Advances in Chemical Synthesis of Fondaparinux
Fondaparinux (trade name Arixtra) is a safe and efficacious anticoagulant, and it is chemically related to low-molecular-weight heparins such as enoxaparin. Fondaparinux is a synthetic pentasaccharide, and its synthesis is difficult and expensive. The high cost of fondaparinux thwarts its extensive...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2019/9545297 |
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| author | Yili Ding Chamakura V. N. S. Vara Prasad Bingyun Wang |
| author_facet | Yili Ding Chamakura V. N. S. Vara Prasad Bingyun Wang |
| author_sort | Yili Ding |
| collection | DOAJ |
| description | Fondaparinux (trade name Arixtra) is a safe and efficacious anticoagulant, and it is chemically related to low-molecular-weight heparins such as enoxaparin. Fondaparinux is a synthetic pentasaccharide, and its synthesis is difficult and expensive. The high cost of fondaparinux thwarts its extensive worldwide usage. Over the last two decades, several research groups and pharmaceutical companies have been interested in finding efficient and practical methods for its synthesis. The present review discusses those strategies and their pros and cons in a comparative account. |
| format | Article |
| id | doaj-art-6f88b897124f4120aab85c2139842686 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-6f88b897124f4120aab85c21398426862025-02-03T01:11:27ZengWileyJournal of Chemistry2090-90632090-90712019-01-01201910.1155/2019/95452979545297Advances in Chemical Synthesis of FondaparinuxYili Ding0Chamakura V. N. S. Vara Prasad1Bingyun Wang2Life Science Department, Foshan University, Foshan, Guangdong 528000, ChinaDas Pharma, Turangi P.O., Kakinada, AP 533016, IndiaLife Science Department, Foshan University, Foshan, Guangdong 528000, ChinaFondaparinux (trade name Arixtra) is a safe and efficacious anticoagulant, and it is chemically related to low-molecular-weight heparins such as enoxaparin. Fondaparinux is a synthetic pentasaccharide, and its synthesis is difficult and expensive. The high cost of fondaparinux thwarts its extensive worldwide usage. Over the last two decades, several research groups and pharmaceutical companies have been interested in finding efficient and practical methods for its synthesis. The present review discusses those strategies and their pros and cons in a comparative account.http://dx.doi.org/10.1155/2019/9545297 |
| spellingShingle | Yili Ding Chamakura V. N. S. Vara Prasad Bingyun Wang Advances in Chemical Synthesis of Fondaparinux Journal of Chemistry |
| title | Advances in Chemical Synthesis of Fondaparinux |
| title_full | Advances in Chemical Synthesis of Fondaparinux |
| title_fullStr | Advances in Chemical Synthesis of Fondaparinux |
| title_full_unstemmed | Advances in Chemical Synthesis of Fondaparinux |
| title_short | Advances in Chemical Synthesis of Fondaparinux |
| title_sort | advances in chemical synthesis of fondaparinux |
| url | http://dx.doi.org/10.1155/2019/9545297 |
| work_keys_str_mv | AT yiliding advancesinchemicalsynthesisoffondaparinux AT chamakuravnsvaraprasad advancesinchemicalsynthesisoffondaparinux AT bingyunwang advancesinchemicalsynthesisoffondaparinux |