Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients
Background. Toll-like receptors (TLRs) have been suggested to be associated with the development of AITD. Methods. Fifteen single-nucleotide polymorphisms in 7 TLR genes were analyzed in 104 Korean children (girls = 86, boys = 18) with AITD (Hashimoto disease (HD) = 44, Graves’ disease (GD) = 60, th...
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/2304218 |
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| author | Won Kyoung Cho Jung-Pil Jang Eun-Jeong Choi Moonbae Ahn Shin Hee Kim Kyoung Soon Cho So Hyun Park In Cheol Baek Min Ho Jung Tai-Gyu Kim Byung-Kyu Suh |
| author_facet | Won Kyoung Cho Jung-Pil Jang Eun-Jeong Choi Moonbae Ahn Shin Hee Kim Kyoung Soon Cho So Hyun Park In Cheol Baek Min Ho Jung Tai-Gyu Kim Byung-Kyu Suh |
| author_sort | Won Kyoung Cho |
| collection | DOAJ |
| description | Background. Toll-like receptors (TLRs) have been suggested to be associated with the development of AITD. Methods. Fifteen single-nucleotide polymorphisms in 7 TLR genes were analyzed in 104 Korean children (girls = 86, boys = 18) with AITD (Hashimoto disease (HD) = 44, Graves’ disease (GD) = 60, thyroid-associated ophthalmopathy (TAO) = 29, and non-TAO = 31) with 183 controls. Results. GD showed higher frequencies of the TLR4 rs1927911 C allele than control. TAO showed a lower frequency of the TLR4 rs1927911 CT genotype and non-TAO showed a higher frequency of the TLR4 rs1927911 CC genotype than control. The frequency of the TLR9 rs187084 CC genotype in TAO was higher than that in non-TAO. GD females showed a higher frequency of the TLR4 rs10759932 T allele, rs1927911 CC genotype, and the rs1927911 C allele than controls. GD males showed a higher frequency of the TLR4 rs10759932 CC genotype and rs1927911 TT genotype and lower frequency of the rs1927911 CT genotype than control. The frequency of the TLR4 rs10759932 CC genotype, C allele and rs1927911 TT genotype, and T allele in a GD female were lower than in a GD male. Conclusions. Our results suggest that TLR4 and 9 polymorphisms might contribute to the pathogenesis of GD and TAO. |
| format | Article |
| id | doaj-art-6f6e70911cfa456da0813cfb036787b4 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6f6e70911cfa456da0813cfb036787b42025-02-03T06:06:26ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/23042182304218Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric PatientsWon Kyoung Cho0Jung-Pil Jang1Eun-Jeong Choi2Moonbae Ahn3Shin Hee Kim4Kyoung Soon Cho5So Hyun Park6In Cheol Baek7Min Ho Jung8Tai-Gyu Kim9Byung-Kyu Suh10Department of Pediatrics, College of Medicine, St. Vincent’s Hospital, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaCatholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Pediatrics, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Pediatrics, College of Medicine, Incheon St. Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Pediatrics, College of Medicine, Bucheon St. Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Pediatrics, College of Medicine, St. Vincent’s Hospital, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Pediatrics, College of Medicine, Yeouido St. Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Pediatrics, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of KoreaBackground. Toll-like receptors (TLRs) have been suggested to be associated with the development of AITD. Methods. Fifteen single-nucleotide polymorphisms in 7 TLR genes were analyzed in 104 Korean children (girls = 86, boys = 18) with AITD (Hashimoto disease (HD) = 44, Graves’ disease (GD) = 60, thyroid-associated ophthalmopathy (TAO) = 29, and non-TAO = 31) with 183 controls. Results. GD showed higher frequencies of the TLR4 rs1927911 C allele than control. TAO showed a lower frequency of the TLR4 rs1927911 CT genotype and non-TAO showed a higher frequency of the TLR4 rs1927911 CC genotype than control. The frequency of the TLR9 rs187084 CC genotype in TAO was higher than that in non-TAO. GD females showed a higher frequency of the TLR4 rs10759932 T allele, rs1927911 CC genotype, and the rs1927911 C allele than controls. GD males showed a higher frequency of the TLR4 rs10759932 CC genotype and rs1927911 TT genotype and lower frequency of the rs1927911 CT genotype than control. The frequency of the TLR4 rs10759932 CC genotype, C allele and rs1927911 TT genotype, and T allele in a GD female were lower than in a GD male. Conclusions. Our results suggest that TLR4 and 9 polymorphisms might contribute to the pathogenesis of GD and TAO.http://dx.doi.org/10.1155/2017/2304218 |
| spellingShingle | Won Kyoung Cho Jung-Pil Jang Eun-Jeong Choi Moonbae Ahn Shin Hee Kim Kyoung Soon Cho So Hyun Park In Cheol Baek Min Ho Jung Tai-Gyu Kim Byung-Kyu Suh Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients International Journal of Endocrinology |
| title | Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients |
| title_full | Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients |
| title_fullStr | Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients |
| title_full_unstemmed | Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients |
| title_short | Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients |
| title_sort | association of polymorphisms in toll like receptors 4 and 9 with autoimmune thyroid disease in korean pediatric patients |
| url | http://dx.doi.org/10.1155/2017/2304218 |
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