Lessons Learned and Questions Raised by an Atypical Case of Clozapine-Induced Myocarditis
A Caucasian male in his early twenties suffering from treatment resistant schizophrenia was started on clozapine. After three days he developed tachycardia, a common side effect of clozapine induction. He had one temperature spike (38.9°C) on day ten after induction but remained clinically well. An...
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| Format: | Article |
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Wiley
2016-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2016/4159081 |
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| author | Charles H. Earnshaw Lucy Powell Owen Haeney |
| author_facet | Charles H. Earnshaw Lucy Powell Owen Haeney |
| author_sort | Charles H. Earnshaw |
| collection | DOAJ |
| description | A Caucasian male in his early twenties suffering from treatment resistant schizophrenia was started on clozapine. After three days he developed tachycardia, a common side effect of clozapine induction. He had one temperature spike (38.9°C) on day ten after induction but remained clinically well. An ECG and blood tests were normal. Due to persistent tachycardia and an episode of collapse whilst seated on day 12, he was admitted to hospital for further investigation. A diagnosis of myocarditis was confirmed as a result of elevated cardiac enzyme levels and an echocardiogram. Following withdrawal of clozapine, supportive management, and initiation of cardiac medication, the patient made a successful recovery. He will be followed up with the cardiology team to ensure that his heart function returns to normal. Given the incidence of clozapine-induced myocarditis, the associated mortality risk, and diagnostic difficulties, this case raises questions about whether a formal system for identifying myocarditis should be adopted. |
| format | Article |
| id | doaj-art-6f767dc96a764412b6bdece20b6e7408 |
| institution | Kabale University |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-6f767dc96a764412b6bdece20b6e74082025-02-03T01:24:24ZengWileyCase Reports in Psychiatry2090-682X2090-68382016-01-01201610.1155/2016/41590814159081Lessons Learned and Questions Raised by an Atypical Case of Clozapine-Induced MyocarditisCharles H. Earnshaw0Lucy Powell1Owen Haeney2Aintree University Hospitals NHS Foundation Trust, Liverpool L9 7AL, UKMersey Care NHS Foundation Trust, Prescot, Liverpool L34 1PJ, UKMersey Care NHS Foundation Trust, Prescot, Liverpool L34 1PJ, UKA Caucasian male in his early twenties suffering from treatment resistant schizophrenia was started on clozapine. After three days he developed tachycardia, a common side effect of clozapine induction. He had one temperature spike (38.9°C) on day ten after induction but remained clinically well. An ECG and blood tests were normal. Due to persistent tachycardia and an episode of collapse whilst seated on day 12, he was admitted to hospital for further investigation. A diagnosis of myocarditis was confirmed as a result of elevated cardiac enzyme levels and an echocardiogram. Following withdrawal of clozapine, supportive management, and initiation of cardiac medication, the patient made a successful recovery. He will be followed up with the cardiology team to ensure that his heart function returns to normal. Given the incidence of clozapine-induced myocarditis, the associated mortality risk, and diagnostic difficulties, this case raises questions about whether a formal system for identifying myocarditis should be adopted.http://dx.doi.org/10.1155/2016/4159081 |
| spellingShingle | Charles H. Earnshaw Lucy Powell Owen Haeney Lessons Learned and Questions Raised by an Atypical Case of Clozapine-Induced Myocarditis Case Reports in Psychiatry |
| title | Lessons Learned and Questions Raised by an Atypical Case of Clozapine-Induced Myocarditis |
| title_full | Lessons Learned and Questions Raised by an Atypical Case of Clozapine-Induced Myocarditis |
| title_fullStr | Lessons Learned and Questions Raised by an Atypical Case of Clozapine-Induced Myocarditis |
| title_full_unstemmed | Lessons Learned and Questions Raised by an Atypical Case of Clozapine-Induced Myocarditis |
| title_short | Lessons Learned and Questions Raised by an Atypical Case of Clozapine-Induced Myocarditis |
| title_sort | lessons learned and questions raised by an atypical case of clozapine induced myocarditis |
| url | http://dx.doi.org/10.1155/2016/4159081 |
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