Diagnostic Value of Peripheral Lymph Node Biopsy in Sarcoidosis: A Report of 67 Cases
A peripheral lymph node (PLN) 1 cm or greater was found in 79 of 546 sarcoidosis patients (14.5%) between 1972 and 2005. Seventy-two of the 79 sarcoidosis patients had a lymph node biopsy performed. Sixty-seven of these biopsy specimens were histologically diagnosed as sarcoidosis, whereas five pati...
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| Language: | English |
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Wiley
2007-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2007/218947 |
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| author | Halil Yanardag Metin Caner Irfan Papila Sedat Uygun Sabriye Demirci Tuncer Karayel |
| author_facet | Halil Yanardag Metin Caner Irfan Papila Sedat Uygun Sabriye Demirci Tuncer Karayel |
| author_sort | Halil Yanardag |
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| description | A peripheral lymph node (PLN) 1 cm or greater was found in 79 of 546 sarcoidosis patients (14.5%) between 1972 and 2005. Seventy-two of the 79 sarcoidosis patients had a lymph node biopsy performed. Sixty-seven of these biopsy specimens were histologically diagnosed as sarcoidosis, whereas five patients had a reactive adenopathy. For patients with histological diagnosis of sarcoidosis, localizations of the biopsies were as follows: cervical (n=21), supra-clavicular (n=20), inguinal (n=11), axillary (n=8), epitrochlear (n=5) and submandibular (n=2). At the time of biopsy, 12 patients had stage 0 disease, 37 patients had stage I disease, 14 patients had stage II disease and four patients had stage III disease. Skin involvement (16.4%) was the most frequently observed type of organ involvement in patients who had enlarged PLNs due to sarcoidosis. In the presence of an enlarged PLN in sarcoidosis, biopsy had a greater diagnostic value compared with other methods, as well as having a relatively low cost (approximately US$120) in Turkey. No procedure-related complications were observed. In conclusion, it is recommended that PLNs be thoroughly examined when sarcoidosis is suspected. If an enlarged PLN is found, biopsy should be routinely performed because it is an easy, convenient and practical method, with a low complication risk and a high sensitivity. |
| format | Article |
| id | doaj-art-6f90a7231eb7495c9a4c58b76efdb69f |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-6f90a7231eb7495c9a4c58b76efdb69f2025-02-03T01:26:26ZengWileyCanadian Respiratory Journal1198-22412007-01-0114420921110.1155/2007/218947Diagnostic Value of Peripheral Lymph Node Biopsy in Sarcoidosis: A Report of 67 CasesHalil Yanardag0Metin Caner1Irfan Papila2Sedat Uygun3Sabriye Demirci4Tuncer Karayel51Department of Lung Diseases;, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, TurkeyDepartment of Surgery, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, TurkeyDepartment of Otolaryngology, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey1Department of Lung Diseases;, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey1Department of Lung Diseases;, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey1Department of Lung Diseases;, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, TurkeyA peripheral lymph node (PLN) 1 cm or greater was found in 79 of 546 sarcoidosis patients (14.5%) between 1972 and 2005. Seventy-two of the 79 sarcoidosis patients had a lymph node biopsy performed. Sixty-seven of these biopsy specimens were histologically diagnosed as sarcoidosis, whereas five patients had a reactive adenopathy. For patients with histological diagnosis of sarcoidosis, localizations of the biopsies were as follows: cervical (n=21), supra-clavicular (n=20), inguinal (n=11), axillary (n=8), epitrochlear (n=5) and submandibular (n=2). At the time of biopsy, 12 patients had stage 0 disease, 37 patients had stage I disease, 14 patients had stage II disease and four patients had stage III disease. Skin involvement (16.4%) was the most frequently observed type of organ involvement in patients who had enlarged PLNs due to sarcoidosis. In the presence of an enlarged PLN in sarcoidosis, biopsy had a greater diagnostic value compared with other methods, as well as having a relatively low cost (approximately US$120) in Turkey. No procedure-related complications were observed. In conclusion, it is recommended that PLNs be thoroughly examined when sarcoidosis is suspected. If an enlarged PLN is found, biopsy should be routinely performed because it is an easy, convenient and practical method, with a low complication risk and a high sensitivity.http://dx.doi.org/10.1155/2007/218947 |
| spellingShingle | Halil Yanardag Metin Caner Irfan Papila Sedat Uygun Sabriye Demirci Tuncer Karayel Diagnostic Value of Peripheral Lymph Node Biopsy in Sarcoidosis: A Report of 67 Cases Canadian Respiratory Journal |
| title | Diagnostic Value of Peripheral Lymph Node Biopsy in Sarcoidosis: A Report of 67 Cases |
| title_full | Diagnostic Value of Peripheral Lymph Node Biopsy in Sarcoidosis: A Report of 67 Cases |
| title_fullStr | Diagnostic Value of Peripheral Lymph Node Biopsy in Sarcoidosis: A Report of 67 Cases |
| title_full_unstemmed | Diagnostic Value of Peripheral Lymph Node Biopsy in Sarcoidosis: A Report of 67 Cases |
| title_short | Diagnostic Value of Peripheral Lymph Node Biopsy in Sarcoidosis: A Report of 67 Cases |
| title_sort | diagnostic value of peripheral lymph node biopsy in sarcoidosis a report of 67 cases |
| url | http://dx.doi.org/10.1155/2007/218947 |
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