Unique Cytokine Signature in the Plasma of Patients with Fibromyalgia
Fibromyalgia (FMS) is a chronic pain syndrome with a complex but poorly understood pathogenesis affecting approximately 10 million adults in the United States. The lack of a clear etiology of FMS has limited the effective diagnosis and treatment of this debilitating condition. The objective of this...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/938576 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567234115928064 |
|---|---|
| author | Jamie Sturgill Elizabeth McGee Victoria Menzies |
| author_facet | Jamie Sturgill Elizabeth McGee Victoria Menzies |
| author_sort | Jamie Sturgill |
| collection | DOAJ |
| description | Fibromyalgia (FMS) is a chronic pain syndrome with a complex but poorly understood pathogenesis affecting approximately 10 million adults in the United States. The lack of a clear etiology of FMS has limited the effective diagnosis and treatment of this debilitating condition. The objective of this secondary data analysis was to examine plasma cytokine levels in women with FMS using the Bio-Plex Human Cytokine 17-plex Assay. Post hoc analysis of plasma cytokine levels was performed to evaluate patterns that were not specified a priori. Upon examination, patients with FMS exhibited a marked reduction in TH2 cytokines such as IL-4, IL-5, and IL-13. The finding of this pattern of altered cytokine milieu not only supports the role of inflammation in FMS but also may lead to more definitive diagnostic tools for clinicians treating FMS. The TH2 suppression provides strong evidence of immune dysregulation in patients with FMS. |
| format | Article |
| id | doaj-art-6f7e36ce578b4626b8431fafbc2648b5 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-6f7e36ce578b4626b8431fafbc2648b52025-02-03T01:02:01ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/938576938576Unique Cytokine Signature in the Plasma of Patients with FibromyalgiaJamie Sturgill0Elizabeth McGee1Victoria Menzies2School of Nursing, Virginia Commonwealth University, Richmond, VA 23298, USAInstitute of Women’s Health, Virginia Commonwealth University, Richmond, VA 23298, USASchool of Nursing, Virginia Commonwealth University, Richmond, VA 23298, USAFibromyalgia (FMS) is a chronic pain syndrome with a complex but poorly understood pathogenesis affecting approximately 10 million adults in the United States. The lack of a clear etiology of FMS has limited the effective diagnosis and treatment of this debilitating condition. The objective of this secondary data analysis was to examine plasma cytokine levels in women with FMS using the Bio-Plex Human Cytokine 17-plex Assay. Post hoc analysis of plasma cytokine levels was performed to evaluate patterns that were not specified a priori. Upon examination, patients with FMS exhibited a marked reduction in TH2 cytokines such as IL-4, IL-5, and IL-13. The finding of this pattern of altered cytokine milieu not only supports the role of inflammation in FMS but also may lead to more definitive diagnostic tools for clinicians treating FMS. The TH2 suppression provides strong evidence of immune dysregulation in patients with FMS.http://dx.doi.org/10.1155/2014/938576 |
| spellingShingle | Jamie Sturgill Elizabeth McGee Victoria Menzies Unique Cytokine Signature in the Plasma of Patients with Fibromyalgia Journal of Immunology Research |
| title | Unique Cytokine Signature in the Plasma of Patients with Fibromyalgia |
| title_full | Unique Cytokine Signature in the Plasma of Patients with Fibromyalgia |
| title_fullStr | Unique Cytokine Signature in the Plasma of Patients with Fibromyalgia |
| title_full_unstemmed | Unique Cytokine Signature in the Plasma of Patients with Fibromyalgia |
| title_short | Unique Cytokine Signature in the Plasma of Patients with Fibromyalgia |
| title_sort | unique cytokine signature in the plasma of patients with fibromyalgia |
| url | http://dx.doi.org/10.1155/2014/938576 |
| work_keys_str_mv | AT jamiesturgill uniquecytokinesignatureintheplasmaofpatientswithfibromyalgia AT elizabethmcgee uniquecytokinesignatureintheplasmaofpatientswithfibromyalgia AT victoriamenzies uniquecytokinesignatureintheplasmaofpatientswithfibromyalgia |