Liposarcomas of the hypopharynx: a systematic review of the literature
Introduction: Liposarcomas are considered the most common type of soft tissue sarcoma in adults. They represent approximately 20% of all mesenchymal malignancies and most frequently involve the retroperitoneum, trunk and extremities. Hypopharyngeal localisation of a liposarcoma is extremely rare. T...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Edizioni FS
2016-03-01
|
| Series: | Journal of Health and Social Sciences |
| Subjects: | |
| Online Access: | http://journalhss.com/wp-content/uploads/JHHS1157-66.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832595543609573376 |
|---|---|
| author | Andrea Corvino Giuseppe Riva Matteo Sensini Massimiliano Garzaro Giancarlo Pecorari |
| author_facet | Andrea Corvino Giuseppe Riva Matteo Sensini Massimiliano Garzaro Giancarlo Pecorari |
| author_sort | Andrea Corvino |
| collection | DOAJ |
| description | Introduction: Liposarcomas are considered the most common type of soft tissue sarcoma in adults. They represent approximately 20% of all mesenchymal malignancies and most frequently involve
the retroperitoneum, trunk and extremities. Hypopharyngeal localisation of a liposarcoma is extremely rare. To determine the prevalence of liposarcomas of the hypopharynx, we conducted a
systematic review of the literature.
Methods: We performed a systematic search of the literature until 2015 using PubMed and Ovid. The search identified 28 cases of hypopharyngeal liposarcomas. The inclusion criteria were: clinical
trials, cohort studies, case-control studies, case reports and case series on hypopharyngeal liposarcomas. From an initial 77 articles, 23 articles were selected for this systematic review. The natural history, imaging features, histology, treatment and prognosis were analysed.
Results: The incidence peaked in the sixth and seventh decades. Diagnostic procedures were based on the barium swallow test, endoscopic examinations, and computed tomography (CT)/magnetic resonance (MR) imaging. A well-differentiated liposarcoma represented the most frequent histological
subtype. Surgical excision was the main treatment. Endoscopic resection appeared to be useful for peduncolated tumours of the hypopharynx. The 1-year disease-free survival rate was
89.47%.
Conclusions: A hypopharyngeal liposarcoma is a rare pathology, but it should kept in mind when a mass of the hypopharynx is discovered. A cervical approach is better, irrespective of the size of the tumour, except for cases in which an endoscopic approach is feasible. Local recurrence is common. Therefore, patients should undergo regular examinations, at least for up to 5 years. |
| format | Article |
| id | doaj-art-6f7c91e9cd5141158cded30a39726d68 |
| institution | Kabale University |
| issn | 2499-2240 2499-5886 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | Edizioni FS |
| record_format | Article |
| series | Journal of Health and Social Sciences |
| spelling | doaj-art-6f7c91e9cd5141158cded30a39726d682025-01-18T18:20:31ZengEdizioni FSJournal of Health and Social Sciences2499-22402499-58862016-03-0111576610.19204/2016/lpsr8Liposarcomas of the hypopharynx: a systematic review of the literatureAndrea Corvino0Giuseppe Riva1Matteo Sensini2Massimiliano Garzaro3Giancarlo Pecorari4ENT Division, Surgical Sciences Department, University of Turin, Via Genova,3,10126 Turin, ItalyENT Division, Surgical Sciences Department, University of Turin, Via Genova,3,10126 Turin, ItalyENT Division, Surgical Sciences Department, University of Turin, Via Genova,3,10126 Turin, ItalyENT Division, Surgical Sciences Department, University of Turin, Via Genova,3,10126 Turin, ItalyENT Division, Surgical Sciences Department, University of Turin, Via Genova,3,10126 Turin, ItalyIntroduction: Liposarcomas are considered the most common type of soft tissue sarcoma in adults. They represent approximately 20% of all mesenchymal malignancies and most frequently involve the retroperitoneum, trunk and extremities. Hypopharyngeal localisation of a liposarcoma is extremely rare. To determine the prevalence of liposarcomas of the hypopharynx, we conducted a systematic review of the literature. Methods: We performed a systematic search of the literature until 2015 using PubMed and Ovid. The search identified 28 cases of hypopharyngeal liposarcomas. The inclusion criteria were: clinical trials, cohort studies, case-control studies, case reports and case series on hypopharyngeal liposarcomas. From an initial 77 articles, 23 articles were selected for this systematic review. The natural history, imaging features, histology, treatment and prognosis were analysed. Results: The incidence peaked in the sixth and seventh decades. Diagnostic procedures were based on the barium swallow test, endoscopic examinations, and computed tomography (CT)/magnetic resonance (MR) imaging. A well-differentiated liposarcoma represented the most frequent histological subtype. Surgical excision was the main treatment. Endoscopic resection appeared to be useful for peduncolated tumours of the hypopharynx. The 1-year disease-free survival rate was 89.47%. Conclusions: A hypopharyngeal liposarcoma is a rare pathology, but it should kept in mind when a mass of the hypopharynx is discovered. A cervical approach is better, irrespective of the size of the tumour, except for cases in which an endoscopic approach is feasible. Local recurrence is common. Therefore, patients should undergo regular examinations, at least for up to 5 years.http://journalhss.com/wp-content/uploads/JHHS1157-66.pdfliposarcoma; hypopharyngeal neoplasms; hypopharynx; piriform sinus |
| spellingShingle | Andrea Corvino Giuseppe Riva Matteo Sensini Massimiliano Garzaro Giancarlo Pecorari Liposarcomas of the hypopharynx: a systematic review of the literature Journal of Health and Social Sciences liposarcoma; hypopharyngeal neoplasms; hypopharynx; piriform sinus |
| title | Liposarcomas of the hypopharynx: a systematic review of the literature |
| title_full | Liposarcomas of the hypopharynx: a systematic review of the literature |
| title_fullStr | Liposarcomas of the hypopharynx: a systematic review of the literature |
| title_full_unstemmed | Liposarcomas of the hypopharynx: a systematic review of the literature |
| title_short | Liposarcomas of the hypopharynx: a systematic review of the literature |
| title_sort | liposarcomas of the hypopharynx a systematic review of the literature |
| topic | liposarcoma; hypopharyngeal neoplasms; hypopharynx; piriform sinus |
| url | http://journalhss.com/wp-content/uploads/JHHS1157-66.pdf |
| work_keys_str_mv | AT andreacorvino liposarcomasofthehypopharynxasystematicreviewoftheliterature AT giusepperiva liposarcomasofthehypopharynxasystematicreviewoftheliterature AT matteosensini liposarcomasofthehypopharynxasystematicreviewoftheliterature AT massimilianogarzaro liposarcomasofthehypopharynxasystematicreviewoftheliterature AT giancarlopecorari liposarcomasofthehypopharynxasystematicreviewoftheliterature |