The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population
Background. Psoriasis is a multifactorial immune-mediated inflammatory disease triggered by both genetic and environmental factors. The strong association between psoriasis and HLA-C⁎06 allele has been demonstrated in various races. The HLA-C⁎12 allele is closely related to the HLA-C⁎06 family of al...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2019/7848314 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558867548995584 |
|---|---|
| author | Nahide Onsun Serpil Pirmit Dilek Ozkaya Şirin Çelik Aylin Rezvani F. Pelin Cengiz Cigdem Kekik |
| author_facet | Nahide Onsun Serpil Pirmit Dilek Ozkaya Şirin Çelik Aylin Rezvani F. Pelin Cengiz Cigdem Kekik |
| author_sort | Nahide Onsun |
| collection | DOAJ |
| description | Background. Psoriasis is a multifactorial immune-mediated inflammatory disease triggered by both genetic and environmental factors. The strong association between psoriasis and HLA-C⁎06 allele has been demonstrated in various races. The HLA-C⁎12 allele is closely related to the HLA-C⁎06 family of alleles and shares identical sequences. To the best of our knowledge, there is no information about the relationship between HLA-C⁎12 and psoriasis in the Turkish population. The present study aims to determine this relationship. Methods. This case control study involved 150 patients with plaque-type psoriasis and 145 age- and gender-matched healthy individuals. Severity of psoriasis was measured using the PASI scores of all patients and joint involvement was investigated with CASPAR criteria. HLA-C alleles were determined with a Tepnel-Lifecodes system. Results. HLA-C⁎06, HLA-C⁎12, and HLA-C⁎04 alleles were most commonly observed in psoriasis patients. HLA-C⁎06 and HLA-C⁎12 were significantly more frequent in the psoriasis group. HLA-C⁎06 was 4.11 times more common in psoriasis patients. An increase in PASI (Psoriasis Area Severity Index) scores was compatible with HLA-C⁎12 positivity. A need for systemic treatment was highly noticeable in patients with the HLA-C⁎12 allele. Conclusions. HLA-C⁎12 was found as the second most frequent allele with psoriasis in Turkish population and was associated with severe psoriasis. Our study is limited as we could not investigate other potentially related alleles other than HLA-C alleles and risk factors increasing severity of psoriasis. |
| format | Article |
| id | doaj-art-6f680189709747ce898811a586bb7511 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-6f680189709747ce898811a586bb75112025-02-03T01:31:25ZengWileyThe Scientific World Journal2356-61401537-744X2019-01-01201910.1155/2019/78483147848314The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish PopulationNahide Onsun0Serpil Pirmit1Dilek Ozkaya2Şirin Çelik3Aylin Rezvani4F. Pelin Cengiz5Cigdem Kekik6Department of Dermatology, Bezmialem Vakif University Medical School, TurkeyIstanbul Lepra Hospital, Ministry of Health, TurkeyDepartment of Dermatology, Bezmialem Vakif University Medical School, TurkeyDepartment of Dermatology, Bezmialem Vakif University Medical School, TurkeyDeparment of Rheumatology, Bezmialem Vakif University Medical School, TurkeyDepartment of Dermatology, Bezmialem Vakif University Medical School, TurkeyIstanbul University Medical School Medical Biology Department, TurkeyBackground. Psoriasis is a multifactorial immune-mediated inflammatory disease triggered by both genetic and environmental factors. The strong association between psoriasis and HLA-C⁎06 allele has been demonstrated in various races. The HLA-C⁎12 allele is closely related to the HLA-C⁎06 family of alleles and shares identical sequences. To the best of our knowledge, there is no information about the relationship between HLA-C⁎12 and psoriasis in the Turkish population. The present study aims to determine this relationship. Methods. This case control study involved 150 patients with plaque-type psoriasis and 145 age- and gender-matched healthy individuals. Severity of psoriasis was measured using the PASI scores of all patients and joint involvement was investigated with CASPAR criteria. HLA-C alleles were determined with a Tepnel-Lifecodes system. Results. HLA-C⁎06, HLA-C⁎12, and HLA-C⁎04 alleles were most commonly observed in psoriasis patients. HLA-C⁎06 and HLA-C⁎12 were significantly more frequent in the psoriasis group. HLA-C⁎06 was 4.11 times more common in psoriasis patients. An increase in PASI (Psoriasis Area Severity Index) scores was compatible with HLA-C⁎12 positivity. A need for systemic treatment was highly noticeable in patients with the HLA-C⁎12 allele. Conclusions. HLA-C⁎12 was found as the second most frequent allele with psoriasis in Turkish population and was associated with severe psoriasis. Our study is limited as we could not investigate other potentially related alleles other than HLA-C alleles and risk factors increasing severity of psoriasis.http://dx.doi.org/10.1155/2019/7848314 |
| spellingShingle | Nahide Onsun Serpil Pirmit Dilek Ozkaya Şirin Çelik Aylin Rezvani F. Pelin Cengiz Cigdem Kekik The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population The Scientific World Journal |
| title | The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population |
| title_full | The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population |
| title_fullStr | The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population |
| title_full_unstemmed | The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population |
| title_short | The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population |
| title_sort | hla cw12 allele is an important susceptibility allele for psoriasis and is associated with resistant psoriasis in the turkish population |
| url | http://dx.doi.org/10.1155/2019/7848314 |
| work_keys_str_mv | AT nahideonsun thehlacw12alleleisanimportantsusceptibilityalleleforpsoriasisandisassociatedwithresistantpsoriasisintheturkishpopulation AT serpilpirmit thehlacw12alleleisanimportantsusceptibilityalleleforpsoriasisandisassociatedwithresistantpsoriasisintheturkishpopulation AT dilekozkaya thehlacw12alleleisanimportantsusceptibilityalleleforpsoriasisandisassociatedwithresistantpsoriasisintheturkishpopulation AT sirincelik thehlacw12alleleisanimportantsusceptibilityalleleforpsoriasisandisassociatedwithresistantpsoriasisintheturkishpopulation AT aylinrezvani thehlacw12alleleisanimportantsusceptibilityalleleforpsoriasisandisassociatedwithresistantpsoriasisintheturkishpopulation AT fpelincengiz thehlacw12alleleisanimportantsusceptibilityalleleforpsoriasisandisassociatedwithresistantpsoriasisintheturkishpopulation AT cigdemkekik thehlacw12alleleisanimportantsusceptibilityalleleforpsoriasisandisassociatedwithresistantpsoriasisintheturkishpopulation AT nahideonsun hlacw12alleleisanimportantsusceptibilityalleleforpsoriasisandisassociatedwithresistantpsoriasisintheturkishpopulation AT serpilpirmit hlacw12alleleisanimportantsusceptibilityalleleforpsoriasisandisassociatedwithresistantpsoriasisintheturkishpopulation AT dilekozkaya hlacw12alleleisanimportantsusceptibilityalleleforpsoriasisandisassociatedwithresistantpsoriasisintheturkishpopulation AT sirincelik hlacw12alleleisanimportantsusceptibilityalleleforpsoriasisandisassociatedwithresistantpsoriasisintheturkishpopulation AT aylinrezvani hlacw12alleleisanimportantsusceptibilityalleleforpsoriasisandisassociatedwithresistantpsoriasisintheturkishpopulation AT fpelincengiz hlacw12alleleisanimportantsusceptibilityalleleforpsoriasisandisassociatedwithresistantpsoriasisintheturkishpopulation AT cigdemkekik hlacw12alleleisanimportantsusceptibilityalleleforpsoriasisandisassociatedwithresistantpsoriasisintheturkishpopulation |