Nocardia thailandica Brain Abscess in an Immunocompromised Patient
Objectives. Successful treatment for Nocardia thailandica is not well elucidated in the literature. To the best of our knowledge, N. thailandica has not yet been described in the medical literature to cause central nervous system (CNS) infection from brain abscess. We report the case of an immunocom...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2021/6620049 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546065692229632 |
|---|---|
| author | Muhammad Effendi Samad Tirmizi Dayna McManus Anita J. Huttner David R. Peaper Jeffrey E. Topal |
| author_facet | Muhammad Effendi Samad Tirmizi Dayna McManus Anita J. Huttner David R. Peaper Jeffrey E. Topal |
| author_sort | Muhammad Effendi |
| collection | DOAJ |
| description | Objectives. Successful treatment for Nocardia thailandica is not well elucidated in the literature. To the best of our knowledge, N. thailandica has not yet been described in the medical literature to cause central nervous system (CNS) infection from brain abscess. We report the case of an immunocompromised patient who underwent successful treatment to treat his brain abscess caused by N. thailandica. Methods. After failing medical therapy, the patient underwent a craniotomy, and tissue was sent for culture. Upon identification by 16S rDNA sequencing, the organism causing infection was identified to be N. thailandica. Results. Based on susceptibilities, the patient was treated with IV ceftriaxone 2 grams daily for five months. The patient demonstrated clinical and radiological improvement which persisted to 7 months after initiation of therapy. Conclusions. To the best of our knowledge, this is the first documented case of a brain abscess due to N. thailandica which was successfully treated. Due to the location of the infection, ceftriaxone was chosen because of optimal CNS penetration. Ceftriaxone monotherapy demonstrated clinical and radiographic treatment success resulting in the successful treatment of this infection. |
| format | Article |
| id | doaj-art-6f70e2c51b814f86b56bb249282f1872 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-6f70e2c51b814f86b56bb249282f18722025-02-03T07:23:59ZengWileyCase Reports in Infectious Diseases2090-66252090-66332021-01-01202110.1155/2021/66200496620049Nocardia thailandica Brain Abscess in an Immunocompromised PatientMuhammad Effendi0Samad Tirmizi1Dayna McManus2Anita J. Huttner3David R. Peaper4Jeffrey E. Topal5Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USADepartment of Pharmacy, Yale New Haven Hospital, New Haven, CT, USADepartment of Pharmacy, Yale New Haven Hospital, New Haven, CT, USADepartment of Pathology, Yale School of Medicine, New Haven, CT, USADepartment of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USADepartment of Pharmacy, Yale New Haven Hospital, New Haven, CT, USAObjectives. Successful treatment for Nocardia thailandica is not well elucidated in the literature. To the best of our knowledge, N. thailandica has not yet been described in the medical literature to cause central nervous system (CNS) infection from brain abscess. We report the case of an immunocompromised patient who underwent successful treatment to treat his brain abscess caused by N. thailandica. Methods. After failing medical therapy, the patient underwent a craniotomy, and tissue was sent for culture. Upon identification by 16S rDNA sequencing, the organism causing infection was identified to be N. thailandica. Results. Based on susceptibilities, the patient was treated with IV ceftriaxone 2 grams daily for five months. The patient demonstrated clinical and radiological improvement which persisted to 7 months after initiation of therapy. Conclusions. To the best of our knowledge, this is the first documented case of a brain abscess due to N. thailandica which was successfully treated. Due to the location of the infection, ceftriaxone was chosen because of optimal CNS penetration. Ceftriaxone monotherapy demonstrated clinical and radiographic treatment success resulting in the successful treatment of this infection.http://dx.doi.org/10.1155/2021/6620049 |
| spellingShingle | Muhammad Effendi Samad Tirmizi Dayna McManus Anita J. Huttner David R. Peaper Jeffrey E. Topal Nocardia thailandica Brain Abscess in an Immunocompromised Patient Case Reports in Infectious Diseases |
| title | Nocardia thailandica Brain Abscess in an Immunocompromised Patient |
| title_full | Nocardia thailandica Brain Abscess in an Immunocompromised Patient |
| title_fullStr | Nocardia thailandica Brain Abscess in an Immunocompromised Patient |
| title_full_unstemmed | Nocardia thailandica Brain Abscess in an Immunocompromised Patient |
| title_short | Nocardia thailandica Brain Abscess in an Immunocompromised Patient |
| title_sort | nocardia thailandica brain abscess in an immunocompromised patient |
| url | http://dx.doi.org/10.1155/2021/6620049 |
| work_keys_str_mv | AT muhammadeffendi nocardiathailandicabrainabscessinanimmunocompromisedpatient AT samadtirmizi nocardiathailandicabrainabscessinanimmunocompromisedpatient AT daynamcmanus nocardiathailandicabrainabscessinanimmunocompromisedpatient AT anitajhuttner nocardiathailandicabrainabscessinanimmunocompromisedpatient AT davidrpeaper nocardiathailandicabrainabscessinanimmunocompromisedpatient AT jeffreyetopal nocardiathailandicabrainabscessinanimmunocompromisedpatient |