Computer modeling of the peculiarities in the interaction of IL-1 with its receptors in schizophrenia
One of the primary theories regarding the development of schizophrenia revolves around genetics, indicating the involvement of hereditary factors in various processes, including inflammation. Research has demonstrated that inflammatory reactions occurring in microglia can impact the progression of t...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2024-05-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/4147 |
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| author | N. Yu. Chasovskikh A. A. Bobrysheva E. E. Chizhik |
| author_facet | N. Yu. Chasovskikh A. A. Bobrysheva E. E. Chizhik |
| author_sort | N. Yu. Chasovskikh |
| collection | DOAJ |
| description | One of the primary theories regarding the development of schizophrenia revolves around genetics, indicating the involvement of hereditary factors in various processes, including inflammation. Research has demonstrated that inflammatory reactions occurring in microglia can impact the progression of the disease. It has also been established that genetically determined changes in IL-1 can contribute to schizophrenia, thereby confirming the role of the IL-1 gene cluster in disease susceptibility. The aim of this study is a computer-based assessment of the structural interactions of IL-1 proteins with their receptors in schizophrenia. The study utilized the DisGeNET database, enabling the assessment of the reliability of identified IL-1 polymorphisms. Polymorphisms were also sought using NCBI PubMed. The NCBI Protein service was employed to search for and analyze the position of the identified polymorphisms on the chromosome. Structures for modeling were extracted from the Protein Data Bank database. Protein modeling was conducted using the SWISS-MODEL server, and protein interaction modeling was performed using PRISM. Notably, this study represents the first prediction of the interactions of IL-1α, IL-1β, and IL- 1RA proteins, taking into account the presence of single-nucleotide polymorphisms associated with schizophrenia in the sequence of the corresponding genes. The results indicate that the presence of SNP rs315952 in the IL-1RA protein gene, associated with schizophrenia, may lead to a weakening of the IL-1RA binding to receptors, potentially triggering the initiation of the IL-1 signaling pathway by disrupting or weakening the IL-1RA binding to receptors and facilitating the binding of IL-1 to them. Such alterations could potentially lead to a change in the immune response. The data obtained contribute theoretically to the development of ideas about the molecular mechanisms through which hereditary factors in schizophrenia influence the interactions of proteins of the IL-1 family, which play an important role in the processes of the immune system. |
| format | Article |
| id | doaj-art-6f8d9ffaf0574660b401710ed1cb049c |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-6f8d9ffaf0574660b401710ed1cb049c2025-02-01T09:58:13ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592024-05-0128333234110.18699/vjgb-24-381468Computer modeling of the peculiarities in the interaction of IL-1 with its receptors in schizophreniaN. Yu. Chasovskikh0A. A. Bobrysheva1E. E. Chizhik2Siberian State Medical University of the Ministry of Healthcare of the Russian FederationSiberian State Medical University of the Ministry of Healthcare of the Russian FederationSiberian State Medical University of the Ministry of Healthcare of the Russian FederationOne of the primary theories regarding the development of schizophrenia revolves around genetics, indicating the involvement of hereditary factors in various processes, including inflammation. Research has demonstrated that inflammatory reactions occurring in microglia can impact the progression of the disease. It has also been established that genetically determined changes in IL-1 can contribute to schizophrenia, thereby confirming the role of the IL-1 gene cluster in disease susceptibility. The aim of this study is a computer-based assessment of the structural interactions of IL-1 proteins with their receptors in schizophrenia. The study utilized the DisGeNET database, enabling the assessment of the reliability of identified IL-1 polymorphisms. Polymorphisms were also sought using NCBI PubMed. The NCBI Protein service was employed to search for and analyze the position of the identified polymorphisms on the chromosome. Structures for modeling were extracted from the Protein Data Bank database. Protein modeling was conducted using the SWISS-MODEL server, and protein interaction modeling was performed using PRISM. Notably, this study represents the first prediction of the interactions of IL-1α, IL-1β, and IL- 1RA proteins, taking into account the presence of single-nucleotide polymorphisms associated with schizophrenia in the sequence of the corresponding genes. The results indicate that the presence of SNP rs315952 in the IL-1RA protein gene, associated with schizophrenia, may lead to a weakening of the IL-1RA binding to receptors, potentially triggering the initiation of the IL-1 signaling pathway by disrupting or weakening the IL-1RA binding to receptors and facilitating the binding of IL-1 to them. Such alterations could potentially lead to a change in the immune response. The data obtained contribute theoretically to the development of ideas about the molecular mechanisms through which hereditary factors in schizophrenia influence the interactions of proteins of the IL-1 family, which play an important role in the processes of the immune system.https://vavilov.elpub.ru/jour/article/view/4147il-1schizophreniamolecular modelingsnpsingle-nucleotide polymorphismsprism |
| spellingShingle | N. Yu. Chasovskikh A. A. Bobrysheva E. E. Chizhik Computer modeling of the peculiarities in the interaction of IL-1 with its receptors in schizophrenia Вавиловский журнал генетики и селекции il-1 schizophrenia molecular modeling snp single-nucleotide polymorphisms prism |
| title | Computer modeling of the peculiarities in the interaction of IL-1 with its receptors in schizophrenia |
| title_full | Computer modeling of the peculiarities in the interaction of IL-1 with its receptors in schizophrenia |
| title_fullStr | Computer modeling of the peculiarities in the interaction of IL-1 with its receptors in schizophrenia |
| title_full_unstemmed | Computer modeling of the peculiarities in the interaction of IL-1 with its receptors in schizophrenia |
| title_short | Computer modeling of the peculiarities in the interaction of IL-1 with its receptors in schizophrenia |
| title_sort | computer modeling of the peculiarities in the interaction of il 1 with its receptors in schizophrenia |
| topic | il-1 schizophrenia molecular modeling snp single-nucleotide polymorphisms prism |
| url | https://vavilov.elpub.ru/jour/article/view/4147 |
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