Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms
Background. Limited research is available regarding colorectal NENs and the prognostic factors remain controversial. Materials and Methods. A total of 68 patients with colorectal NENs were studied retrospectively. Clinical characteristics and prognosis between colonic and rectal NENs were compared....
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/4206172 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850222377968861184 |
|---|---|
| author | Mengjie Jiang Yinuo Tan Xiaofen Li Jianfei Fu Hanguang Hu Xianyun Ye Ying Cao Jinghong Xu Ying Yuan |
| author_facet | Mengjie Jiang Yinuo Tan Xiaofen Li Jianfei Fu Hanguang Hu Xianyun Ye Ying Cao Jinghong Xu Ying Yuan |
| author_sort | Mengjie Jiang |
| collection | DOAJ |
| description | Background. Limited research is available regarding colorectal NENs and the prognostic factors remain controversial. Materials and Methods. A total of 68 patients with colorectal NENs were studied retrospectively. Clinical characteristics and prognosis between colonic and rectal NENs were compared. The Cox regression models were used to evaluate the predictive capacity. Results. Of the 68 colorectal NENs patients, 43 (63.2%) had rectal NENs, and 25 (36.8%) had colonic NENs. Compared with rectal NENs, colonic NENs more frequently exhibited larger tumor size (P<0.0001) and distant metastasis (P<0.0001). Colonic NENs had a worse prognosis (P=0.027), with 5-year overall survival rates of 66.7% versus 88.1%. NET, NEC, and MANEC were noted in 61.8%, 23.5%, and 14.7% of patients, respectively. Multivariate analyses revealed that tumor location was not an independent prognostic factor (P=0.081), but tumor size (P=0.037) and pathological classification (P=0.012) were independent prognostic factors. Conclusion. Significant differences exist between colonic and rectal NENs. Multivariate analysis indicated that tumor size and pathological classification were associated with prognosis. Tumor location was not an independent factor. The worse outcome of colonic NENs observed in clinical practice might be due not only to the biological differences, but also to larger tumor size in colonic NENs caused by the delayed diagnosis. |
| format | Article |
| id | doaj-art-6f61a734e86542cd99a979baadf4c269 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-6f61a734e86542cd99a979baadf4c2692025-08-20T02:06:22ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/42061724206172Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine NeoplasmsMengjie Jiang0Yinuo Tan1Xiaofen Li2Jianfei Fu3Hanguang Hu4Xianyun Ye5Ying Cao6Jinghong Xu7Ying Yuan8Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaDepartment of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaDepartment of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaCancer Institute (Key Laboratory of Cancer Prevention and Intervention, Chinese National Ministry of Education; Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaDepartment of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaDepartment of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaDepartment of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaDepartment of Pathology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaDepartment of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaBackground. Limited research is available regarding colorectal NENs and the prognostic factors remain controversial. Materials and Methods. A total of 68 patients with colorectal NENs were studied retrospectively. Clinical characteristics and prognosis between colonic and rectal NENs were compared. The Cox regression models were used to evaluate the predictive capacity. Results. Of the 68 colorectal NENs patients, 43 (63.2%) had rectal NENs, and 25 (36.8%) had colonic NENs. Compared with rectal NENs, colonic NENs more frequently exhibited larger tumor size (P<0.0001) and distant metastasis (P<0.0001). Colonic NENs had a worse prognosis (P=0.027), with 5-year overall survival rates of 66.7% versus 88.1%. NET, NEC, and MANEC were noted in 61.8%, 23.5%, and 14.7% of patients, respectively. Multivariate analyses revealed that tumor location was not an independent prognostic factor (P=0.081), but tumor size (P=0.037) and pathological classification (P=0.012) were independent prognostic factors. Conclusion. Significant differences exist between colonic and rectal NENs. Multivariate analysis indicated that tumor size and pathological classification were associated with prognosis. Tumor location was not an independent factor. The worse outcome of colonic NENs observed in clinical practice might be due not only to the biological differences, but also to larger tumor size in colonic NENs caused by the delayed diagnosis.http://dx.doi.org/10.1155/2017/4206172 |
| spellingShingle | Mengjie Jiang Yinuo Tan Xiaofen Li Jianfei Fu Hanguang Hu Xianyun Ye Ying Cao Jinghong Xu Ying Yuan Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms Gastroenterology Research and Practice |
| title | Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms |
| title_full | Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms |
| title_fullStr | Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms |
| title_full_unstemmed | Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms |
| title_short | Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms |
| title_sort | clinicopathological features and prognostic factors of colorectal neuroendocrine neoplasms |
| url | http://dx.doi.org/10.1155/2017/4206172 |
| work_keys_str_mv | AT mengjiejiang clinicopathologicalfeaturesandprognosticfactorsofcolorectalneuroendocrineneoplasms AT yinuotan clinicopathologicalfeaturesandprognosticfactorsofcolorectalneuroendocrineneoplasms AT xiaofenli clinicopathologicalfeaturesandprognosticfactorsofcolorectalneuroendocrineneoplasms AT jianfeifu clinicopathologicalfeaturesandprognosticfactorsofcolorectalneuroendocrineneoplasms AT hanguanghu clinicopathologicalfeaturesandprognosticfactorsofcolorectalneuroendocrineneoplasms AT xianyunye clinicopathologicalfeaturesandprognosticfactorsofcolorectalneuroendocrineneoplasms AT yingcao clinicopathologicalfeaturesandprognosticfactorsofcolorectalneuroendocrineneoplasms AT jinghongxu clinicopathologicalfeaturesandprognosticfactorsofcolorectalneuroendocrineneoplasms AT yingyuan clinicopathologicalfeaturesandprognosticfactorsofcolorectalneuroendocrineneoplasms |