ROLE OF GENETIC VARIABILITY IN METABOLIC PATHWAYS ON CISPLATIN-INDUCED KIDNEY INJURY IN HEAD AND NECK CANCER PATIENTS

ROLE OF GENETIC VARIABILITY IN METABOLIC PATHWAYS ON CISPLATIN-INDUCED KIDNEY INJURY IN HEAD AND NECK CANCER PATIENTS

Introduction/Justification: Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy responsible for approximately 5.0% of global cancer deaths. The standard treatment for locally advanced HNSCC involves cisplatin (CDDP)-based chemotherapy and radiotherapy, which can lead to significa...

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Bibliographic Details
Main Authors: Ericka Francislaine Dias Costa, Ana Maria Castro Ferreira, Marilda Mazzali, Gustavo Jacob Lourenço, Carmen Silvia Passos Lima
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Hematology, Transfusion and Cell Therapy
Subjects:
Cisplatin
Head and neck squamous cell carcinoma
Nephrotoxicity
Single nucleotide variants
Online Access:http://www.sciencedirect.com/science/article/pii/S2531137925000355
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