PAs, PAl, and PAt durations were significantly prolonged in the PD group (all p<0.001). Interatrial, right, and left intra-atrial EMD were also significantly longer in PD patients (p<0.001, p<0.001 and p=0.002, resp.). There were significant positive correlations between disease severity (UPDRS score) and PWD (r=0.34, p=0.041), left intra-atrial (r=0.39, p=0.005), and interatrial EMD (r=0.35, p=0.012). By multivariate analysis, PWD (OR: 1.13, 95% CI: 1.02–1.25; p=0.017), LA volume index (OR: 1.19, 95% CI: 1.02–1.37; p=0.021), left intra-atrial (OR: 1.12, 95% CI: 1.01–1.24; p=0.041), and interatrial EMD (OR: 1.08, 95% CI: 1.01–1.16; p=0.026) were found as independent predictors of PD. Conclusion. Atrial conduction times were longer and correlated with the severity of disease in PD patients. Prolonged inter- and intra-atrial-EMD intervals were also found as independent correlates of PD. These findings may suggest an increased predisposition to atrial fibrillation in PD. |
| format | Article |
| id | doaj-art-6f9a29ec317244b589aa1043deb8fad0 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-6f9a29ec317244b589aa1043deb8fad02025-02-03T06:13:38ZengWileyParkinson's Disease2090-80832042-00802018-01-01201810.1155/2018/29169052916905Assessment of Atrial Conduction Times in Patients with Newly Diagnosed Parkinson’s DiseaseYiğit Çanga0Ayşe Emre1Gülbün Asuman Yüksel2Mehmet Baran Karataş3Nizamettin Selçuk Yelgeç4Ufuk Gürkan5Ali Nazmi Çalık6Hülya Tireli7Sait Terzi8Department of Cardiology, Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, TurkeyDepartment of Cardiology, Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, TurkeyDepartment of Neurology, Haydarpasa Numune Training and Research Hospital, Istanbul, TurkeyDepartment of Cardiology, Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, TurkeyDepartment of Cardiology, Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, TurkeyDepartment of Cardiology, Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, TurkeyDepartment of Cardiology, Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, TurkeyDepartment of Neurology, Haydarpasa Numune Training and Research Hospital, Istanbul, TurkeyDepartment of Cardiology, Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, TurkeyBackground. An increased risk of ischemic stroke has been reported in patients with Parkinson’s disease (PD). Atrial fibrillation (AF) is strongly associated with ischemic stroke. Prolonged atrial electromechanical delay (EMD) is an independent predictor for the development of AF. Aims. The aim of the present study was to evaluate the atrial conduction parameters in patients with PD and to assess their relation with the severity of PD. Study design. We prospectively enrolled 51 consecutive patients with newly diagnosed PD and 31 age- and sex-matched non-PD subjects. Methods. To assess atrial electromechanical coupling (PA), the time intervals from the onset of p wave on ECG to the late diastolic wave at the septal (PAs) and lateral (PAl) mitral annulus and lateral tricuspid annulus (PAt) were measured on Tissue Doppler Echocardiography (TDE). The difference between PAs-PAl, PAs-PAt, and PAl-PAt were defined as left intra-atrial, right intra-atrial, and interatrial EMD, respectively. P-wave dispersion (PWD) was calculated from the 12-lead ECG. Results. PWD, PAs, PAl, and PAt durations were significantly prolonged in the PD group (all p<0.001). Interatrial, right, and left intra-atrial EMD were also significantly longer in PD patients (p<0.001, p<0.001 and p=0.002, resp.). There were significant positive correlations between disease severity (UPDRS score) and PWD (r=0.34, p=0.041), left intra-atrial (r=0.39, p=0.005), and interatrial EMD (r=0.35, p=0.012). By multivariate analysis, PWD (OR: 1.13, 95% CI: 1.02–1.25; p=0.017), LA volume index (OR: 1.19, 95% CI: 1.02–1.37; p=0.021), left intra-atrial (OR: 1.12, 95% CI: 1.01–1.24; p=0.041), and interatrial EMD (OR: 1.08, 95% CI: 1.01–1.16; p=0.026) were found as independent predictors of PD. Conclusion. Atrial conduction times were longer and correlated with the severity of disease in PD patients. Prolonged inter- and intra-atrial-EMD intervals were also found as independent correlates of PD. These findings may suggest an increased predisposition to atrial fibrillation in PD.http://dx.doi.org/10.1155/2018/2916905 |
| spellingShingle | Yiğit Çanga Ayşe Emre Gülbün Asuman Yüksel Mehmet Baran Karataş Nizamettin Selçuk Yelgeç Ufuk Gürkan Ali Nazmi Çalık Hülya Tireli Sait Terzi Assessment of Atrial Conduction Times in Patients with Newly Diagnosed Parkinson’s Disease Parkinson's Disease |
| title | Assessment of Atrial Conduction Times in Patients with Newly Diagnosed Parkinson’s Disease |
| title_full | Assessment of Atrial Conduction Times in Patients with Newly Diagnosed Parkinson’s Disease |
| title_fullStr | Assessment of Atrial Conduction Times in Patients with Newly Diagnosed Parkinson’s Disease |
| title_full_unstemmed | Assessment of Atrial Conduction Times in Patients with Newly Diagnosed Parkinson’s Disease |
| title_short | Assessment of Atrial Conduction Times in Patients with Newly Diagnosed Parkinson’s Disease |
| title_sort | assessment of atrial conduction times in patients with newly diagnosed parkinson s disease |
| url | http://dx.doi.org/10.1155/2018/2916905 |
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